Difference between revisions of "Team:Toulouse-INSA-UPS/Entrepreneurship"

 
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<h1 id="ANCHOR_0" class="heavy">ENTREPRENEURSHIP</h1>
 
<h1 id="ANCHOR_0" class="heavy">ENTREPRENEURSHIP</h1>
 
<hr/>
 
<hr/>
        <h2 class="heavy">OVERVIEW</h2>
+
        <h2 class="heavy">OVERVIEW</h2><hr/>
  
  
                                   <p>We truly believed the usefulness of our Cerberus project, especially its business potentials. Indeed,the main goal of this iGEM project is to create endless possibilities with cellulose, which is the major organic component you can find on earth and is used in many industries, in various fields. So, it was essential for us to build an entrepreneurship approach in order to make our Cerberus alive, and permitting to fill the gap between lab work and industry issues (=les enjeux industriel).</p>
+
                                   <p>We truly believe in the business potentials of our Cerberus project. Cellulose is the major organic
 +
component found on Earth and it is used as a raw material in many industries. Functionalizing cellulose
 +
opens a wide range of new industrial perspectives with this material. The main goal of our iGEM
 +
project, Cerberus, is to create a versatile cellulose-binding platform allowing endless cellulose-
 +
functionalizing possibilities. We built an entrepreneurship approach based on our Cerberus project in
 +
order to fill the gap between lab work and industrial concerns.</p>
  
<p>Cerberus’ mission is to expand the cellulose properties, by providing an engineered protein to industrials who wants to functionalize cellulose. First, we achieved three functionalization which are antibiotic properties, fluorescence properties and paramagnetic properties, therefore we targeted health industry to imagine functionalized bandages; textile factory and conductive paper industry. But because we want to create endless possibilities for cellulose, as a startup, Cerberus would develop a strong R&amp;D department, to provide its advices and its skills to create new functionalization for cellulose, in collaboration with clients to meet the needs.</p>
 
 
<p>
 
<p>
To begin the entrepreneurship approach, we first met a startup biotech named pili.bio, their chief science officer provided us some advices to begin this entrepreneurship strategy and shared his experience as a co-founder of a startup. [linke avis d’expert hp]. Secondly, as we are producing our Cerberus protein as a prototype in the lab, we questioned ourselves about the scaling up of the production design, so we have a met the director of a biotech scale up named CRITT-Bio-industry to understand and try to solve this problem [link hp avis d’expert ].</p>
+
Our concept is to expand cellulose properties by providing an engineered
 +
Cerberus protein to functionalize cellulose according to industrus' needs. As a proof of concept of the
 +
relevance of our project, we succeeded in functionalizing cellulose with different properties: we
 +
conferred antibiotic, fluorescent and magnetic properties to cellulose. These experiments allowed
 +
us to consider targeting the health industry to conceive functionalized bandages, textile factories to
 +
develop clothe with new features and the conductive paper industry. Because we do not want to stop
 +
with these functions but ultimately create endless possibilities for cellulose, our Cerberus start-up
 +
will develop a strong R&amp;D department, to provide advice and skills creating new cellulose
 +
functionalization in collaboration with the clients to meet their needs.
 +
 
 +
</p>
 
<p>
 
<p>
Then, we collaborated with a business incubator named Le catalyseur, to build deeply the entrepreneurship part, working on the market strategy, the business model and the business plan. We were assisted by Nicolas Delcey the incubator coordinator and Eric Marchandier the director.</p>
+
To kickstart the entrepreneurship approach, we first met a startup biotech named pili.bio Their scientific
 +
director provided us with some advice to begin this strategy and shared his
 +
experience as a co-founder of a startup. Subsequently, since we are
 +
producing our Cerberus protein as a prototype in the lab, we wondered how to scale up the
 +
production process. To identify the challenges, we met the director of a biotechnology company
 +
specialized in scale-up of bioprocesses, CRITT-Bio-industry to understand this
 +
problem. For more information see our <a href="https://2018.igem.org/Team:Toulouse-INSA-UPS/Human_Practices">Human Practices Page</a>.
  
