Our collaborations

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iGEM Montpellier

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iGEM Montpellier

Vagineering : A New Non Hormonal Contraception

Abtract

Modern hormonal contraceptive methods have been revolutionary for women in developed countries; however, they still exhibit a variety of challenges. Developing countries lack consistent access, hormonal contraceptives can produce harmful environmental effects, and some women are unable use them due to health problems. The Vagineering project looks to solve these issues with a novel, non-hormonal method. Our team aims to engineer Lactobacillus jensenii, a bacterium from the vaginal flora, to produce two proteins to prevent unintentional pregnancy: antisperm antibodies that inhibit sperm motility and anti-microbial peptides (AMPs) that produce spermicidal effects. The goal is to create a lasting contraceptive using only bacteria, which can later be reversed by engineering the strain with a kill-switch. Additionally, our studies of this strain have produced a toolbox that will help other teams to further engineer this less-characterized bacterium.

https://2018.igem.org/Team:Montpellier

Haec subinde Constantius audiens et quaedam referente Thalassio doctus, quem eum odisse iam conpererat lege communi, scribens ad Caesarem blandius adiumenta paulatim illi subtraxit, sollicitari se simulans ne, uti est militare otium fere tumultuosum, in eius perniciem conspiraret, solisque scholis iussit esse contentum palatinis et protectorum cum Scutariis et Gentilibus, et mandabat Domitiano, ex comite largitionum, praefecto ut cum in Syriam venerit, Gallum, quem crebro acciverat, ad Italiam properare blande hortaretur et verecunde.

iGEM IIT Madras

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iGEM IIT Madras

ADaPtat1on : Expanding Toolkit for Acinetobacter baylyi

Abtract

Acinetobacter baylyi is a gram-negative, soil-dwelling, non-pathogenic, naturally competent and nutritionally versatile organism especially known for its ability to degrade aromatic compounds. However, only a few tools are available for its gene manipulation. This year, we plan to expand the toolkit for A. baylyi ADP1 by making a synthetic promoter library along with codon optimized fluorescent reporter proteins to achieve better control over its expression rates. The codon table is not available for this organism. So we obtained sequence data of well-characterised proteins of this organism by filtering manually putative and hypothetical sequences and used this data to generate the codon table using CUTE - a tool of ChassiDex. The codon optimisation is done manually by replacing the less frequent codons with high-frequency codons based on the generated table. This can potentially open up various new exciting synthetic biology opportunities with this unexplored organism.

https://2018.igem.org/Team:IIT-Madras

Haec subinde Constantius audiens et quaedam referente Thalassio doctus, quem eum odisse iam conpererat lege communi, scribens ad Caesarem blandius adiumenta paulatim illi subtraxit, sollicitari se simulans ne, uti est militare otium fere tumultuosum, in eius perniciem conspiraret, solisque scholis iussit esse contentum palatinis et protectorum cum Scutariis et Gentilibus, et mandabat Domitiano, ex comite largitionum, praefecto ut cum in Syriam venerit, Gallum, quem crebro acciverat, ad Italiam properare blande hortaretur et verecunde.

iGEM Duesseldorf

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iGEM Duesseldorf

Trinity - towards an engineered co-culture toolbox

Abtract

Co-cultures are found in all conceivable entities, such as the human gut, cheese or plants, but good tools to study those communities are currently not given. Indeed we created a modularly built toolbox using not only three different dependencies but also three different organisms: With Escherichia coli, Saccharomyces cerevisiae and Synechococcus elongatus our team engineered a system based on nutrient exchange. Here phosphate is provided through oxidation of phosphite, nitrogen source produced by melamine breakdown, whilst carbon source is provided by Synechococcus elongatus. Two additional independent approaches are designed, too. The first includes regulation via cross-feeding by amino acid auxotrophies and production: lysine by Escherichia coli and leucine by Saccharomyces cerevisiae. The other utilizes regulated self-lysis via quorum sensing molecules, to control cell density by a phage lysis gene. This engineered toolbox opens a wide range of possibilities to create microbial communities for different purposes, such as synthetic probiotics.

https://2018.igem.org/Team:Duesseldorf

Haec subinde Constantius audiens et quaedam referente Thalassio doctus, quem eum odisse iam conpererat lege communi, scribens ad Caesarem blandius adiumenta paulatim illi subtraxit, sollicitari se simulans ne, uti est militare otium fere tumultuosum, in eius perniciem conspiraret, solisque scholis iussit esse contentum palatinis et protectorum cum Scutariis et Gentilibus, et mandabat Domitiano, ex comite largitionum, praefecto ut cum in Syriam venerit, Gallum, quem crebro acciverat, ad Italiam properare blande hortaretur et verecunde.

iGEM Pasteur

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iGEM Pasteur

NeuronArch:
the novel connecting and protecting biofilm based system for prostheses

Abtract

In the future, a long due consideration and an easier access to healthcare will be given to people with disabilities. Presently, some prostheses allow amputees to perform simple actions but without a direct connection between the nerves and the prosthesis. Furthermore, a major health risk is the development of pathogenic communities of microorganisms in structures called biofilms. Strong treatments with antibiotics, or even surgical reinterventions are then required. They represent a heavy burden for both the patient and the healthcare system. We imagined NeuronArch as a novel application that subverts potential pathogenic biofilms using an engineered one. This interface produces substances called neurotrophins (NGF), for directed and controlled growth of nerves. Using a conductive membrane, it will also allow passing of information and enhancement of the electrical properties. Altogether, these improvements would enable patients to regain natural perceptions and prevent the formation of Staphylococcus aureus biofilms by blocking quorum sensing.

https://2018.igem.org/Team:Pasteur_Paris

Haec subinde Constantius audiens et quaedam referente Thalassio doctus, quem eum odisse iam conpererat lege communi, scribens ad Caesarem blandius adiumenta paulatim illi subtraxit, sollicitari se simulans ne, uti est militare otium fere tumultuosum, in eius perniciem conspiraret, solisque scholis iussit esse contentum palatinis et protectorum cum Scutariis et Gentilibus, et mandabat Domitiano, ex comite largitionum, praefecto ut cum in Syriam venerit, Gallum, quem crebro acciverat, ad Italiam properare blande hortaretur et verecunde.

Meeting

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