Team:Lethbridge/Software

Protein Nanocompartment Designer

Lethbridge iGEM 2018

The purpose of this tool is to facilitate a match between molecular cargo and cellular target and provide a protein nanocompartment recommendation as a starting point for the design of your own VINCEnT! The tool accepts user input to specify the cellular target, molecular cargo, and approximate size of the protein nanocompartment. After submitting, a recommendation will be generated and will provide a link to a datasheet with information on the PNC.

For instance, specifying a protein cargo, to be delivered to bacteria, greater than 60nm radius should recommend the capsid of Bacteriophage P22 for this application.

Software Tool

Target Mammal Bacteria Plant

Size Range 15-30nm 30-60nm >60nm

Cargo Sequence

Submit

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Based on your input we were to recommend for your application.

Remember, biology is a cooperative endeavour. When people aren't careful with the biology they do, it can have long lasting effects on everyone else. Accordingly, you should be very careful about encapsulating nucleic acids that are able to self-replicate or integrate into a genome. Ideally, a PNC should be used to carry single-use cargo. For instance, encapsulating a gene drive, transposable element, or other heritable element is strongly discouraged.

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