Difference between revisions of "Team:TUDelft"

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<h1 style="text-align:center"> Welcome to iGEM TU Delft 2018! </h1>
 
  
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<p style="text-align:center"><img src="https://static.igem.org/mediawiki/2018/1/10/T--TUDelft--2018_adopewithtext.png" alt="adope_logo" style="width:50%"/></p>
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<p style="text-align:justify">Rapid developments in synthetic biology continue to offer solutions for multidisciplinary platforms. Gene therapy, as one of the many applications, is a promising method for the rapid improvement of human health. However, with powerful technology comes great responsibility: unethical and undesired applications of synthetic biology have remained prevalent ever since its emergence. Among these, abuse of gene therapy by athletes to improve sports performances, also known as gene doping, is a rising trend as an innovative doping strategy.  
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Gene doping has already caught the preventional attention of the World Anti-Doping Authority (WADA) in 2003, leading to its addition to the Prohibited List for professional sporters. Extensive research efforts have been conducted to develop detection methods. However, they remain prone to failure in detecting the potential diversity of gene doping (e.g, splicing patterns, promoter choices and codon optimization). Currently, the implementation of gene doping detection is explored by the doping authorities, but there is still a large need for the development of robust and reliable methods.
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This year, the iGEM team TU Delft aims to develop a routine, reliable and robust method for the detection of gene doping. The method Advanced Detection of Performance Enhancement, “ADOPE”, is based on targeted next-generation sequencing, using a technically unique and innovative CRISPR-Cas - Transposase fusion protein. The specificity of the Cas-protein ensures that only the targeted gene doping DNA will be edited in the necessary specific way by the transposase desired for sequencing. Our technology is developed in a way that ensures the possibility of detecting any foreign DNA as long as gRNAs are provided accordingly, which allows for the flexible application of the technique beyond gene doping detection.
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<p style="text-alignment:center"><img src="https://static.igem.org/mediawiki/2018/f/f8/T--TUDelft--2018_fusionfunction.png" alt="Fusion Protein"/></p>
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<header id="showcase" class="hidden-xs">
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<div class="overlaycontainer " class="text-center">
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    <div id="fadein1">On your marks.</div>
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    <div id="fadein2">Get set.</div>
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    <div id="fadein3">Detect.</div>
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    <div id="fadein4">Join the race against gene doping.</div>
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    <div class="text-block2">
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    <img src="https://static.igem.org/mediawiki/2018/c/ca/T--TUDelft--2018_TUDelft.png" class="tulogo"></div>
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    <img src="https://static.igem.org/mediawiki/2018/c/c6/T--TUDelft--2018_adope_logo_black.png"></div>
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    <div class="rdmrbttn"><a href="#getstarted" class="britney">Read More <i class="fas fa-angle-double-down"></i></a></div>
 
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<header id="showcase2" class="hidden-lg hidden-md hidden-sm">
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<div class="overlaycontainer " class="text-center">
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    <div id="jointherace"><br>Join the race against gene doping.</div>
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    <div class="tulogosmall">
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    <img src="https://static.igem.org/mediawiki/2018/c/ca/T--TUDelft--2018_TUDelft.png" class="tulogo2 img-responsive"></div>
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    <!--<div class="adopesmall">
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    <img src="https://static.igem.org/mediawiki/2018/c/c6/T--TUDelft--2018_adope_logo_black.png" class="adopelogo2 img-responsive" ></div>-->
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    <div class="rdmrbttn2"><a href="#getstarted" class="britney">Read More <i class="fas fa-angle-double-down"></i></a></div>
 
</div>
 
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<br>
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    <div class="col-lg-2 col-md-2 col-sm-1 xs-hidden"></div>
  
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    <div class="col-lg-8 col-md-8 col-sm-10 col-xs-12">
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        <center><h3 style="text-align:center;">Introducing ADOPE<br><em>Advanced Detection Of Perfomance Enhancement</em></h3>
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        <img src="https://static.igem.org/mediawiki/2018/b/b1/T--TUDelft--2018_scanning.gif" class="img-fluid" style="margin:40px">
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        <br><h3>We are fighting for honest athletes and clean sports by detecting gene doping <br> a rising threat to fair sport.</h3></center>
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<br>
  
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<div style="border:solid 4px #FFFFFF;padding:20px;margin:20px;">
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    <div class="rdmrbttn" id="moremore"><a href="#ourparts" class="britney">Learn more about ADOPE <i class="fas fa-angle-double-down"></i></a></div>
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<div class="column full_size" >
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<p>As long as we are working on our wiki, please visit us on our <a href="http://igemtudelft.nl">website</a>! :)</p>
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<p>You can also give us a call <i>+31 (0)15 278 5394</i> or contact us via our (social) media platforms:<br><br>
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<a href="https://www.facebook.com/TUDelft.iGEM2018/" target="_blank" rel="noopener"><img style="width: 5%; padding-right: 10px;" src="https://static.igem.org/mediawiki/2018/7/71/T--TUDelft--2018_fbicontudelft.png" alt="Facebook" /></a> <a href="https://www.linkedin.com/company/igem-tu-delft/" target="_blank" rel="noopener"><img style="width: 5%; padding-right: 10px;" src="https://static.igem.org/mediawiki/2018/6/6d/T--TUDelft--2018_linkedinicontudelft.png" alt="LinkedIn" /></a> <a href="https://www.instagram.com/igemtudelft/?hl=en" target="_blank" rel="noopener"><img style="width: 5%; padding-right: 10px;" src="https://static.igem.org/mediawiki/2018/9/91/T--TUDelft--2018_instaicontudelft.png" alt="Instagram" /></a> <a href="https://twitter.com/TUDelft_iGEM?lang=en" target="_blank" rel="noopener"><img style="width: 5%; padding-right: 10px;" src="https://static.igem.org/mediawiki/2018/7/7b/T--TUDelft--2018_twittericontudelft.png" alt="Twitter" /></a> <a href="mailto:tudelft.igem@gmail.com"><img style="width: 5%; padding-right: 10px; padding-bottom: 5px;" src="https://static.igem.org/mediawiki/2018/3/37/T--TUDelft--2018_mailicontudelft.png" alt="Email" /></a></p>
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    <div class="col-lg-8 col-md-8 col-sm-10 col-xs-12">
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      <br><br><br>
 +
        <h3 style="text-align:center;">Learn more about each unique part of our project.</h3>
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        <br>
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    </div>
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    <div class="col-lg-2 col-md-2 col-sm-1 xs-hidden"></div>
 
