Difference between revisions of "Team:VIT Vellore"
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<h1> Welcome to iGEM 2018! </h1> | <h1> Welcome to iGEM 2018! </h1> | ||
<p>Your team has been approved and you are ready to start the iGEM season! </p> | <p>Your team has been approved and you are ready to start the iGEM season! </p> | ||
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| + | <h3>About our project</h3> | ||
| + | <p>Overall increase in industrialization has led to an overall increase in the carbon footprint, the major component being CO<sub>2</sub> which led to global warming, among other ill effects of industrialization, the one that has gained a lot of attraction is what we call as<b> Ocean Acidification </b> also known as "the other CO<sub>2</sub> problem" and that's where our engineered microbe jumps in.</p> | ||
| + | <p>Geology reports suggest that between 1751 to 1996 there has been an increase of H<sup>+</sup> ions of upto 30% apart from that the overall pH has been decreased from 8.25 to 8.14. Increasing acidity is directly linked to being having potentially harmful consequences for marine organisms, such as depressing metabolic rates and immune responses in some organisms, and causing in worst cases coral bleaching</p> | ||
| − | + | <p> "If we continue emitting CO2 at the same rate, by 2100 ocean acidity will increase by about 150 percent, a rate that has not been experienced for at least 400,000 years."</p> | |
| − | + | <p>-United Kingdom Ocean Acidification Research Programme, 2015</p> | |
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| + | <p>Our engineered vibrio will interact with it’s surrounding environment to give real-time H<sub>+</sub> data which is then used by a pH-sensitive NhaA and CadA promoters which give maximum expression at pH 8.5 and pH 7 respectfully after which the expression is downregulated. With this 1.5 pH window our biobricks are designed so that the carbonic anhydrase genes that bring about a reduction in ocean acidification, once the pH is stabilized, repressor proteins are expressed which block the carbonic anhydrase expression so that no more shuttle of H<sup>+</sup> thereby saving marine flora and fauna from any damage</p> | ||
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Revision as of 23:15, 29 June 2018
Where would you like to go?
Welcome to iGEM 2018!
Your team has been approved and you are ready to start the iGEM season!
About our project
Overall increase in industrialization has led to an overall increase in the carbon footprint, the major component being CO2 which led to global warming, among other ill effects of industrialization, the one that has gained a lot of attraction is what we call as Ocean Acidification also known as "the other CO2 problem" and that's where our engineered microbe jumps in.
Geology reports suggest that between 1751 to 1996 there has been an increase of H+ ions of upto 30% apart from that the overall pH has been decreased from 8.25 to 8.14. Increasing acidity is directly linked to being having potentially harmful consequences for marine organisms, such as depressing metabolic rates and immune responses in some organisms, and causing in worst cases coral bleaching
"If we continue emitting CO2 at the same rate, by 2100 ocean acidity will increase by about 150 percent, a rate that has not been experienced for at least 400,000 years."
-United Kingdom Ocean Acidification Research Programme, 2015
Our engineered vibrio will interact with it’s surrounding environment to give real-time H+ data which is then used by a pH-sensitive NhaA and CadA promoters which give maximum expression at pH 8.5 and pH 7 respectfully after which the expression is downregulated. With this 1.5 pH window our biobricks are designed so that the carbonic anhydrase genes that bring about a reduction in ocean acidification, once the pH is stabilized, repressor proteins are expressed which block the carbonic anhydrase expression so that no more shuttle of H+ thereby saving marine flora and fauna from any damage