Difference between revisions of "Team:UST Beijing/Background"
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<li><a href="https://2018.igem.org/Team:UST_Beijing/Attributions">Attribution</a ></li> | <li><a href="https://2018.igem.org/Team:UST_Beijing/Attributions">Attribution</a ></li> | ||
<li><a href="https://2018.igem.org/Team:UST_Beijing/Collaborations">Collaboration</a ></li> | <li><a href="https://2018.igem.org/Team:UST_Beijing/Collaborations">Collaboration</a ></li> | ||
| − | <li><a href="https:// | + | <li><a href="https://static.igem.org/mediawiki/2018/5/5a/T--UST_Beijing--Demonstrate.pdf">Demonstrate</a ></li> |
<li><a href="https://2018.igem.org/Team:UST_Beijing/InterLab">InterLab</a ></li> | <li><a href="https://2018.igem.org/Team:UST_Beijing/InterLab">InterLab</a ></li> | ||
<li><a href="https://2018.igem.org/Team:UST_Beijing/Human_Practices">HumanPractice</a ></li> | <li><a href="https://2018.igem.org/Team:UST_Beijing/Human_Practices">HumanPractice</a ></li> | ||
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<blockquote> | <blockquote> | ||
| − | < | + | <h2><span>Cholesterol</span></h2> |
| − | < | + | <h3>an essential component of membrane structure, but gradually |
| − | accumulates in arteries of human body, which becomes the top one killer mechanism of human life: | + | accumulates in arteries of human body, which becomes the top one killer mechanism of human life: <span>atherosclerosis</span></h3> |
| − | + | <h2><span> An alarming health threat: Atherosclerosis</span></h2> | |
| − | < | + | <h3>Shown on the right are the cholesterol structure and pie charts of epidemic statistics of atherosclerosis-related mortality in China (black area: atherosclerosis-related death).</h3> |
| − | < | + | |
</blockquote> | </blockquote> | ||
</div> | </div> | ||
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<div class="pad15"></div> | <div class="pad15"></div> | ||
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<h2><span>Pathology of Atheroscleosis</span></h2> | <h2><span>Pathology of Atheroscleosis</span></h2> | ||
| − | < | + | <h3>Cholesterol is the main culprit of cardio-and cerebro-vascular disease. Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. In heart it causes heart attack. In brain it causes blockage stroke.</h3> |
<div class="pad15"></div> | <div class="pad15"></div> | ||
<div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/b/b0/T--UST_Beijing--bg10.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/7/75/T--UST_Beijing--bg5.jpg" alt="" /></a> </div> | <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/b/b0/T--UST_Beijing--bg10.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/7/75/T--UST_Beijing--bg5.jpg" alt="" /></a> </div> | ||
<div class="pad45"></div> | <div class="pad45"></div> | ||
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<h2><span>Molecular Mechanism of Atherosclerosis Formation</span></h2> | <h2><span>Molecular Mechanism of Atherosclerosis Formation</span></h2> | ||
| − | < | + | <h3>Because of foam cell apoptosis, which is formed by macrophages overloading cholesterol, cholesterol is deposited on the inner wall of artery.</h3> |
<div class="pad15"></div> | <div class="pad15"></div> | ||
<div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/e/ed/T--UST_Beijing--bg8.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/5/5b/T--UST_Beijing--bg6.jpg" alt="" /></a> </div> | <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/e/ed/T--UST_Beijing--bg8.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/5/5b/T--UST_Beijing--bg6.jpg" alt="" /></a> </div> | ||
<div class="pad45"></div> | <div class="pad45"></div> | ||
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<h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2> | <h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2> | ||
| − | < | + | <h3>Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.</h3> |
<div class="pad15"></div> | <div class="pad15"></div> | ||
<div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div> | <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div> | ||
| + | </div> | ||
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| + | <div class="span6 pad10"> | ||
| + | <h2><span> Actions of LXR </span></h2> | ||
| + | <h3>LXRs have a typical nuclear receptor structure. Upon bound by agonists (such as ginseno-sterols), LXRs would recruit co-activators (shown in the animation, only a fragment of coactivator peptide is displayed)and activate the transcription of a target gene.</h3> | ||
| + | <div class="vendor"> | ||
| + | <iframe src="https://static.igem.org/mediawiki/2018/b/bc/T--UST_Beijing--bgbg.mp4" height="500"></iframe> | ||
| + | </div> | ||
</div> | </div> | ||
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<div class="pad15"></div> | <div class="pad15"></div> | ||
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| − | < | + | <h3>Ginseng triterpenes' structure is similar to that of cholesterol, therefore it has the potential of regulating LXRs. |
| − | LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to specific site on a target gene promoter region to activate transcription of the target gene. Ginsenosides or like could therefore regulate the metabolism of cholesterol. </ | + | LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to specific site on a target gene promoter region to activate transcription of the target gene. Ginsenosides or like could therefore regulate the metabolism of cholesterol. </h3> |
</div> | </div> | ||
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<div class="span6 element category01" data-category="category01"> | <div class="span6 element category01" data-category="category01"> | ||
<div class="hover_img"> <a href="https://static.igem.org/mediawiki/2018/1/17/T--UST_Beijing--bgpic11.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/1/17/T--UST_Beijing--bgpic11.jpg" alt="" /></a> </div> | <div class="hover_img"> <a href="https://static.igem.org/mediawiki/2018/1/17/T--UST_Beijing--bgpic11.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/1/17/T--UST_Beijing--bgpic11.jpg" alt="" /></a> </div> | ||
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<div class="hover_img"> <a href="https://static.igem.org/mediawiki/2018/2/26/T--UST_Beijing--bgpic12.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/2/26/T--UST_Beijing--bgpic12.jpg" alt="" /></a> </div> | <div class="hover_img"> <a href="https://static.igem.org/mediawiki/2018/2/26/T--UST_Beijing--bgpic12.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/2/26/T--UST_Beijing--bgpic12.jpg" alt="" /></a> </div> | ||
<div class="item_description"><h1><span>Atherosclerosis formation is delayed<br>by ginsenosides in vivo</span></h1></div> | <div class="item_description"><h1><span>Atherosclerosis formation is delayed<br>by ginsenosides in vivo</span></h1></div> | ||
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Latest revision as of 15:28, 16 October 2018
Cholesterol
an essential component of membrane structure, but gradually accumulates in arteries of human body, which becomes the top one killer mechanism of human life: atherosclerosis
An alarming health threat: Atherosclerosis
Shown on the right are the cholesterol structure and pie charts of epidemic statistics of atherosclerosis-related mortality in China (black area: atherosclerosis-related death).
Pathology of Atheroscleosis
Cholesterol is the main culprit of cardio-and cerebro-vascular disease. Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. In heart it causes heart attack. In brain it causes blockage stroke.
Molecular Mechanism of Atherosclerosis Formation
Because of foam cell apoptosis, which is formed by macrophages overloading cholesterol, cholesterol is deposited on the inner wall of artery.
Nuclear receptor LXR as therapeutic target against atherosclerosis
Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.
Actions of LXR
LXRs have a typical nuclear receptor structure. Upon bound by agonists (such as ginseno-sterols), LXRs would recruit co-activators (shown in the animation, only a fragment of coactivator peptide is displayed)and activate the transcription of a target gene.
Ginseng triterpenes' structure is similar to that of cholesterol, therefore it has the potential of regulating LXRs. LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to specific site on a target gene promoter region to activate transcription of the target gene. Ginsenosides or like could therefore regulate the metabolism of cholesterol.
Ginsenoside TR1 modulates
LXR biological activity
