Difference between revisions of "Team:Sorbonne U Paris/Collaborations"

 
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<div class="container">  <article class="col-md-10"><h1> Our collaborations</h1>
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<p class="introduction-text">The availability of new technologies has facilitated the exchanges worldwide and so promoted multidisciplinarity and collaboration in science. Collaboration is a key part among iGEMers. Indeed, collaborations help to achieve goals that would not be fulfilled alone. This year the Sorbonne U Paris 2018 team has been collaborating with 9 iGEM teams from all over the world. Herein, we detail the nature of all of our collaborations with these awesome teams with whom we shared great moments for which thank them a lot! <br> <br>By clicking on our collaborators' logos, you will have access to the abstract of their project.</p></article></div>
  
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<li class="list-group-item"><a class="pointer"href="#5">iGEM Duesseldorf</a></li>
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<li class="list-group-item"><a class="pointer"href="#2">iGEM Pasteur </a></li>
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                                            <h2 id="1" class="title-h2">iGEM Go Paris Saclay</h2>
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                                        <h2 style="color: #891570; padding-bottom: 20px;">iGEM Go Paris Saclay</h2>
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                                        <h4 style="color: #891570">MethotrExit: a HeteroGenious Cleaning Factory</h4>
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<p>Cytotoxic anticancer drugs are among the harmful chemicals found in hospital wastewater at high concentrations. Degradation processes through physical and chemical methods exist but are often inefficient, unsustainable or expensive. We propose MethotrExit, a bioreactor-based approach to tackle this problem. We focused on the biotransformation of methotrexate (MTX), a widely used anticancer drug. We designed synthetic cassettes encoding a new biotransformation pathway using a heterologous carboxypeptidase in Escherichia coli. In only five hours, MethotrExit drastically removes MTX from the media. However, anticancer drug degradation products and/or the biotransformation pathway itself might be toxic for E. coli. To overcome this issue, biobricks generating heterogeneity in enzyme expression were built to ensure survival of a subpopulation. Modelling of this system highlights the interest of a division of labor between “cleaning” and “stem” bacterial cells.</p>
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<a class="pointer" href="https://2018.igem.org/Team:GO_Paris-Saclay" id="teampagelink" style="color: #DC8CC3"> https://2018.igem.org/Team:GO_Paris-Saclay</a>
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      <p>The iGEM Go Paris Saclay team and us have built a very strong relationship and have faced various challenges together. Their mathematicians introduced us to the bio-modeling bases. We could implement our essential retrotransposons' biological data into the model created together. Indeed, this model aimed to simulate the behavior of our retrotransposons. So, we are able to generate a data bank to select the best parts for our system. <br> <br>
  
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For more information about our modelling visit our modelling page.
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On our side, Céline, our former wiki manager, taught some members of the iGEM Paris Saclay team to code, in order to realize their wiki page and Saniya has been an advisor.<br><br>
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                                        NAVIGATION
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Marie-Charlotte realized several sketches of their logo for a submission to a design agency. <br><br>
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They also took part in the organization of the conference untitled  “What will synthetic biology bring to the future?” hosted on the Campus Pierre et Marie Curie of Sorbonne Université. They helped us contact experts and purchase food and materials for the buffet through a communal fund.
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<p>Further information about this conference are available on the Human practices pages section “Public engagement and education”.
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<img  src="https://static.igem.org/mediawiki/2018/5/5e/T--Sorbonne_U_Paris--Saclay1.JPG"alt="Meeting with The iGEM Saclay team for modelling" style="width: 100%">
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    <figcaption style="padding: 10px;"><b>Figure 1: </b> Meeting with The Paris Saclay Team for modelling <br> From left to right : Raphaël GUEGAN, Kenn PAPADOPOULO, Guillaume GARNIER, Ousmane DAO, Victor SAYOUS and Céline MORIN </figcaption>
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<!-- -----------------------------------SECTIION : iGEM BORDEAUX--------------------------------------------------------- -->
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  *                              DO NOT EDIT FROM THIS POINT!                                          *
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        <article class="col-md-10 collaboration">
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                  <!-- ---------------------MODAL : iGEM Bordeaux ----------------------------------------------------->
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                                            <h2 id="4" class="title-h2">iGEM  Bordeaux</h2>
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<h4 style="color:#02A9D5">Abtract</h4>
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<p>This year IGEM Bordeaux Team would like to find an alternative to an entire segment of the traditional petrobased chemistry by a new green biobased chemistry. Indeed, we would like to focus on the biocatalysis of the hydroxymethylfurfural (HMF) in 2,5-furandicarboxylic acid (FDCA). Don’t worry, it is not as complicated as it appears. HMF is a by-product of the lignocellulosic biomass treatment. Its toxicity toward microorganisms leads to big issue for many companies which want to use these microorganisms to produce molecules of interest from lignocellulosic biomass. Our project consists in HMF detoxification by using it as a substrate to produce FDCA through bacteria .FDCA was identify as one of most promising biobased molecules which can replace many polymers such as PET (and other petrobased molecules). We suggest a sustainable alternative, eco-friendly and independent from fossil resource.
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<a class="pointer" href="https://2018.igem.org/Team:Bordeaux" id="teampagelink" style="color: #02A9D5"> https://2018.igem.org/Team:Bordeaux</a>
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<!-- ------------------------------------------MODAL : IGEM BORDEAUX ----------------------------------------------------->
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<!-- -------------------------------------TEXT: iGEM BORDEAUX----------------------------------------------------->
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          <p>“Friendship is born at that moment when one person says to another: “What! You too? I thought I was the only one.” (C.S Lewis). It is the perfect quote to sum up our collaboration with the iGEM Bordeaux team. We first met at the Parisian meetup in Paris (7th July 2018). As we share the same conception of an iGEM project, our partnership was obvious. 
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We invited them to participate to the organization of the conference “What will synthetic biology bring to the future?”. They helped us a lot to contact experts.</p>
  
