Difference between revisions of "Team:Pasteur Paris/TrainingThomas4"

 
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        <p>In science fiction movies, some amputees are equipped with incredibly efficient bionic prostheses that enable them to accomplish everyday gestures as any valid person would. Presently, the very best equipment that can be offered to amputees is still far from meeting their expectations or those seen in the movies</p>
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<p><i>This year iGEM Pasteur Paris attended multiple events with the purpose of spreading information about what iGEM is, inside and outside scientific fields. We decided not to limit ourselves to the Parisian region, so we travelled all around France and even to Denmark talking about our project NeuronArch. Our talks were not only with biologists but with physicists, mathematicians, chemists. We wanted also to speak with middle and high school students and even children, trying to vulgarize our project, synthetic biology and science in order to spark vocations.  </i></p>
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<div class="block title"><h1>Engaging the Scientific Community</h1></div>
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<p>The Translational Research Day is a full day mini symposium dedicated to translational research. The event was organized at Institut Pasteur (Paris) from 2007 by the former Center for Human Immunology. Since 2015, it is organized by the Translational Research Center. This year, it focuses on gathering scientists working on neuropsychology, microbiota and angering. We had the pleasure to share our ideas and present to the scientific world for the first time our team’s projet NeuronArch through our first poster. </p>
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        <p>We decided to create a universal biological interface that would be able to connect the residual nerves from the amputees’ limbs to the prostheses. We show up with the creation of a Biofilm coated on the implants. Bacteria secreting neurotrophins (e.g. proNGF) from the interface to help the nerves grow back towards the prothesis.</p>
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        <p style="text-align: center; text-indent: 0;"><i><b>With this innovation came the necessity to have the device surgically osseointegrated to the patient</b></i></p>
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<p>The Young Researchers in Life Sciences (YRLS) is one of the most important spring conference. We participated in the 9<sup>th</sup> edition conference held from the May 2<sup>nd</sup> -4<sup>th</sup> at Ecole Normale Supérieure, Paris. Young researchers presented their projects through a scientific poster, like we did, and gave us some precious advices on the experiments to come.</p>
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        <p>This opened our minds to a huge challenge with orthopedic implants: infectious biofilms. They frequently develop around implants and cause heavy infections, very resistant to antibiotics. Our strategy concentrate efforts on fighting against <i>S. aureus</i>, by disturbing the quorum sensing. This mechanism regulates and coordinates the biofilm’s architecture and the production of toxins and virulence factors. </p>
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<p>Viva Technology is a commercial fair dedicated to technological innovations in Paris. On may 24th, we attended the “welcome to the bionic age” conference hosted by David Aguilar Amphoux, Moran Cerf, and Ernesto Martinez Villalpando. During one hour, they spoke about bionic prosthesis and how do we make, use and connect them directly to the human brain. </p>
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<h3 style="text-align: left;">Biofilms 8 </h3>
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        <p style="text-align: center; text-indent: 0;"><i><b>We decided to tackle both problems at the same time, using synthetic biology to add a barrier of protection against pathogenic bacteria directly into our device.</i></b></p>
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<p>Members of our team flew to Denmark to attend Biofilms 8 conference held in May 27-29 in Aarhus University. The conference gathered experts from all around the world in the field of bacterial communities and biofilm way of life. We presented our poster during poster sessions to biologists, doctors and engineers. This conference allowed us to further exchange with Françoise Van Bambeke, Doctor in Pharmaceutical Science in the University of Louvain, Belgium, who has been working for years on the pharmacological fight against biofilm. Exchanging with her confirmed us that acting on Quorum sensing to avoid biofilm formation could be an efficient approach, and she advised us to try to investigate on the advantages of our synthetic biology approach compared to classic pharmacologic solutions. </p>
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        <p>We designed this interface as something that could become the new standard, something that would then be connected to any bionic prosthesis, and that would allow a much greater control of movement. We mixed synthetic biology with disciplines like physics and industrial design to come up with the following prototype. </p>
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        <p style="text-align: center; text-indent: 0;">Since we began working on NeuronArch, we have all endeavored to make it become something real.</br> We hope you will have as much fun discovering our project through our wiki as we had making it.</p>
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Latest revision as of 13:36, 17 October 2018

""

In science fiction movies, some amputees are equipped with incredibly efficient bionic prostheses that enable them to accomplish everyday gestures as any valid person would. Presently, the very best equipment that can be offered to amputees is still far from meeting their expectations or those seen in the movies

We decided to create a universal biological interface that would be able to connect the residual nerves from the amputees’ limbs to the prostheses. We show up with the creation of a Biofilm coated on the implants. Bacteria secreting neurotrophins (e.g. proNGF) from the interface to help the nerves grow back towards the prothesis.

With this innovation came the necessity to have the device surgically osseointegrated to the patient

This opened our minds to a huge challenge with orthopedic implants: infectious biofilms. They frequently develop around implants and cause heavy infections, very resistant to antibiotics. Our strategy concentrate efforts on fighting against S. aureus, by disturbing the quorum sensing. This mechanism regulates and coordinates the biofilm’s architecture and the production of toxins and virulence factors.

We decided to tackle both problems at the same time, using synthetic biology to add a barrier of protection against pathogenic bacteria directly into our device.

We designed this interface as something that could become the new standard, something that would then be connected to any bionic prosthesis, and that would allow a much greater control of movement. We mixed synthetic biology with disciplines like physics and industrial design to come up with the following prototype.

Since we began working on NeuronArch, we have all endeavored to make it become something real.
We hope you will have as much fun discovering our project through our wiki as we had making it.