Difference between revisions of "Team:Jilin China/Human Practices"

 
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       <h2>INTRODUCTION</h2>
 
       <h2>INTRODUCTION</h2>
−
       <p>With the initial interest of learning the relationship between RNA-structure and gene expression intensity under different temperatures, our project this year has participated in the basic research study. Actually, a laboratorial achievement should go through a long way to apply into various kinds of fields. There are many issues should be considered during the long-term scientific transformation process. After the tour of fermentation factory, we were aware of those considerations as well. A research of views about current investment and transformation situation in China guided our further HP activities. Ultimately, we took eyes into developing our collection as <a href="/Team:Jilin_China/HP/Supplementary">a Scientific Tool</a> and create <a href="/Team:Jilin_China/HP/Supplementary">a Decades Work Flow</a>.</p>
+
       <p>With the initial interest of learning the relationship between RNA-structure and gene expression intensity under different temperatures, our project this year has participated in the basic research study. Actually, a laboratorial achievement should go through a long way to apply into various kinds of fields. There are many issues should be considered during the long-term scientific transformation process. After the tour of fermentation factory, we were aware of those considerations as well. A research of views about current investment and transformation situation in China guided our further HP activities. Ultimately, we took eyes into developing our collection as <a href="/Team:Jilin_China/HP/3">a Scientific Tool</a> and create <a href="/Team:Jilin_China/HP/5">a Decade Work Flow</a>.</p>
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       <h2>1. TOUR OF THE DIARY FACTORY</h2>
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       <h2>1. TOUR TO INDUSTRY</h2>
−
       <p>Hoping to know who our potential users is, we did some research and consulted relevant teachers about how temperature regulation is applied in industry and manufacture.</p>
+
       <p>From the beginning of our Human Practices, we would like to find some potential users. Because temperature is essential in industry, we took our eyes on temperature regulation in different fields of manufacture. We asked some of the teachers and relevant staff, and got a series of temperatures of many different types of  products. Then we found out that our toolkit may fit to yogurt fermentation, so we went to Ground Diary for further research. </p>
−
       <p>Here, according to our research, a form illustrating production and required temperature is shown.</p>
+
       <p>The technists there suggested us to focus on the <a href="https://2018.igem.org/Team:Jilin_China/Project/Overview#HP">intensity and sensitivity</a>, not just temperature, while they were satisfied with temperature sensing range we set. Interestingly, they said that our thermosensors can help conserve energy and bring economic benefit if we can lower down the fermentation temperature.</p>
−
      <img src="https://static.igem.org/mediawiki/2018/2/21/T--Jilin_China--Practices--P1--Various_Temp.svg" width="100%"/>
+
       <p><b>Based on the suggestions, we improved our initial Toolkit to</b> <a href="https://2018.igem.org/Team:Jilin_China/Result/Version_1">SynRT Toolkit 1.0</a>.</p>
−
      <p>On the basis of the first batch of <a>statistics: RNA thermosensors response to temperature at around 37-42°C</a>, our thermosensors may fit to need of yogurt production. Then we visited the Ground Dairy Industry Co.,Ltd, the biggest local diary products supplier in Changchun.</p>
+
       <p><a href="https://2018.igem.org/Team:Jilin_China/HP/1">Learn More></a></p>
−
       <p>After visiting the manufacturing shop and interviewing the technical staff, we realized the sensing section of RNA thermosensors we set before is quite fit to the product requirement. However，they’re not quite satisfied with the intensity and sensitivity of our thermosensors. Then we decided to make continuous intensity intervals and sensitivity for users. With the help of Model team, our toolkit was improved into SynRT toolkit 1.0. (link)</p>
+
 
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      <div class="additional">
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      <h3>Bonus Track</h3>
+
−
      <p>Our initial idea of this tour is to find an output of our toolkit, and we did find out that our kit could be useful in future fermentation process. However, to our surprise, the technicist there also told us, ‘ If you can lower down the temperature of initial fermentation, it would bring huge economic profits.’ From the point of view, we believed that our toolkit can realize this temperature shift.</p>
+
−
      <p>Compared with our Positive Control, which turns into open conformation at around 42°C, some of thermosensors in our toolkit can realized the same purpose at lower temperature. The data has been shown below.</p>
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       <h2>2. CURRENT SITUATION & PUBLIC VIEWS OF TRANSFORMATION</h2>
 
       <h2>2. CURRENT SITUATION & PUBLIC VIEWS OF TRANSFORMATION</h2>
−
       <p>On the basis of our research in industry, we’ve realized that there’re truly some problems in transformation today. </p>
+
       <p>On the basis of our research in industry, we have realized that there are truly some problems in transformation these days. </p>
−
       <p>Moving forward to learn about technology transformation situations in data and public views, we read Statistical Yearbook of Science and Technology of China and Do A Questionnaire to get guidance. After that, we made a research report to analyze and summarize the results. </p>
+
       <p>To learn about technology transformation situations in data and public views, we read <b>Statistical Yearbook of Science and Technology of China</b> and <a href="https://2018.igem.org/Team:Jilin_China/HP/Supplementary#Questionnaire">Do A Questionnaire</a>. After that, we made a research report to analyze and summarize the results. </p>
−
       <p>In summary, we decided to turn our focus into finding medical output while visiting relevant institutions. Also, we need to know more about investment situations due to the results from Yearbook and the Questionnaire.</p>
+
       <p>In summary, we decided to turn our focus on finding medical output while visiting relevant institutions. Also, we need to have a better understanding of investment situations due to the results from Yearbook and Questionnaire.</p>
−
       <p><a>Learn More></a></p>
+
       <p><a href="https://2018.igem.org/Team:Jilin_China/HP/2">Learn More></a></p>
 
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       <h2>3. TOOLKIT DEVELOPMENT</h2>
 
       <h2>3. TOOLKIT DEVELOPMENT</h2>
−
       <p>Due to the results of our previous research, we decided to turn our focus on medicine output of our toolkit. After visiting Institute of Translational Medicine in Jilin University and Changchun BCHT Biotechnology Company, we knew that it could take a long time for a foundational project to apply into clinical research. Also, according to what Prof. Jiang in BCHT said, controlling low temperature in pharmacy is a essential factor, we decided to perfect our toolkit into a more stable and multi-functional tookit. Then Toolkit 2.0 and Toolkit 3.0 were born! As our potential users in current stage, some researchers joined in our toolkit evaluation. According to their suggestions, we designed an expression vector.</p>
+
       <p>Due to the results of our previous research, we decided to turn our focus on medicine output of our toolkit. After visiting Institute of Translational Medicine in Jilin University and Changchun BCHT Biotechnology Company, we knew that it could take a long time for a foundational project to apply into clinical research. Also, according to what Prof. Jiang in BCHT said, <b>controlling low temperature in pharmacy is a essential factor, we decided to perfect our toolkit</b> into a more stable and multi-functional tookit. Then <a href="https://2018.igem.org/Team:Jilin_China/Result/Version_2">Toolkit 2.0</a> and <a href="https://2018.igem.org/Team:Jilin_China/Result/Version_3">Toolkit 3.0</a> were born! As our potential users in current stage, some researchers joined in our toolkit evaluation. According to their suggestions, we designed an expression <a href="https://2018.igem.org/Team:Jilin_China/HP/Supplementary#vector">vector.</p>
−
       <p><a>Learn More></a></p>
+
       <p><a href="https://2018.igem.org/Team:Jilin_China/HP/3">Learn More></a></p>
 
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       <h2>4. MORE EXPLORATION</h2>
 
       <h2>4. MORE EXPLORATION</h2>
 
       <p>To complete our investigation, we put more efforts in exploring the current situations from more specific views. We asked the questions about transformation issues with Nobel Prize Winners, Hartmut Michel and Dan Shechtman, Dean of College of Life Sciences, Prof. Yu Xianghui and Mr Zhao Lu, CEO from TAIMEI TECH. </p>
 
       <p>To complete our investigation, we put more efforts in exploring the current situations from more specific views. We asked the questions about transformation issues with Nobel Prize Winners, Hartmut Michel and Dan Shechtman, Dean of College of Life Sciences, Prof. Yu Xianghui and Mr Zhao Lu, CEO from TAIMEI TECH. </p>
−
       <p>The Nobel Prize Winners focus more on the research itself while they believe that applications also should be considered when there’s a new discovery. For investment, Prof. Yu, she told us that the government is the largest department to give finical support to research, however, they refuse venture capital most of time. And Mr Zhao, as an entrepreneur, thinks that potential market value is the most important when a company choose to support a basic or applied research. Fortunately, Mr Zhao showed great interest in our project, so this year, he decided to be our sponsor this year hoping our Toolkit can realize potential value in medicine someday. </p>
+
       <p>The Nobel Prize Winners focus more on the research itself while they believe that applications also should be considered when there’s a new discovery. For investment, Prof. Yu, she told us that the government is the largest department to give finical support to research, however, they refuse venture capital most of time. And Mr Zhao, as an entrepreneur, thinks that potential market value is the most important when a company choose to support a basic or applied research. Fortunately, Mr Zhao showed great interest in our project, so this year, he decided to be our sponsor this year hoping our SynRT Toolkit can realize potential value in medicine someday. </p>
 
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       <h2>5. DECADE WORKFLOW</h2>
 
