Difference between revisions of "Team:Grenoble-Alpes/Model"

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<p>In order to optimize the lysis step in our system, we used a modeling of the interaction between phages and bacteria. However, the purpose of this system is also to promote therapy. With this in mind, we used our modeling to give the doctor a tool to optimize the therapy dose needed by the patient.</p><p>
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After working on this model for some time we reached out to Ruth Bentley from the Nottingham iGEM team, we were able to work together and to discuss different modeling aspects. </p><p>
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It is important to note, that even though we worked on a lot of the theory together, we implemented the model with different languages, as Ruth coded on python and our work was done in Matlab. </p><p>
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All our modeling codes can be found here <b>[download link of .zip with files]</b></p>
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<hr>
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<p>For our modelling we based ourselves on an article [1], in which the authors model the interactions between phages and bacteria using the following equations: </p>
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<figure><center><img src="https://static.igem.org/mediawiki/2018/f/f2/T--Grenoble-Alpes--modellingPic1.png"></center></figure>
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<br>
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<p>Where :</p>
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<ul><li><p>S is the number of susceptible bacteria  (the one that can be infected by phages)</p></li>
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<li><p>R is the number of mutated bacteria (the one who became resistant to phages)</p></li>
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<li><p>I is the number of infected bacteria, and therefore will be killed by the phage after a latent time</p></li>
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<li><p>V is the number of phages</p></li></ul>
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<p>The parameters are described in the table below:</p>
  
  

Revision as of 18:48, 14 October 2018

Template loop detected: Template:Grenoble-Alpes

MODELING

In order to optimize the lysis step in our system, we used a modeling of the interaction between phages and bacteria. However, the purpose of this system is also to promote therapy. With this in mind, we used our modeling to give the doctor a tool to optimize the therapy dose needed by the patient.

After working on this model for some time we reached out to Ruth Bentley from the Nottingham iGEM team, we were able to work together and to discuss different modeling aspects.

It is important to note, that even though we worked on a lot of the theory together, we implemented the model with different languages, as Ruth coded on python and our work was done in Matlab.

All our modeling codes can be found here [download link of .zip with files]



For our modelling we based ourselves on an article [1], in which the authors model the interactions between phages and bacteria using the following equations:



Where :

  • S is the number of susceptible bacteria (the one that can be infected by phages)

  • R is the number of mutated bacteria (the one who became resistant to phages)

  • I is the number of infected bacteria, and therefore will be killed by the phage after a latent time

  • V is the number of phages

The parameters are described in the table below: