Difference between revisions of "Team:Pasteur Paris/Device"

 
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<h1>DEVICE AND APP</h1>
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                <img class="banner-img" src="https://static.igem.org/mediawiki/2018/a/a4/T--Pasteur_Paris--Banner_Device.jpg">
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<p><a href="#Implant" class="link">Implanting Functional Stem</a></p>
 
<p><a href="#Implant" class="link">Implanting Functional Stem</a></p>
 
<p><a href="#Connect" class="link">Connection to Stump</a></p>
 
<p><a href="#Connect" class="link">Connection to Stump</a></p>
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<p><a href="#Recharge" class="link">Recharging Station</a></p>
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<p><a href="#Recharge" class="link">Charging Station</a></p>
 
<p><a href="#Smartphone" class="link">Smartphone & Web App</a></p>
 
<p><a href="#Smartphone" class="link">Smartphone & Web App</a></p>
 
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<i><p>We designed a global proposal, thinking of dimensions, materials, fabrication processes, always taking into consideration the industrial and medical feasibility and the user’s comfort. Our system includes an implantation stem featuring our engineered biofilm, an interface device to collect and process the signal from nerves, and also connect the future prosthesis. A charging station and an app are also part of our setup.</p></i>
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</div>
 
<div class="block title" id="Implant"><h3 style="text-align: left;">Implanting a functional stem</h3></div>
 
<div class="block title" id="Implant"><h3 style="text-align: left;">Implanting a functional stem</h3></div>
 
<div class="block full">
 
<div class="block full">
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<p>
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<p>To connect our device to the user’s stump, we designed a fully functional osseointegrated stem.
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To connect our device to the user’s stump, we designed a technical piece, a fully functional stem, that is osseointegrated. <br>
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This internal device needs an extremely high precision for machining parts. Indeed, biofilm and membrane’s nanometric scales and necessity to extend a member leads to constraining strength and precision’s placement. Directly in contact with bone, sintered ceramic’s part links the bone and the titanium stem together (Figure1). Where the stem emerges from the bone, its diameter enlarges to increases from 6mm to 10mm. The biofilm takes place in the few centimeters available between bone and skin. It is contained by a hemi-permeable membrane. The latter, in PEDOT: PSS, is the surface upon which the nerves come to fixate. This also allows the nervous current to traduce to an electrical current. This membrane is placed around the tube and conducts the signal to the outside (Figure 2).<br>
+
 
</p>
 
</p>
 +
<p>This internal device needs an extremely high precision for machining parts. Indeed, the biofilm and the membrane’s nanometric scales, coupled with the necessity to extend a member, lead to constraining strength and precision’s placement. Directly in contact with bone, the sintered ceramic part links the bone and the titanium stem together (Figure1). Where the stem emerges from the bone, its diameter expands, increasing from 6 mm to 10 mm. The biofilm occupies the space in the few centimeters available between the bone and the skin. It is contained by a nanoporous membrane. The latter, made of PEDOT: PSS, is the surface upon which the nerves will come to fixate. This also allows the electric nerve current to be transformed into an electrical current on the membrane. This membrane is placed around the tube and will conduct the signal to the outside(Figure 2).</p>
 +
<p>The titanium implanted tube, which is biocompatible, has a resistance as measured by it Young’s modulo of 193 GPa, and a low density of 4510 Kg/M<sup>3</sup> compared to biocompatible stainless steel with  114 GPa and 800 Kg/M<sup>3</sup>. </p>
 
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<img src="">
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<img src="https://static.igem.org/mediawiki/2018/5/56/T--Pasteur_Paris--Device_Figure_1.svg">
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<div class="legend"><b>Figure 1: </b>diagram of the implantation’s system parts</div>
 
</div>
 
</div>
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<div class="block full">
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<img src="">
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<img src="https://static.igem.org/mediawiki/2018/b/b3/T--Pasteur_Paris--Device_Figure_2.svg">
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<div class="legend"><b>Figure 2: </b>Implantation’s sectional view  </div>
 
</div>
 
</div>
  
 
<div class="block title" id="Connect"><h3 style="text-align: left;">Connecting the device to the stump</h3></div>
 
<div class="block title" id="Connect"><h3 style="text-align: left;">Connecting the device to the stump</h3></div>
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<div class="block full">
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<div class="block one-third">
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<p></p>
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<p>Once the nerves signal is conducted by the electrical wires, it has to be treated and amplified. This is done into an interface device placed between the stump and the bionic prosthesis. </p>
 +
<p>As for the NeuronArch interface device, we chose ABS (Acrylonitrile-Butadiene-Styrene) as the main material. We wanted to use an injection moldable plastic to reduce the cost of machining as well as for providing interesting properties for our project such as weight reduction, heat and shock resistance..</p>
 
