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<div class="block title"><h3 style="text-align: left;">Designing the interface between the tissues and the prosthetis</h3></div> | <div class="block title"><h3 style="text-align: left;">Designing the interface between the tissues and the prosthetis</h3></div> | ||
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− | <p>When we started to think about the scientific aspect of our project, we also started to design and think about how our biofilm would integrate into a physical medical device. First, we wanted to design a full prosthesis. We realized that it wasn’t the core of the problem. Indeed, the technology missing in this field was the actual interface between the prosthesis and the osseointegrated steel/titanium/ceramic stem inside the human body, limiting the field of the bionic prosthesis. We decided to focus on this interface and started to talk with Dr. Benjamin Bouyer, a lumbar rachis surgeon, on how we could deposit the biofilm on or in the osseointegrated stem. We realized that the stem would be in direct contact with the surgeon meaning that if we coated the whole structure with our biofilm, it would probably be stripped off, get deposited on the gloves and contaminate other areas. We also spoke with one member of the board of directors of ADEPA, “Association de Défense et d’Etude des Personnes Amputés », which translates to « Association for the Defense and Study of Amputated Persons” who is himself an amputee. He gave us great advice on the designing phase of this interface and raised the issue of the socket causing excessive sudation and discomfort for the patient. After meeting with experts from | + | <p>When we started to think about the scientific aspect of our project, we also started to design and think about how our biofilm would integrate into a physical medical device. First, we wanted to design a full prosthesis. We realized that it wasn’t the core of the problem. Indeed, the technology missing in this field was the actual interface between the prosthesis and the osseointegrated steel/titanium/ceramic stem inside the human body, limiting the field of the bionic prosthesis. We decided to focus on this interface and started to talk with Dr. Benjamin Bouyer, a lumbar rachis surgeon, on how we could deposit the biofilm on or in the osseointegrated stem. We realized that the stem would be in direct contact with the surgeon meaning that if we coated the whole structure with our biofilm, it would probably be stripped off, get deposited on the gloves and contaminate other areas. We also spoke with one member of the board of directors of ADEPA, “Association de Défense et d’Etude des Personnes Amputés », which translates to « Association for the Defense and Study of Amputated Persons” who is himself an amputee. He gave us great advice on the designing phase of this interface and raised the issue of the socket causing excessive sudation and discomfort for the patient. After meeting with experts from i.CERAM (Ceramic medical devices company, Limoges, France) and the CERAH (Center for Studies and Research on the Equipment for the Handicapped), we learned more and more about the different materials used in the making of prostheses. At this point, we realized that doing a full stainless-steel interface would stimulate the growth of bacteria in a biofilm structure. Therefore, we decided to switch and do the part in direct contact with the patient in ceramic, knowing that we still have the same problem that i.CERAM and the CERAH were facing currently. Indeed, steel doesn’t last as much as ceramic, which could be a problem when creating an interface composed of both materials. We knew then that the patient would probably need corrective surgeries to fix his osseointegrated stem. Having considered these parameters, we then decided to start modeling our prototype by integrating those different aspects as much as possible. Because we wanted it to be cost-effective and injection-moldable, we want to build our future prototypes in ABS, a thermoplastic polymer that could be molded by injection. We ordered the electronic parts composed of a charger, battery, and amplifier, and assembled it into its current state as our POC. </p> |
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<img src="https://static.igem.org/mediawiki/2018/d/de/T--Pasteur_Paris--JPHonsOlivierRecadre.jpg"> | <img src="https://static.igem.org/mediawiki/2018/d/de/T--Pasteur_Paris--JPHonsOlivierRecadre.jpg"> | ||
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− | <div class="block title"><h3 style="text-align: left;"> | + | <div class="block title"><h3 style="text-align: left;">i.CERAM </h3></div> |
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− | <p> | + | <p>i.CERAM based in Limoges, France, was founded in 2005 and is designing, manufacturing and marketing high-tech implants for various joints of the human body. The marriage of different ceramic materials and processes is one of the main features of the company. Thus, the clinical experience, combined with compressive strength qualities, osseo-compatibility or decreased friction ceramics are exploited in the design of new implants of the company. The best seller of the company is a ceramic implant charged in antibiotics. </p> |
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<h4 style="text-align: left;">Interview with Dr. Eric DENES, Dr. Evelyn Poli and Dr. Christelle Arico </h4> | <h4 style="text-align: left;">Interview with Dr. Eric DENES, Dr. Evelyn Poli and Dr. Christelle Arico </h4> | ||
− | <p><i>Dr. Eric Denes is an infectious diseases specialist at the University Hospital of Limoges and is the scientific director of | + | <p><i>Dr. Eric Denes is an infectious diseases specialist at the University Hospital of Limoges and is the scientific director of i.CERAM. Dr. Evelyn Poli is a chemistry research and development engineer and Dr. Christelle Arico is a project manager at i.CERAM. </i></p> |
</br> | </br> | ||
<p>Dr. Eric Denes, as well as Dr. Evelyn Poli and Dr. Christelle, were very interested in our project. They are currently designing new materials in ceramic, titanium, and stainless-steel to test the bacterial adhesion on their prostheses. They warned us about the use of metals for the prostheses since <i>S. aureus</i> and <i>P. aeruginosa</i> tend to form biofilms easily on metals rather than on ceramic. They are also using Gentamicin and Vancomycin charged implants to cure infections. Their system does have a long half-life time (4 days) whereas our biofilm could be a longer-term solution. </p> | <p>Dr. Eric Denes, as well as Dr. Evelyn Poli and Dr. Christelle, were very interested in our project. They are currently designing new materials in ceramic, titanium, and stainless-steel to test the bacterial adhesion on their prostheses. They warned us about the use of metals for the prostheses since <i>S. aureus</i> and <i>P. aeruginosa</i> tend to form biofilms easily on metals rather than on ceramic. They are also using Gentamicin and Vancomycin charged implants to cure infections. Their system does have a long half-life time (4 days) whereas our biofilm could be a longer-term solution. </p> |
Revision as of 14:22, 14 October 2018