       <h2>5. DECADE WORKFLOW</h2>
−
       <p>As a foundational RNA-based temperature sensor toolkit, we have tried our best to find some potential users and relevant output. Our toolkit would be applied in some fields in the future potentially. However, there’re still too much to be considered if we want the toolkit widely used and marketized. It is a good vision for us to build a Decades Work Flow to make plan for our future work and perfect the toolkit while benefiting the world. From a recent view, we hope that the Decades Work Flow can inspire the other iGEM teams in the long-term scientific research.</p>
+
       <p>As a foundational RNA-based temperature sensor toolkit, we have tried our best to find some potential users and relevant output. Our toolkit would be applied in some fields in the future potentially. However, there are still too much to be considered if we want SynRT Toolkit widely used and marketed. It is a good vision for us to build a Decade Work Flow to make plan for our future work and perfect the SynRT Toolkit while benefiting the world. From a recent view, <b>we hope that the Decade Work Flow can inspire the other iGEM teams in the long-term scientific research</b>.</p>
 +
      <p><a href="https://2018.igem.org/Team:Jilin_China/HP/5">Learn More></a></p>
 
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Latest revision as of 12:07, 17 October 2018

INTEGRATE OUR
PRACTICES


Human Practices

  • INTRODUCTION

    With the initial interest of learning the relationship between RNA-structure and gene expression intensity under different temperatures, our project this year has participated in the basic research study. Actually, a laboratorial achievement should go through a long way to apply into various kinds of fields. There are many issues should be considered during the long-term scientific transformation process. After the tour of fermentation factory, we were aware of those considerations as well. A research of views about current investment and transformation situation in China guided our further HP activities. Ultimately, we took eyes into developing our collection as a Scientific Tool and create a Decade Work Flow.

SEE OUR JOURNEY

  • 1. TOUR TO INDUSTRY

    From the beginning of our Human Practices, we would like to find some potential users. Because temperature is essential in industry, we took our eyes on temperature regulation in different fields of manufacture. We asked some of the teachers and relevant staff, and got a series of temperatures of many different types of products. Then we found out that our toolkit may fit to yogurt fermentation, so we went to Ground Diary for further research.

    The technists there suggested us to focus on the intensity and sensitivity, not just temperature, while they were satisfied with temperature sensing range we set. Interestingly, they said that our thermosensors can help conserve energy and bring economic benefit if we can lower down the fermentation temperature.

    Based on the suggestions, we improved our initial Toolkit to SynRT Toolkit 1.0.

    Learn More>


  • 2. CURRENT SITUATION & PUBLIC VIEWS OF TRANSFORMATION

    On the basis of our research in industry, we have realized that there are truly some problems in transformation these days.

    To learn about technology transformation situations in data and public views, we read Statistical Yearbook of Science and Technology of China and Do A Questionnaire. After that, we made a research report to analyze and summarize the results.

    In summary, we decided to turn our focus on finding medical output while visiting relevant institutions. Also, we need to have a better understanding of investment situations due to the results from Yearbook and Questionnaire.

    Learn More>


  • 3. TOOLKIT DEVELOPMENT

    Due to the results of our previous research, we decided to turn our focus on medicine output of our toolkit. After visiting Institute of Translational Medicine in Jilin University and Changchun BCHT Biotechnology Company, we knew that it could take a long time for a foundational project to apply into clinical research. Also, according to what Prof. Jiang in BCHT said, controlling low temperature in pharmacy is a essential factor, we decided to perfect our toolkit into a more stable and multi-functional tookit. Then Toolkit 2.0 and Toolkit 3.0 were born! As our potential users in current stage, some researchers joined in our toolkit evaluation. According to their suggestions, we designed an expression vector.

    Learn More>


  • 4. MORE EXPLORATION

    To complete our investigation, we put more efforts in exploring the current situations from more specific views. We asked the questions about transformation issues with Nobel Prize Winners, Hartmut Michel and Dan Shechtman, Dean of College of Life Sciences, Prof. Yu Xianghui and Mr Zhao Lu, CEO from TAIMEI TECH.

    The Nobel Prize Winners focus more on the research itself while they believe that applications also should be considered when there’s a new discovery. For investment, Prof. Yu, she told us that the government is the largest department to give finical support to research, however, they refuse venture capital most of time. And Mr Zhao, as an entrepreneur, thinks that potential market value is the most important when a company choose to support a basic or applied research. Fortunately, Mr Zhao showed great interest in our project, so this year, he decided to be our sponsor this year hoping our SynRT Toolkit can realize potential value in medicine someday.


  • 5. DECADE WORKFLOW

    As a foundational RNA-based temperature sensor toolkit, we have tried our best to find some potential users and relevant output. Our toolkit would be applied in some fields in the future potentially. However, there are still too much to be considered if we want SynRT Toolkit widely used and marketed. It is a good vision for us to build a Decade Work Flow to make plan for our future work and perfect the SynRT Toolkit while benefiting the world. From a recent view, we hope that the Decade Work Flow can inspire the other iGEM teams in the long-term scientific research.

    Learn More>