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.cssmap-250 .eu1 a{left:132px;top:172px}.cssmap-250 .eu1 a.tooltip-right .tooltip-arrow{right:118px} .cssmap-250 .eu2 a{left:79px;top:167px}.cssmap-250 .eu2 a.tooltip-left .tooltip-arrow{left:79px} .cssmap-250 .eu3 a{left:117px;top:146px}.cssmap-250 .eu3 a.tooltip-left .tooltip-arrow{left:117px} .cssmap-250 .eu4 a{left:155px;top:119px}.cssmap-250 .eu4 a.tooltip-right .tooltip-arrow{right:95px} .cssmap-250 .eu5 a{left:88px;top:133px}.cssmap-250 .eu5 a.tooltip-left .tooltip-arrow{left:88px} .cssmap-250 .eu6 a{left:126px;top:161px}.cssmap-250 .eu6 a.tooltip-left .tooltip-arrow{left:126px} .cssmap-250 .eu7 a{left:147px;top:167px}.cssmap-250 .eu7 a.tooltip-right .tooltip-arrow{right:103px} .cssmap-250 .eu8 a{left:122px;top:154px}.cssmap-250 .eu8 a.tooltip-left .tooltip-arrow{left:122px} .cssmap-250 .eu9 a{left:170px;top:195px}.cssmap-250 .eu9 a.tooltip-right .tooltip-arrow{right:80px} .cssmap-250 .eu10 a{left:119px;top:137px}.cssmap-250 .eu10 a.tooltip-left .tooltip-arrow{left:119px} 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/* size: 320 */
+
<!-- -------------------------------------TEXT: iGEM Bordeaux----------------------------------------------------->
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.cssmap-320{width:320px} .cssmap-320 .europe,.cssmap-320 .europe .bg,.cssmap-320 .europe-cities{background:transparent url('https://static.igem.org/mediawiki/2018/1/15/T--Sorbonne_U_Paris--eu-320.png') no-repeat 0 0} .cssmap-320 .europe.cssmap-blue,.cssmap-320 .europe.cssmap-blue .bg,.cssmap-320 .europe-cities.cssmap-blue{background-image:url('blue/eu-320.png')} .cssmap-320 .europe.cssmap-dark,.cssmap-320 .europe.cssmap-dark .bg,.cssmap-320 .europe-cities.cssmap-dark{background-image:url('dark/eu-320.png')} .cssmap-320 .europe.cssmap-vintage,.cssmap-320 .europe.cssmap-vintage .bg,.cssmap-320 .europe-cities.cssmap-vintage{background-image:url('vintage/eu-320.png')} .cssmap-320 .europe.cssmap-custom,.cssmap-320 .europe.cssmap-custom .bg,.cssmap-320 .europe-cities.cssmap-custom{background-image:url('custom/eu-320.png')} .cssmap-320 .europe,.cssmap-320 .europe-cities{height:260px;width:320px} .cssmap-320 .europe-cities{background-position:-350px 0} .cssmap-320 .europe .m{margin:9998px 0 0 1px} .cssmap-320 .europe .m span{font-size:20px !important}
+
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<img  src="https://static.igem.org/mediawiki/2018/e/e8/T--Sorbonne_U_Paris--Affiche_conference.jpg"alt="Poster of Conference" style="width: 100%">
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    <figcaption style="padding: 10px;"><b>Figure 2: </b> Poster of the conference intitled "What will synthetic biology bring to the future?" (26th September 2018) </figcaption>
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  </figure>  </div>
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        </article>
  
