Difference between revisions of "Team:Pasteur Paris/Entrepreneurship"

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<div class="block full"><p><i>Since we feel NeuronArch is a promising project in the field of biotechnology and prosthetics, we envisioned it a startup company and designed a business plan accordingly to the experience we had this year participating at iGEM.</i></p></div>
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<div class="block full"><p><i>Since we feel NeuronArch is a promising project in the field of biotechnology and prosthetics, we envisioned it as a startup company and designed a business plan accordingly to the experience we had this year participating at iGEM.</i></p></div>
 
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<p>Even though leg prosthetics are becoming more and more efficient and sophisticated, allowing amputees to even participate to Olympic Race, arm prosthetics have not evolved that much from the last century, usually equipped on the torso with a harness and not that much practical. While biomechanical prosthetics are slowly interring the market, bionic prosthetics are still missing because current technology do not allow a direct connection between the amputated limb’s nerves and the prosthetics itself. Osseointegrated prosthetics may be the field allowing this connection but the risk of infection by pathogenic biofilms on this type of interface is very high, requiring a heavy antibiotic treatment and removal of the osseointregrated prosthetic. To answer this problem, we used synthetic biology to create an engineered biofilm able to stimulate nerve regrowth after amputation but also reducing the risk of the formation of a pathogenic biofilm. </p>
 
<p>Even though leg prosthetics are becoming more and more efficient and sophisticated, allowing amputees to even participate to Olympic Race, arm prosthetics have not evolved that much from the last century, usually equipped on the torso with a harness and not that much practical. While biomechanical prosthetics are slowly interring the market, bionic prosthetics are still missing because current technology do not allow a direct connection between the amputated limb’s nerves and the prosthetics itself. Osseointegrated prosthetics may be the field allowing this connection but the risk of infection by pathogenic biofilms on this type of interface is very high, requiring a heavy antibiotic treatment and removal of the osseointregrated prosthetic. To answer this problem, we used synthetic biology to create an engineered biofilm able to stimulate nerve regrowth after amputation but also reducing the risk of the formation of a pathogenic biofilm. </p>

Revision as of 11:35, 5 October 2018

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Since we feel NeuronArch is a promising project in the field of biotechnology and prosthetics, we envisioned it as a startup company and designed a business plan accordingly to the experience we had this year participating at iGEM.

Even though leg prosthetics are becoming more and more efficient and sophisticated, allowing amputees to even participate to Olympic Race, arm prosthetics have not evolved that much from the last century, usually equipped on the torso with a harness and not that much practical. While biomechanical prosthetics are slowly interring the market, bionic prosthetics are still missing because current technology do not allow a direct connection between the amputated limb’s nerves and the prosthetics itself. Osseointegrated prosthetics may be the field allowing this connection but the risk of infection by pathogenic biofilms on this type of interface is very high, requiring a heavy antibiotic treatment and removal of the osseointregrated prosthetic. To answer this problem, we used synthetic biology to create an engineered biofilm able to stimulate nerve regrowth after amputation but also reducing the risk of the formation of a pathogenic biofilm.

Figure 1: Estimating limb loss by age. Year 2005, United States. (A) Total repartition of limb loss in people under and over 65 years old. (B) Limb loss in people under 18 years old, between 18 and 44 years old and between 45 and 64 years old. (C) Limb loss in people between 65 and 74 years old and between 75 and 100 years old. Note: Totals may not equal sum because of rounding. *Represents less than 1000.

Before bringing NeuronArch to an industrial level, we first evaluated our target market, depending on the number of amputation and realized that our device, which would mainly be used by young/active people, was only a minority of the amputations. In fact, 57% of amputees [1] are under 65 years old, and in this group, 66.5% are between the age of 45 and 64 years old while only 30% are between the age of 18 and 44 years old (Cf. Figure 1).

However, the osseotintegrated implant market is expected to grow at a compound annual growth rate of 4% between 2013 and 2023 [2]. The global market for orthopedic prosthetics is expected to witness moderate growth rate in term of value owing to increasing incidence of trauma / accidental injuries (Cf. Table 1)

Etiology and Age 2005 2010 2020 2050
Total 1568 1757 2213 3627
Dysvascular Disease Total 846 969 1285 2272
Dysvascular Disease with Comorbidity of Diabetes 592 674 899 1667
Trauma 704 769 906 1326
Cancer 18 19 22 29
Table 1: Projected Prevalence of Limb Loss by Etiology and Age (in thousands). Years 2005, 2010, 2020, 2050, United States. Numbers extracted from Prescient Strategic Intelligence, “Osseintegration Implants Market” (2018)

Introduction of custom-made implant products (rising demands for advanced orthopedic prosthetics, favorable reimbursement for orthopedic prosthetics, rise in prevalence of lifestyle related diseases and disorders, growing focus on containment of healthcare costs and distribution & collaboration agreements to increase product reach driving global revenues) is creating high potential growth opportunities for players operating in global orthopedic prosthetics market. Spur in the disposable household income in the emerging economies are expected to provide ample opportunities to the manufacturers operating in the osseointegrated implants market.

We feel our interface NeuronArch could respond to this demand, and tried our best to tackle every issue that comes with trying to bring NeuronArch to the industrial scale.

In the Business Plan, that you can download here, you will find a Market Analysis, Study of possible competition by private companies, our Marketing Plan, our Sales Plan, our Operations, details on our Company, as well as our Financial Plan.

REFERENCES

  • Kathryn Ziegler-Graham, Ellen J. MacKenzie, Patti L. Ephraim, Thomas G. Travison, Ron Brookmeyer. Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050, Archives of Physical Medicine and Rehabilitation (2008). Volume 89, Issue 3, Pages 422-429.

  • Prescient Strategic Intelligence, “Osseintegration Implants Market” (2018) Retrieved Sep. 10th 2018 from https://www.psmarketresearch.com/market-analysis/osseointegration-implants-market