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− | <h5>Diphtheria is an infection caused by pathogenic bacterium <i>Corynebacterium diphtheriae</i>. The hallmark of diphtheria infection is pseudomembrane formation in posterior pharynx, potentially leading to respiratory tract obstruction and death. In addition, the bacterium produces toxin that enters cell via interaction with heparin-binding EGF-like growth factor (HB-EGF) receptor and inhibits protein synthesis, resulting in lethal complications such as myocarditis, bleeding problem, kidney and liver necrosis.</h5> | + | <h5><b>Diphtheria</b> is an infection caused by pathogenic bacterium <i>Corynebacterium diphtheriae</i>. The hallmark of diphtheria infection is pseudomembrane formation in posterior pharynx, potentially leading to respiratory tract obstruction and death. In addition, the bacterium produces toxin that enters cell via interaction with heparin-binding EGF-like growth factor (HB-EGF) receptor and inhibits protein synthesis, resulting in lethal complications such as myocarditis, bleeding problem, kidney and liver necrosis.</h5> |
<h5>Despite being preventable and curable, incidence and mortality rate caused by diphtheria are still increasing, especially in developing countries including Indonesia. Recently, there has been diphtheria outbreak affecting major provinces in Indonesia, mainly in unvaccinated children and adults. Therefore, there are two issues to be highlighted: (1) lack of early detection and prompt treatment of diphtheria infection and (2) lack of awareness regarding diphtheria and vaccination among Indonesian people.</h5> | <h5>Despite being preventable and curable, incidence and mortality rate caused by diphtheria are still increasing, especially in developing countries including Indonesia. Recently, there has been diphtheria outbreak affecting major provinces in Indonesia, mainly in unvaccinated children and adults. Therefore, there are two issues to be highlighted: (1) lack of early detection and prompt treatment of diphtheria infection and (2) lack of awareness regarding diphtheria and vaccination among Indonesian people.</h5> | ||
Revision as of 12:19, 16 October 2018