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/* size: 540 */
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<!-- ----------------------------------------------------------------------------------------------------------------- -->
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+
<!-- ---------------------------------------MODAL: iGEM Newcastle ----------------------------------------------------->
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+
<div class="col-md-12 col-sm-12">
 +
<div class="box- box-color box-icon box-icon-center box-icon-round box-icon-large text-center pointer" data-toggle="modal" data-target="#TeamNewcastleModal"  title="Do you want more information about their project ? Clic !" style = "margin:0px 0px 30px 0px !important;">
 +
<div class="front">
 +
<div class="box1 box-default">
 +
<div class="box-icon-title" style = "padding-bottom: 10px !important;">
 +
                                            <h2 id="3" class="title-h2">iGEM Newcastle</h2>
 +
<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/6/67/T--Sorbonne_U_Paris--Logo_IGEMNewcastle.png"  style="width: 200px"/>
 +
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 +
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 +
</div>
 +
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 +
</div>
 +
 +
<div id="TeamNewcastleModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
 +
<div class="modal-dialog modal-lg">
 +
<div class="modal-content">
 +
                                <div class="container-fluid" style="background: black"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
 +
                            <span aria-hidden="true" >&times;</span>
 +
                                </button></div>
 +
                                                           
 +
                                   
 +
                                    <!-- Modal Header -->
 +
<div class="modal-header" >
 +
<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/6/67/T--Sorbonne_U_Paris--Logo_IGEMNewcastle.png"/>
 +
                                        <h2 style="color: black; padding-bottom: 20px;">iGEM Newcastle</h2>
 +
                                        <h4 style="color: black">Alternative Roots: Engineering Microbial Communities</h4>
 +
</div>
  
−
/* size: 850 */
+
<!-- Modal Body -->
−
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<h4 style="color:black">Abtract</h4>
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<p>The demand for food, fuel and materials is placing unprecedented pressure on agricultural production. To secure higher productivity, the sector relies upon synthetic fertilisers derived from energy intensive manufacturing methods. Here, we propose an alternative approach to support plant productivity. The Alternative Roots project investigated Pseudomonas fluorescens as a chassis organism. Development of a plant-colonising chassis provides novel mechanisms for soil microbiome manipulation without genetically modified crops. As proof of concept, we focus on improving nitrogen supply via naringenin biosynthesis - a potential chemoattractant of free-living, nitrogen-fixing bacteria. Legal and social considerations of the project drove the development of NH-1, a low-cost, small-scale and programmable hydroponic system. Tailored to overcome experimental limitations faced by many plant scientists, NH-1 provides improved reproducibility, coupled with high-throughput experimentation. This system enabled exploration of future deployment techniques within contained environments that may result in enhanced, sustainable crop productivity at a local and accessible level.</p>
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<a class="pointer" href="https://2018.igem.org/Team:Newcastle" id="teampagelink" style="color: black"> https://2018.igem.org/Team:Newcastle</a>
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<br><br>
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</div>
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<!-- ------------------------MODAL: iGEM NEWCASTLE ------------------------------------------------------------------->
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<!-- -------------------------------------TEXT: iGEM NEWCASTLE----------------------------------------------------->
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          <p>One of our team member, Charlotte Bellamy, went to Newcastle University to meet the iGEM Newcastle team and discuss about a collaboration. The team worked on the 3D prototype of our initial photobioreactor. Furthermore, after meetings with experts, they kept supporting us in the improvement of our photobioreactor design.
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<br> <br>  </p>
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<!-- -------------------------------------TEXT: iGEM NEWCASTLE----------------------------------------------------->
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          <div class="container d-flex justify-content-center" >
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<figure  style=" width: 60%;">
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<img  src="https://static.igem.org/mediawiki/2018/thumb/7/7c/T--Newcastle--Sorbonne1.png/600px-T--Newcastle--Sorbonne1.png.jpeg"alt="schema of photobioreactor" style="width: 100%">
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    <figcaption style="padding: 10px;"><b>Figure 3: </b> 3D prototype of our initial photobioreactor </figcaption>
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  </figure>  </div>
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        </article>
  