 +
<p>
 +
Finally, we collaborated with a business incubator named “Le Catalyseur” to go deeply into the
 +
entrepreneurship project, working on the market strategy, the business model and the business plan.
 +
We were assisted in this task by Nicolas Delcey, the incubator coordinator and Eric Marchandier the
 +
director.
 +
</p>
  
 
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<li class="nav-item">
 
<li class="nav-item">
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0 active" data-toggle="pill" href="#ENTREP_Part1" role="tab">Start-Up incubator</a>
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<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0 active" data-toggle="pill" href="#ENTREP_Part1" role="tab" style="color:white !important;">Start-Up incubator</a>
 
</li>
 
</li>
 
<li class="nav-item">
 
<li class="nav-item">
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part2" role="tab">Business Model Canvas</a>
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<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part2" role="tab" style="color:white !important;">Business Model Canvas</a>
 
</li>
 
</li>
 
<li class="nav-item">
 
<li class="nav-item">
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part3" role="tab">Market Analysis</a>
+
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part3" role="tab" style="color:white !important;">SWOT analysis</a>
 
</li>
 
</li>
 
<li class="nav-item">
 
<li class="nav-item">
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part4" role="tab">Business Plan</a>
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<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part4" role="tab" style="color:white !important;">Business Plan</a>
 
</li>
 
</li>
 
<li class="nav-item">
 
<li class="nav-item">
<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part5" role="tab">Perspectives</a>
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<a class="nav-link btn btn-secondary rounded-lg-top corner-lg-bottom mr-1 mb-1 mb-lg-0" data-toggle="pill" href="#ENTREP_Part5" role="tab" style="color:white !important;">Perspectives</a>
 
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<p>For every startup project, an incubator is the best place to encourage the growth and the achievement until a business. We had the opportunity to work with Le catalyseur which is a pre-incubator supporting undergraduate students which helps entrepreneurship project by providing them resources, networking and advices. We received resources, and personal training where we brainstormed our business vision of Cerberus, drived by entrepreneurship specialists. Working with Le catalyseur helped us to develop the right business application as seen on the business plan.</p>
+
<p>For any startup project, an incubator is the best place to support and encourage the
 +
growth and achievements from the early stages to the real business. We had the
 +
opportunity to work with “Le Catalyseur”, a pre-incubator supporting undergraduate
 +
students which helps entrepreneurship project by providing resources, networking
 +
and advice. We benefited from resources and personal training to brainstorm our
 +
business vision of Cerberus, chaperoned by entrepreneurship specialists. Working
 +
with “Le Catalyseur” helped us to develop the right business application as seen on
 +
the business plan.</p>
 
 
 
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<div style="text-align:center">
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<h3 class="heavy">Cerberus' Mission</h3>
 
<h3 class="heavy">Cerberus' Mission</h3>
 
<hr/>
 
<hr/>
<p>The firsts workshops consists to take a stock on Cerberus’ progress, analyzing different activity domains and agreed on the aim of the future company, using brand paper. After a few thoughts, we agreed that the startup’s mission would be to assist businesses to develop innovative materials by biosynthetic tools. Indeed, because we propose a wide range of functionalization we want to target a large market and constantly offer innovation. Therefore, we choose to become a consulting company specialized in cellulose functionalization.</p>
+
<p>The first workshops consisted of taking stock of our Cerberus project's progress, analyzing different
 +
domains of activity and defining the aim of the future company, using brand paper method. After thinking
 +
deeply, we all agreed that the mission of Cerberus would be to assist businesses to develop
 +
innovative materials using biosynthetic tools. Indeed, because we propose a wide range of
 +
functionalization we wish to target a large market and constantly offer innovations. Therefore, we
 +
chose to become a consulting company specialized in cellulose functionalization.</p>
 
 
 
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<div style="text-align:center">
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<h3 class="heavy">Risk Analysis</h3>
 
<h3 class="heavy">Risk Analysis</h3>
 
<hr/>
 
<hr/>
<p>The next workshop consists to build a risk analysis approach permitting the detection and the analysis of threats and vulnerabilities which can affect the Cerberus’ assets. The aim of this management approach is to find adequate countermeasures, depending on the impact we evaluated. In the previous workshop, we identified various activity domains, and we listed all the tasks corresponding. For the risk analysis we assessed each task and providing a grade regarding risk exposure and probability the risk happens. The table below corresponds to a summary of this workshop.</p>
+
<p>
 +
The next workshop consisted of conducting a risk analysis allowing detection and analysis of threats
 +
and vulnerabilities which could affect Cerberus’ assets. The aim of this management approach
 +
was to find relevant countermeasures, depending on the impact we evaluated. In the previous
 +
workshop, we identified various domains of activity and we listed all the corresponding tasks. For the
 +
risk analysis we assessed each task, attributed them a grade reflecting risk exposure and the
 +
probability that the risk would happen. The table below corresponds to a summary of this workshop.
 +
</p>
 
 
 
<div style="text-align:center">
 
<div style="text-align:center">
 
<figure class="figure" align= middle>
 
<figure class="figure" align= middle>
<img style="width : 70%; heigth = auto;" src="https://static.igem.org/mediawiki/2018/1/13/T--Toulouse-INSA-UPS--Entreup--Youn--Risktab.jpg" class="figure-img img-fluid rounded" alt="A generic square placeholder image with rounded corners in a figure.">
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<img style="width : 90%; heigth = auto;" src="https://static.igem.org/mediawiki/2018/1/13/T--Toulouse-INSA-UPS--Entreup--Youn--Risktab.jpg" class="figure-img img-fluid rounded" alt="A generic square placeholder image with rounded corners in a figure.">
 
<figcaption class="figure-caption"><strong>Figure 4:</strong> <i>Risk analysis table</i></figcaption>
 
<figcaption class="figure-caption"><strong>Figure 4:</strong> <i>Risk analysis table</i></figcaption>
 
</figure>
 
</figure>
 
</div>
 
</div>
 
 
<p>In the iGEM team we did not have business profile or commercial student, this is why the commercial domain is at its higher severity level, therefore it would be necessary to hire a commercial in order to start the business. </p>
+
<p>The commercial domain shows the highest severity level because nobody in our iGEM team has a
<p>Also, before putting Cerberus out the market we need to further the research and development aspect, even if we had great results and we demonstrated our work. </p>
+
business or commercial profile. Therefore, it will be crucial to hire a sales representative in order to
 +
start the business.</p>
 +
<p>
 +
In addition, before launching Cerberus on the market we need to improve the research and
 +
development aspect, even though we had great preliminary results and we provided proofs of
 +
concept of our project validity.
 +
</p>
 
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<hr/>
 
<hr/>
 
 
<p> The business model canvas is a tool permitting to identify all the key points essentials to start a business. This method is very useful, by presenting all the components of the company, the business model canvas asserts itself as a strategic tool. The structure of the document makes it easy to check the coherence of the project on the one hand and to highlight its added value on the other hand.</p>
+
<p> The business model canvas is a tool allowing us to identify all the essential aspects of starting a business.
 +
This method is very useful and by presenting all the components of the company, the business model
 +
canvas works as a strategic tool. The structure of the document makes it easy to check the
 +
coherence of the project and to highlight its added value.</p>
  
 
<div style="text-align:center">
 
<div style="text-align:center">
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</div>
 
</div>
  
                                 <p>The central bloc concerns the value proposition, which means the selling proposition proposed by the start up. In our case the Cerberus solution is an innovative method to functionalize cellulose thanks to a protein. We would provide advices and accompaniment in the design of linker, and the functionalized function for cellulose fiber. </p>
+
                                 <p>
                                 <p>Four blocs concern external aspects, they are mainly linked to the market environment. </p>
+
The central bloc presents the value proposition, which means the selling propositions of the startup.
                                 <p>1 . <strong>Customer segments:</strong> Corresponds to the various market groups which would be interested by our Cerberus solution. It could be plant cellulose producer, which would want to add properties to their fiber. Because cellulose is present in various textile type such as fashion or bandages we could target the textile industry and health industry. One of our proof of concept is to add magnetic properties to cellulose, we also imagined adding graphen or CNT for the conductivity properties. Therefore, we would target the electronic component industry.</p>
+
In our case the Cerberus solution is an innovative method to functionalize cellulose using a cellulose-
                                 <p>2 . <strong>Customer relationship:</strong> Because we would provide advices and conception design we would be a business to business society. There would have two types of contract:
+
binding protein. We would provide advice and support in the design of linkers and on the cellulose
                                    <ul><li> R&D contract: Providing the design of a linker in terms of the client needs. </li>
+
fiber functionalizing function.
 +
</p>
 +
                                 <p>  
 +
The four following blocs deal with external aspects, they are mainly linked to the market
 +
environment.
 +
 +
</p>
 +
                                 <p>1 . <strong>Customer segments:</strong> Corresponds to the various market groups that would be interested in our
 +
Cerberus solution. They could be plant cellulose producers who want to add properties to their
 +
fibers. Because cellulose is present in various textile types such as clothing or bandages, we could
 +
target both the textile industry and the health industry. One of our proof of concept is to confer
 +
magnetic properties to cellulose. We also considered adding graphen or carbon nanotubes (CNT) to
 +
confer conductivity properties to cellulose. Therefore, we could also target the electronic component
 +
industry.</p>
 +
                                 <p>2 . <strong>Customer relationship:</strong> Because we would provide advice and conception design, our start-up
 +
would be a business to business company. We would establish three types of contract:
 +
 
 +
<ul>
 +
<li>Support and advice contracts: We will offer our advice and accompaniment to the clients, and we
 +
will charge it per day.</li>
 +
<li> R&D contract: Providing the design of a linker in terms of the client needs. </li>
 
                                     <li>Production contract: Providing the linker produced by a partner.</li></ul>
 
                                     <li>Production contract: Providing the linker produced by a partner.</li></ul>
                                    </p>
+
 
                                 <p>3. <strong>Channels:</strong> This is corresponding to the wide channels permitting to make discover the business, deliver the value proposition, provide after-sales service. In our case it would be web sites, scientific publication, prospection, specialized forum or startup forum, and finally our professional network. </p>
+
</p>
                                <p>4. <strong>Revenue stream:</strong> Corresponds to the type of revenue generated from each customer segment. It would be product sales, patent sales, or right of exploitation. But it we could also collect money from bank loan of public investment</p>
+
                                 <p>3. <strong>Channels:</strong> This corresponds to the wide channels allowing the business to be discovered, deliver
 +
the value proposition, provide after-sales service. In our case it would be web sites, scientific
 +
publications, prospection, specialized forum or startup forum, and finally our professional network.</p>
 +
 
 +
<p>4. <strong>Revenue stream:</strong> Corresponds to the type of revenue generated from each customer segment. It would be product sales, patent sales, or right of exploitation. But it we could also collect money from bank loan of public investment.</p>
 
                                 <p>Four blocs concern internal aspects.</p>
 
                                 <p>Four blocs concern internal aspects.</p>
                                 <p>5. <strong>Key partners:</strong> Corresponds to the network of partners and key suppliers through which the business model works. On the one hand, we would need sub-contractor to scale up the production of the linker before providing it to industrials. Also, we would need a research laboratory and start up incubator such as TWB, permitting to continue the R&D research and improvement of the product, as well as raw materials producer. On another hand, we would need partners such as accounting firm, financial, business lawyer to protect our idea and health agency, to prevent all the possible risks.</p>
+
                                 <p>5. <strong>Key partners:</strong> Corresponds to the network of partners and key suppliers the business model relies
                                <p>6. <strong>Key activity:</strong> Corresponds to the most important things an organization needs to do to make its business model work. We identified two main sciences activity: R&D and production. But to run a business we would also need various activities such as Human resources, marketing, legal or financial activities. </p>
+
on. On the one hand, we need sub-contractors to scale up production of the linker before selling it to
                                 <p>7. <strong>Key resources:</strong> The most important assets required to run the organization’s business model. We identified four main aspects that corresponds to the four main profile of the co-founder of Cerberus business. But, the four co-founders have all done sciences studies, so a marketing profile is missing and to begin a business it is very important to have a multidisciplinary group.</p>
+
industrials. We would also need a research laboratory and a start-up incubator such as Toulouse
                                 <p>8. <strong>Cost structure:</strong> Which means all the different types of costs inherent in the economic model. We identified various types such as raw materials (enzyme, plasmids, antibiotics, buffer, products for the medium…), the equipment (Kit, PCR, electrophoresis ) but also salary and charges, certification audit and taxes. The distribution costs to provide to the client, the travel expenses to meet new customers by the commercial. </p>
+
White Biotechnology, allowing to continue R&amp;D to improve the products and produce raw materials.
 +
On the other hand, we need partners such as an accounting firm, investors a business lawyer firm to
 +
protect our ideas and a health agency to prevent all possible risks.</p>
 +
 
 +
<p>6. <strong>Key activity:</strong> Corresponds to the most important things an organization needs to do to make its
 +
business model work. We identified two mains scientific activities: R&amp;D and production. However, to
 +
run a business, we also need various activities such as Human resources, marketing, legal or financial
 +
activities. </p>
 +
                                 <p>7. <strong>Key resources:</strong> The most important assets required to run the organization’s business model. We
 +
identified four main aspects that correspond to the four main profiles of the co-founders of Cerberus
 +
business. However, the four co-founders have all done scientific studies, so marketing expertise will
 +
be missing. To begin the business, we will then either hire someone with a commercial profile or we
 +
will collaborate to have another co-founder.</p>
 +
                                 <p>8. <strong>Cost structure:</strong> This corresponds to the different costs inherent in the economic model. We
 +
identified various types such as basic reagent costs (molecular biology reagents, purification kits,
 +
culture media, ), equipment costs (PCR machines, electrophoresis apparatus, protein purification
 +
systems…) but also salaries and charges, certification audit and taxes. The distribution, the travel
 +
expenses to meet new customers by the sales representatives.</p>
 
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<h2 class="heavy">Market Analysis</h2>
+
<h2 class="heavy">SWOT Analysis</h2>
 
<hr/>
 
<hr/>
<p> The SWOT is a strategic analysis tool that generally applies to organizations. The SWOT puts into perspective the internal characteristics of the organization with the state of the environment in which it evolves. Concretely, this tool is simple and readable which presents: </p>
+
<p>  
                                <ul><li>The strengths and weaknesses of the company: <strong>INTERNAL analysis</strong> which therefore concerns elements on which we can act directly.</li>
+
The SWOT is a strategic tool allowing to put into perspective the internal characteristics of the business organization with the state of the environment in which it evolves. The SWOT makes it possible to anticipate strategic risks, to decide on a commercial positioning, or to refine an economic model.
                                    <li>The opportunities and threats of the environment: we are here at an <strong>EXTERNAL</strong> level to the company, to observe the elements on which it is not possible to act directly, and which will require an adaptation.</li></ul>
+
</p>
                                <p>The SWOT makes it possible to anticipate strategic risks, to decide on a commercial positioning, or to refine an economic model.</p>
+
 
 
                                 <figure class="figure" align= middle>
 
                                 <figure class="figure" align= middle>
 
                                     <img style="width : 100%; heigth = auto;" src="https://static.igem.org/mediawiki/2018/9/96/T--Toulouse-INSA-UPS--Entreup--SWOT.jpg" class="figure-img img-fluid rounded" alt="A generic square placeholder image with rounded corners in a figure.">
 
                                     <img style="width : 100%; heigth = auto;" src="https://static.igem.org/mediawiki/2018/9/96/T--Toulouse-INSA-UPS--Entreup--SWOT.jpg" class="figure-img img-fluid rounded" alt="A generic square placeholder image with rounded corners in a figure.">
 
                                     <figcaption class="figure-caption"><strong>Figure 1:</strong> <i>SWOT of our project </i></figcaption>
 
                                     <figcaption class="figure-caption"><strong>Figure 1:</strong> <i>SWOT of our project </i></figcaption>
 
