Team:DLUT China

igem | DLUT_China


Character 1: An annoying monster

Hyperuricemia is an annoying monster. It is a representation of abnormally high levels of uric acid in the blood and is best at attacking human joints, which can cause acute gout arthritis, chronic gout arthritis and even joint deformities. However, this is only the tip of the iceberg of evil damage. It can also damage the kidney, cause abnormal renal function, cause chronic kidney diseases such as renal stone and renal colic, and is closely related to metabolic diseases such as hypertension, diabetes, heart disease, cerebrovascular disease and fatty liver.

Character 2: Knight of limited ability

The various forces currently battling hyperuricemia show their deficiencies: side effects, drug resistance, painful treatment processes, and so on. Therefore, we all look forward to the hero who can truly defeat hyperuricemia.

Character 3: Urate Oxidase-a new hero
The Urate Oxidase will be the hero, an enzyme in organisms that catalyzes the oxidation of uric acid in purine metabolism. It can oxidize uric acid to 5-hydroxy iso-uric acid, an unstable compound that is readily converted to allantoin in organisms. Allantoin can be easily metabolized by the kidney, thus lowering the body's blood uric acid level. When uric acid oxidase attacks hyperuricemia, the target of action is uric acid itself, so it will not hurt the body.

Our Work

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Step 1

We introduced plasmids containing signaling peptides, osmotic peptides and uric acid oxidase genes into E.coli.

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Step 2

We add E. coli to drinks like milk so patients will take it painlessly

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Step 3

These coliform bacteria will accumulate in the gut and form a community here.

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Step 4

Whenever the blood acid concentration is high,E.coli will automatically monitor and secrete uric acid oxidase to reduce the blood acid concentration.