Difference between revisions of "Team:Jilin China"
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<img src="https://static.igem.org/mediawiki/2018/e/e1/T--Jilin_China--Home--HP--1.svg" /> | <img src="https://static.igem.org/mediawiki/2018/e/e1/T--Jilin_China--Home--HP--1.svg" /> | ||
<a href="https://2018.igem.org/Team:Jilin_China/Public_Engagement">Hear Our Stories</a> | <a href="https://2018.igem.org/Team:Jilin_China/Public_Engagement">Hear Our Stories</a> | ||
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<p>Several Innovative Kits</p> | <p>Several Innovative Kits</p> | ||
Revision as of 21:53, 17 October 2018
ABSTRACT
Many strategies could be used to regulate the gene expression responding to temperature changes in bacterial cells. A well-known class of biological thermoregulatory elements includes RNA-based thermosensors (RTs), which are located in the 5'- untranslated region in mRNA. RTs could sense temperature shift and influence the mRNA stability or ribosome accessibility, thereby controlling translation efficiency.
However, natural RNA-based thermosensors have complex structure and narrow sensing temperature range, which become the biggest limitation in their application. To address this issue, we have created a synthetic RNA-based thermosensor (SynRT) toolkit with different sensing temperatures. Additionally, we built a matched search engine for users.
The SynRT toolkit version has been updated from 1.0 to 3.0, and the latest version is composed of four types of SynRTs:
Hot-induced 5'UTR
Human Practices
Several Exploration Improved
OUR TOOLKITs
meanwhile Inspiring Us to Make
A DECADE
WORKFLOW
Hear Our Stories
Several Innovative Kits
Promoting Us to
SPREAD and DISCUSS
Synthetic Biology
Hear Our Stories
Model
More
Title