                                 </figure>
 
                                 </figure>
+
<p>
 +
One of the main opportunity is the iGEM exposure in an international level. Indeed, we built a web site where we reported our entire project, from design to the demonstration of our work. Moreover, there is a real development of the financial contributions to help startup especially biotech research<sup>1</sup>. There is also a real demand for new fabrics, and textile market is constantly evolving to develop innovation<sup>2</sup>. The ecological aspect is more and more present and will be one of the major aspects that industries would have to consider. Also, one of the advantages of our project is the wide range of market and clients we would target. Therefore, the team has a strong formation in science and will have a large network from their university INSA, UPS and the After iGEM community.
 +
</p>
 +
<p>
 +
Otherwise, we are not graduated yet and we have a lack of experience. Because we are scientists, we need to hire a marketing profile in order to have a different vision and a business expertise. Moreover, the field of biotechnology requires major investments for R&D and the risk is rather high, therefore companies are generally important laboratories with global influence. After the iGEM competition, which is open source, we will have some problems to effectively protect our work. Also, people have strong suspicions about GMO’s.
 +
</p>
 +
<h3 class="heavy">References</h3>
 +
<ol>
 +
<i>
 +
<li>Moedas, C. La biotechnologie industrielle, facteur de développement durable et de croissance verte. Annales des Mines - Réalités industrielles Février 2017, 5–7 (2017).</li>
 +
<li>Croissance du marché des textiles techniques: quelques tendances chiffrées. Mode in Textile (2018).</li>
 +
</i>
 +
</ol>
 
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<h2 class="heavy">Perspectives</h2>
 
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<p>
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Our combined efforts have enabled us to gain enough confidence to start our entrepreneurship journey. We started from scratch and through the months spent working on our project, consulting experts and planning our future, we gained solid experience in the domain of Synthetic Biology applications to new materials.  
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</p>
 +
<p>
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As our design has been validated by several proofs of concept, we can now think of all the possibilities that can emerge. We will first be a consulting company providing design and support to businesses, creating endless functionalization for cellulose based materials. We have established three types of service; support and advice contracts; R&D contracts and production contracts. Because we need more time to optimize the production of the protein depending on the client’s needs, we will fully develop this service in the near future.
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As bacterial cellulose is a very promising material, we are probably at the beginning of the next trend in fashion or next generation textiles. So, as a long-term goal for the company, we can imagine a bacterial cellulose production to create clothes functionalized by our protein. Who knows, maybe this will become the next big thing?.
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</p>
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<p>
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The frightened students that entered the iGEM Toulouse Team have now evolved; into lab scientists, project managers, accountants and molecular modelers. Of course, we still need stronger skills to make our company a success, but we are all excited about the perspectives offered by our entrepreneurship approach.
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As iGEM has taught us, the key to success lies in hard work and determination  to achieve our dreams. We will never forget this lesson as it has built the scientists we are today.
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Latest revision as of 23:29, 17 October 2018

ENTREPRENEURSHIP


OVERVIEW


We truly believe in the business potentials of our Cerberus project. Cellulose is the major organic component found on Earth and it is used as a raw material in many industries. Functionalizing cellulose opens a wide range of new industrial perspectives with this material. The main goal of our iGEM project, Cerberus, is to create a versatile cellulose-binding platform allowing endless cellulose- functionalizing possibilities. We built an entrepreneurship approach based on our Cerberus project in order to fill the gap between lab work and industrial concerns.

Our concept is to expand cellulose properties by providing an engineered Cerberus protein to functionalize cellulose according to industrus' needs. As a proof of concept of the relevance of our project, we succeeded in functionalizing cellulose with different properties: we conferred antibiotic, fluorescent and magnetic properties to cellulose. These experiments allowed us to consider targeting the health industry to conceive functionalized bandages, textile factories to develop clothe with new features and the conductive paper industry. Because we do not want to stop with these functions but ultimately create endless possibilities for cellulose, our Cerberus start-up will develop a strong R&D department, to provide advice and skills creating new cellulose functionalization in collaboration with the clients to meet their needs.

To kickstart the entrepreneurship approach, we first met a startup biotech named pili.bio Their scientific director provided us with some advice to begin this strategy and shared his experience as a co-founder of a startup. Subsequently, since we are producing our Cerberus protein as a prototype in the lab, we wondered how to scale up the production process. To identify the challenges, we met the director of a biotechnology company specialized in scale-up of bioprocesses, CRITT-Bio-industry to understand this problem. For more information see our Human Practices Page.