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+
  
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/* size: 1280 */
 
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<!-- --------------------------------------------SECTION : iGEM MONTPELLIER----------------------------------------------- -->
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        <article class="col-md-10 collaboration" >
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          <!-- ---------------------MODAL : iGEM  MONTPELLIER ----------------------------------------------------->
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<div class="col-md-12 col-sm-12">
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<div class="box- box-color box-icon box-icon-center box-icon-round box-icon-large text-center pointer" data-toggle="modal" data-target="#TeammontpellierModal"  title="Do you want more information about their project ? Clic !" style = "margin:0px 0px 30px 0px !important;">
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<div class="front">
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<div class="box1 box-default">
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<div class="box-icon-title" style = "padding-bottom: 10px !important;">
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                                            <h2 id="7" class="title-h2">iGEM Montpellier</h2>
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<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/thumb/8/86/T--Sorbonne_U_Paris--LogoiGEMMontpellier.jpg/600px-T--Sorbonne_U_Paris--LogoiGEMMontpellier.jpg"  style="width: 200px"/>
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</div>
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<div id="TeammontpellierModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
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<div class="modal-dialog modal-lg">
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<div class="modal-content">
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                                <div class="container-fluid" style="background: #F4B1B8"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
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                            <span aria-hidden="true" >&times;</span>
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                                </button></div>
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                                    <!-- Modal Header -->
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<div class="modal-header" >
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<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/thumb/8/86/T--Sorbonne_U_Paris--LogoiGEMMontpellier.jpg/600px-T--Sorbonne_U_Paris--LogoiGEMMontpellier.jpg"/>
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                                        <h2 style="color: #F4B1B8; padding-bottom: 20px;">iGEM Montpellier</h2>
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                                        <h4 style="color: #F4B1B8;">Vagineering : A New Non Hormonal Contraception </h4>
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</div>
  