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                <img src="https://static.igem.org/mediawiki/2018/2/21/T--TUDelft--2018_GifFusion.gif" alt="Fusion protein">
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                <div class="caption">
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                    <h3 class="adpbl"><a href="https://2018.igem.org/Team:TUDelft/Description" class="adpbl">How-to: Detect gene doping</a></h3>
 +
                    <p class="introp">With our newly designed <b>CRISPR-Cas based fusion protein</b>, we developed a next-generation <b>targeted sequencing platform</b>. Find out all the measures we took to bring our project to perfection.<br> </p>
 +
                </div>
 +
        </div>
 +
    </div>
 +
    <div class="col-sm-4 col-md-4 col-xs-12">
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            <div class="thumbnail">
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                <img src="https://static.igem.org/mediawiki/2018/d/d8/T--TUDelft--modelcut.png" alt="...">
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                <div class="caption">
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                <h3 class="adpbl"><a href="https://2018.igem.org/Team:TUDelft/Model" class="adpbl">iGEM TU Delft's next top model</a></h3>
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                <p class="introp">Our wetlab and <b>drylab</b> are working side by side when it comes to gene doping detection. Find out how both parts influenced each other and how we <b>simulated</b> the entire doping process within the human body. </p>
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</div>
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</div>
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</div>
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    <div class="col-sm-4 col-md-4 col-xs-12">
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            <div class="thumbnail">
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                <img src="https://static.igem.org/mediawiki/2018/1/10/T--TUDelft--Moniekuncut.jpg" alt="...">
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                <div class="caption">
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                <h3 class="adpbl"><a href="https://2018.igem.org/Team:TUDelft/Human_Practices" class="adpbl">Everything you need to know about our Human Practices</a></h3>
 +
                <p class="introp">During our iGEM season, we actively involved <b>stakeholders</b> and the public with our project. Read more about the interesting people we met and how each of them <b>contributed</b>.<br></p>
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        <center><div clas="container" style="position:relative;"><img src="https://static.igem.org/mediawiki/2018/a/a1/T--TUDelft--2018_col_v2.png" alt="Circle of Life" usemap="#CircleOfLife" id="CircleLife" style="height:75%;length:auto;"><a href="https://2018.igem.org/Team:TUDelft/Description" title="Project" style="position: absolute; left: 30.83%; top: 4%; width: 38.63%; height: 18.65%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Description" title="Project" style="position: absolute; left: 42.82%; top: 22.65%; width: 14.37%; height: 17.6%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Model" title="Modeling" style="position: absolute; left: 11.23%; top: 26.93%; width: 18.93%; height: 27.02%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Model" title="Model" style="position: absolute; left: 30.35%; top: 36.25%; width: 9.51%; height: 16.65%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Experiments" title="Wetlab" style="position: absolute; left: 59.85%; top: 35.97%; width: 33.59%; height: 15.79%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Experiments" title="Wetlab" style="position: absolute; left: 70.79%; top: 25.31%; width: 20.93%; height: 10.28%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Parts" title="Parts" style="position: absolute; left: 32.73%; top: 58.04%; width: 16.94%; height: 31.97%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Parts" title="Parts" style="position: absolute; left: 19.41%; top: 60.89%; width: 12.37%; height: 23.12%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Human_Practices" title="HP" style="position: absolute; left: 49.95%; top: 56.04%; width: 18.55%; height: 37.68%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Human_Practices" title="HP" style="position: absolute; left: 69.36%; top: 64.13%; width: 13.32%; height: 21.41%; z-index: 2;"></a><a href="https://2018.igem.org/Team:TUDelft/Human_Practices" title="HP" style="position: absolute; left: 84.21%; top: 90.2%; width: 10.85%; height: 4.28%; z-index: 2;"></a></div>
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{{:Team:TUDelft/Footer2}}

Revision as of 00:12, 18 October 2018

ADOPE


Introducing ADOPE
Advanced Detection Of Perfomance Enhancement


We are fighting for honest athletes and clean sports by detecting gene doping
a rising threat to fair sport.





Learn more about each unique part of our project.


Fusion protein

How-to: Detect gene doping

With our newly designed CRISPR-Cas based fusion protein, we developed a next-generation targeted sequencing platform. Find out all the measures we took to bring our project to perfection.

...

iGEM TU Delft's next top model

Our wetlab and drylab are working side by side when it comes to gene doping detection. Find out how both parts influenced each other and how we simulated the entire doping process within the human body.

...

Everything you need to know about our Human Practices

During our iGEM season, we actively involved stakeholders and the public with our project. Read more about the interesting people we met and how each of them contributed.