Finally, we collaborated with a business incubator named “Le Catalyseur” to go deeply into the entrepreneurship project, working on the market strategy, the business model and the business plan. We were assisted in this task by Nicolas Delcey, the incubator coordinator and Eric Marchandier the director.

A banner

Start-Up incubator


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Figure 1: Logo of Le Catalyseur

For any startup project, an incubator is the best place to support and encourage the growth and achievements from the early stages to the real business. We had the opportunity to work with “Le Catalyseur”, a pre-incubator supporting undergraduate students which helps entrepreneurship project by providing resources, networking and advice. We benefited from resources and personal training to brainstorm our business vision of Cerberus, chaperoned by entrepreneurship specialists. Working with “Le Catalyseur” helped us to develop the right business application as seen on the business plan.

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Figure 2: From left to right Nicolas Delcey, Gaëlle Bordes and Angeline Pelus

Cerberus' Mission


The first workshops consisted of taking stock of our Cerberus project's progress, analyzing different domains of activity and defining the aim of the future company, using brand paper method. After thinking deeply, we all agreed that the mission of Cerberus would be to assist businesses to develop innovative materials using biosynthetic tools. Indeed, because we propose a wide range of functionalization we wish to target a large market and constantly offer innovations. Therefore, we chose to become a consulting company specialized in cellulose functionalization.

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Figure 3: iGEM Toulouse team meeting Le Catalyseur crew

Risk Analysis


The next workshop consisted of conducting a risk analysis allowing detection and analysis of threats and vulnerabilities which could affect Cerberus’ assets. The aim of this management approach was to find relevant countermeasures, depending on the impact we evaluated. In the previous workshop, we identified various domains of activity and we listed all the corresponding tasks. For the risk analysis we assessed each task, attributed them a grade reflecting risk exposure and the probability that the risk would happen. The table below corresponds to a summary of this workshop.

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Figure 4: Risk analysis table

The commercial domain shows the highest severity level because nobody in our iGEM team has a business or commercial profile. Therefore, it will be crucial to hire a sales representative in order to start the business.

In addition, before launching Cerberus on the market we need to improve the research and development aspect, even though we had great preliminary results and we provided proofs of concept of our project validity.

Business Model Canvas


The business model canvas is a tool allowing us to identify all the essential aspects of starting a business. This method is very useful and by presenting all the components of the company, the business model canvas works as a strategic tool. The structure of the document makes it easy to check the coherence of the project and to highlight its added value.

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Figure 1: Business Model Canvas of our project

The central bloc presents the value proposition, which means the selling propositions of the startup. In our case the Cerberus solution is an innovative method to functionalize cellulose using a cellulose- binding protein. We would provide advice and support in the design of linkers and on the cellulose fiber functionalizing function.

The four following blocs deal with external aspects, they are mainly linked to the market environment.

1 . Customer segments: Corresponds to the various market groups that would be interested in our Cerberus solution. They could be plant cellulose producers who want to add properties to their fibers. Because cellulose is present in various textile types such as clothing or bandages, we could target both the textile industry and the health industry. One of our proof of concept is to confer magnetic properties to cellulose. We also considered adding graphen or carbon nanotubes (CNT) to confer conductivity properties to cellulose. Therefore, we could also target the electronic component industry.

2 . Customer relationship: Because we would provide advice and conception design, our start-up would be a business to business company. We would establish three types of contract:

  • Support and advice contracts: We will offer our advice and accompaniment to the clients, and we will charge it per day.
  • R&D contract: Providing the design of a linker in terms of the client needs.
  • Production contract: Providing the linker produced by a partner.

3. Channels: This corresponds to the wide channels allowing the business to be discovered, deliver the value proposition, provide after-sales service. In our case it would be web sites, scientific publications, prospection, specialized forum or startup forum, and finally our professional network.

4. Revenue stream: Corresponds to the type of revenue generated from each customer segment. It would be product sales, patent sales, or right of exploitation. But it we could also collect money from bank loan of public investment.

Four blocs concern internal aspects.

5. Key partners: Corresponds to the network of partners and key suppliers the business model relies on. On the one hand, we need sub-contractors to scale up production of the linker before selling it to industrials. We would also need a research laboratory and a start-up incubator such as Toulouse White Biotechnology, allowing to continue R&D to improve the products and produce raw materials. On the other hand, we need partners such as an accounting firm, investors a business lawyer firm to protect our ideas and a health agency to prevent all possible risks.

6. Key activity: Corresponds to the most important things an organization needs to do to make its business model work. We identified two mains scientific activities: R&D and production. However, to run a business, we also need various activities such as Human resources, marketing, legal or financial activities.

7. Key resources: The most important assets required to run the organization’s business model. We identified four main aspects that correspond to the four main profiles of the co-founders of Cerberus business. However, the four co-founders have all done scientific studies, so marketing expertise will be missing. To begin the business, we will then either hire someone with a commercial profile or we will collaborate to have another co-founder.

8. Cost structure: This corresponds to the different costs inherent in the economic model. We identified various types such as basic reagent costs (molecular biology reagents, purification kits, culture media, …), equipment costs (PCR machines, electrophoresis apparatus, protein purification systems…) but also salaries and charges, certification audit and taxes. The distribution, the travel expenses to meet new customers by the sales representatives.

SWOT Analysis


The SWOT is a strategic tool allowing to put into perspective the internal characteristics of the business organization with the state of the environment in which it evolves. The SWOT makes it possible to anticipate strategic risks, to decide on a commercial positioning, or to refine an economic model.

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Figure 1: SWOT of our project

One of the main opportunity is the iGEM exposure in an international level. Indeed, we built a web site where we reported our entire project, from design to the demonstration of our work. Moreover, there is a real development of the financial contributions to help startup especially biotech research1. There is also a real demand for new fabrics, and textile market is constantly evolving to develop innovation2. The ecological aspect is more and more present and will be one of the major aspects that industries would have to consider. Also, one of the advantages of our project is the wide range of market and clients we would target. Therefore, the team has a strong formation in science and will have a large network from their university INSA, UPS and the After iGEM community.

Otherwise, we are not graduated yet and we have a lack of experience. Because we are scientists, we need to hire a marketing profile in order to have a different vision and a business expertise. Moreover, the field of biotechnology requires major investments for R&D and the risk is rather high, therefore companies are generally important laboratories with global influence. After the iGEM competition, which is open source, we will have some problems to effectively protect our work. Also, people have strong suspicions about GMO’s.

References

  1. Moedas, C. La biotechnologie industrielle, facteur de développement durable et de croissance verte. Annales des Mines - Réalités industrielles Février 2017, 5–7 (2017).
  2. Croissance du marché des textiles techniques: quelques tendances chiffrées. Mode in Textile (2018).

Business Plan


Before considering starting a business, we need to structure our idea to make it more concrete for ourselves, our future partners and our funders. Writing a business creation project consists of building a business plan. The business plan is a founding document that summarizes the essential element of the project including:

  • Market research
  • Commercial positioning
  • Economic model
  • Quantified projections

An error as occured, you may find the correct file here

Perspectives


Our combined efforts have enabled us to gain enough confidence to start our entrepreneurship journey. We started from scratch and through the months spent working on our project, consulting experts and planning our future, we gained solid experience in the domain of Synthetic Biology applications to new materials.

As our design has been validated by several proofs of concept, we can now think of all the possibilities that can emerge. We will first be a consulting company providing design and support to businesses, creating endless functionalization for cellulose based materials. We have established three types of service; support and advice contracts; R&D contracts and production contracts. Because we need more time to optimize the production of the protein depending on the client’s needs, we will fully develop this service in the near future.

As bacterial cellulose is a very promising material, we are probably at the beginning of the next trend in fashion or next generation textiles. So, as a long-term goal for the company, we can imagine a bacterial cellulose production to create clothes functionalized by our protein. Who knows, maybe this will become the next big thing?.

The frightened students that entered the iGEM Toulouse Team have now evolved; into lab scientists, project managers, accountants and molecular modelers. Of course, we still need stronger skills to make our company a success, but we are all excited about the perspectives offered by our entrepreneurship approach.

As iGEM has taught us, the key to success lies in hard work and determination to achieve our dreams. We will never forget this lesson as it has built the scientists we are today.