</div>
 
</div>
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<img src="">
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<img src="https://static.igem.org/mediawiki/2018/3/31/T--Pasteur_Paris--Device_Figure_3.svg">
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<div class="legend"><b>Figure 3: </b>Exploded drawing of NeuronArch’s interface device</div>
 
</div>
 
</div>
  
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<div class="block title" id="Recharge"><h3 style="text-align: left;">Recharging station</h3></div>
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<div class="block title" id="Recharge"><h3 style="text-align: left;">Charging and synchronizing the interface device</h3></div>
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<p></p>
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<p>In order to recharge the NeuronArch device, we designed an induction charging station, that includes a power outlet connectable by a USB-C plug. The compatible loading station is made of ABS and is used for patient data synchronization. It also features a small elevation on the housing that allows the NeuronArchinterface device to be perfectly engaged and stable while charging and synchronizing. For storing cables during transportation we anticipated an elastic strip on the back of the station. </p>
 
</div>
 
</div>
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<div class="block full">
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<div class="block two-third">
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<img src="">
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<img src="https://static.igem.org/mediawiki/2018/6/6a/T--Pasteur_Paris--Device_Figure_4.svg">
 +
<div class="legend"><b>Figure 4: </b>Exploded drawing of NeuronArch charging station</div>
 
</div>
 
</div>
  
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<div class="block title" id="Smartphone"><h3 style="text-align: left;">Smartphone and web app</h3></div>
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<div class="block title" id="Smartphone"><h3 style="text-align: left;">Consulting and monitoring data</h3></div>
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<div class="block full"></div>
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<div class="block full">
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<p></p>
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<img src="https://static.igem.org/mediawiki/2018/e/ec/T--Pasteur_Paris--Device_Figure_5.svg">
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<div class="legend"><b>Figure 5: </b>App’s connection diagram </div>
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</div>
 
</div>
 
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Latest revision as of 11:58, 14 October 2018

""

We designed a global proposal, thinking of dimensions, materials, fabrication processes, always taking into consideration the industrial and medical feasibility and the user’s comfort. Our system includes an implantation stem featuring our engineered biofilm, an interface device to collect and process the signal from nerves, and also connect the future prosthesis. A charging station and an app are also part of our setup.

Implanting a functional stem

To connect our device to the user’s stump, we designed a fully functional osseointegrated stem.

This internal device needs an extremely high precision for machining parts. Indeed, the biofilm and the membrane’s nanometric scales, coupled with the necessity to extend a member, lead to constraining strength and precision’s placement. Directly in contact with bone, the sintered ceramic part links the bone and the titanium stem together (Figure1). Where the stem emerges from the bone, its diameter expands, increasing from 6 mm to 10 mm. The biofilm occupies the space in the few centimeters available between the bone and the skin. It is contained by a nanoporous membrane. The latter, made of PEDOT: PSS, is the surface upon which the nerves will come to fixate. This also allows the electric nerve current to be transformed into an electrical current on the membrane. This membrane is placed around the tube and will conduct the signal to the outside(Figure 2).

The titanium implanted tube, which is biocompatible, has a resistance as measured by it Young’s modulo of 193 GPa, and a low density of 4510 Kg/M3 compared to biocompatible stainless steel with 114 GPa and 800 Kg/M3.

Figure 1: diagram of the implantation’s system parts
Figure 2: Implantation’s sectional view

Connecting the device to the stump

Once the nerves signal is conducted by the electrical wires, it has to be treated and amplified. This is done into an interface device placed between the stump and the bionic prosthesis.

As for the NeuronArch interface device, we chose ABS (Acrylonitrile-Butadiene-Styrene) as the main material. We wanted to use an injection moldable plastic to reduce the cost of machining as well as for providing interesting properties for our project such as weight reduction, heat and shock resistance..

Figure 3: Exploded drawing of NeuronArch’s interface device

Charging and synchronizing the interface device

In order to recharge the NeuronArch device, we designed an induction charging station, that includes a power outlet connectable by a USB-C plug. The compatible loading station is made of ABS and is used for patient data synchronization. It also features a small elevation on the housing that allows the NeuronArchinterface device to be perfectly engaged and stable while charging and synchronizing. For storing cables during transportation we anticipated an elastic strip on the back of the station.

Figure 4: Exploded drawing of NeuronArch charging station

Consulting and monitoring data

Figure 5: App’s connection diagram