Difference between revisions of "Team:Jilin China"

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   <h1>ABSTRACT</h1>
 
   <h1>ABSTRACT</h1>
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   <p>Many strategies could be used by bacteria to coordinate temperature-dependent gene expression. A well-known class of biological thermoregulatory element is RNA-based thermosensor (RT), which is located in the 5'-untranslated region of mRNA. RTs could sense temperature change and influence the mRNA degradation or ribosome accessibility, thereby controlling translation efficiency.</p>
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   <p>Many strategies could be used to regulate the gene expression responding to temperature changes. A well-known class of biological thermoregulatory element are RNA-based thermosensors (RTs), which are located in the 5'-untranslated region of mRNA. RTs could sense temperature shift and influence the mRNA stability or ribosome accessibility, thereby controlling translation efficiency.</p>
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   <p>However, natural RNA-based thermosensors have complex structure and narrow sensing temperature range, which become the biggest limitation on their prospective application. To address this issue, we created synthetic RNA-based thermosensors (SynRTs) toolkit responding to different sensing temperatures and different intensits. Futhermore, we built a matched search engine for potential users.
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   <p>However, natural RNA-based thermosensors have complex structure and narrow sensing temperature range, which become the biggest limitation in their prospective application. To address this issue, we created a synthetic RNA-based thermosensors (SynRTs) toolkit with different sensing temperatures and different intensities. Futhermore, we built a matched search engine for potential users.
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   <p>The SynRT toolkit have updated from version 1.0 to 3.0, and the newest version is composed of four types of SynRTs:</p>
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   <p>The SynRT toolkit version has been updated from 1.0 to 3.0, and the newest version is composed of four types of SynRTs:</p>
 
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Revision as of 11:19, 17 October 2018

The Collection of
SynRT
with Different Sensing Temperatures

ABSTRACT

Many strategies could be used to regulate the gene expression responding to temperature changes. A well-known class of biological thermoregulatory element are RNA-based thermosensors (RTs), which are located in the 5'-untranslated region of mRNA. RTs could sense temperature shift and influence the mRNA stability or ribosome accessibility, thereby controlling translation efficiency.

However, natural RNA-based thermosensors have complex structure and narrow sensing temperature range, which become the biggest limitation in their prospective application. To address this issue, we created a synthetic RNA-based thermosensors (SynRTs) toolkit with different sensing temperatures and different intensities. Futhermore, we built a matched search engine for potential users.

The SynRT toolkit version has been updated from 1.0 to 3.0, and the newest version is composed of four types of SynRTs:

SD Sequence anti-SD Sequence Ribosome

Hot-induced 5'UTR

RC anti-RC RNAse E
Stroke Version_1 RC RNAse III

Human Practices

Model

More

Title