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<div class="modal-body">
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<h4 style="color:#F4B1B8">Abtract</h4>
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<p>Modern hormonal contraceptive methods have been revolutionary for women in developed countries; however, they still exhibit a variety of challenges. Developing countries lack consistent access, hormonal contraceptives can produce harmful environmental effects, and some women are unable use them due to health problems. The Vagineering project looks to solve these issues with a novel, non-hormonal method. Our team aims to engineer Lactobacillus jensenii, a bacterium from the vaginal flora, to produce two proteins to prevent unintentional pregnancy: antisperm antibodies that inhibit sperm motility and anti-microbial peptides (AMPs) that produce spermicidal effects. The goal is to create a lasting contraceptive using only bacteria, which can later be reversed by engineering the strain with a kill-switch. Additionally, our studies of this strain have produced a toolbox that will help other teams to further engineer this less-characterized bacterium.</p>
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<a class="pointer" href="https://2018.igem.org/Team:Montpellier"> https://2018.igem.org/Team:Montpellier</a>
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<br><br>
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<!-- ----------------------------------------MODAL: IGEM MONTPELLIER---------------------------------------------------->
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<!-- -------------------------------------TEXT: iGEM MONTPELLIER----------------------------------------------------->
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          <p>Léa Meneu and Léo Carillo, two students from the iGEM 2018 Montpellier team are pursuing their master’s degree at Sorbonne Université in Paris. So we invited them to help us introduce synthetic biology and the iGEM experience to high school students. To do so, practical sessions were organized. Several meetings between our teams were set to prepare the slides and purchase the equipments. Teaching students was a very nice opportunity to learn how to explain our project with simple words. </p>
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<p>To learn more about this practical work at High school Maurice Genevoix (city of Montrouge),go to our Human practices page section “Public engagement and education”.
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        <div class="col-xs-4 col-sm-4 col-md-12 col-lg-12">
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        <a class="btn-sm" href="https://2018.igem.org/Team:Sorbonne_U_Paris/Human_Practices" role="button" style=" color:white; border-radius: 10px; background-color:#22D66C; text-decoration:none; "><i class="fas fa-handshake fa-1x"></i> Human practices</a> 
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    <!-- .\ human practices--> </p><br><br>
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          <div class="container d-flex justify-content-center" >
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<figure  style=" width: 80%;">
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<img  src="https://static.igem.org/mediawiki/2018/9/96/T--Sorbonne_U_Paris--Pratical_work_grouppicture.jpg"alt="Practical work" style="width: 100%">
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    <figcaption style="padding: 10px;"><b>Figure 4: </b> Pratical work for  2nd-year high school students at Maurice Genevoix High school (Montrouge, France) (8th October 2018) Léo CARRILLO, Léa MENEU (Montpellier team), Asmaa FODA, Saniya KARI (Sorbonne U team) and the high school students </figcaption>
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  </figure>  </div>
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        </article>
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<!-- --------------------------------------------SECTION: iGEM MARBURG-------------------------------------------------- -->
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        <article class="col-md-10 collaboration">
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<div class="col-md-12 col-sm-12">
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<div class="box- box-color box-icon box-icon-center box-icon-round box-icon-large text-center pointer" data-toggle="modal" data-target="#TeamMarburgModal"  title="Do you want more information about their project ? Clic !" style = "margin:0px 0px 30px 0px !important;">
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<div class="front">
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<div class="box1 box-default">
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<div class="box-icon-title" style = "padding-bottom: 10px !important;">
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                                            <h2 id="8" class="title-h2">iGEM Marburg</h2>
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<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/e/e2/T--Sorbonne_U_Paris--Logo_IgemMarburg.png"  style="width: 300px"/>
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<div id="TeamMarburgModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
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<div class="modal-dialog modal-lg">
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<div class="modal-content">
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                                <div class="container-fluid" style="background: #5BB12F"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
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                            <span aria-hidden="true" >&times;</span>
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                                </button></div>
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                                    <!-- Modal Header -->
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<div class="modal-header" >
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<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/e/e2/T--Sorbonne_U_Paris--Logo_IgemMarburg.png"/>
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                                        <h2 style="color: black; padding-bottom: 20px;">iGEM Marburg</h2>
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                                        <h4 style="color: black">Vibrigens - Accelerating Synbio<br>: Establishing Vibrio natriegens as the new chassis organism for synthetic biology</h4>
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</div>
  
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<!-- Modal Body -->
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<div class="modal-body">
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<h4 style="color:black">Abtract</h4>
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<p>Waiting for cells to grow is an enormous time sink for synthetic biologists. Cloning cycles with the current standard, Escherichia coli, typically take up to three days. In our project Vibrigens - Accelerating Synbio, we established the tools to turn Vibrio natriegens into the next generation chassis for synthetic biology, ready to be used reliably. By taking advantage of its unbeaten doubling time of 7 minutes, we substantially reduced waiting time and made one-day-cloning a reality. We built and characterized a flexible golden-gate-based part collection, consisting of more than 100 parts, which enables the creation of complex pathways in a short amount of time. Our engineered V. natriegens strains VibriClone and VibriExpress are designed for cloning and protein expression applications, respectively. Moreover, we established the first synthetic metabolic pathway in this organism by producing the platform chemical 3-Hydroxypropionate and along the way developed an accelerated workflow for metabolic engineering..</p>
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<a class="pointer" href="https://2018.igem.org/Team:Marburg" id="teampagelink" style="color: black"> https://2018.igem.org/Team:Marburg</a>
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<br><br>
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          <p>As a part of their Human Practices project, they aim to make the iGEM competition accessible to everyone. The iGEM Marburg team sent us a message to participate in the design of an accessible wiki to everyone. Through several emails, we helped each other to write the guide “Accessible webdesign”. We tried to write the guide with easy words and bring examples so that beginners can easily apprehend this wiki concept. The long-term goal is for all iGEM teams to design their wiki without difficulties. We also helped each other improve various parts of our respective wikis. They made a logo to indicate that our wiki is accessible and we put it in the footer of our wiki.</p>
  
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To read the “accessible webdesign-guide navigation”, visit the Human practices page of iGEM Marburg.
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        <a class="btn-sm" href="https://2018.igem.org/Team:Marburg/Human_Practices" role="button" style=" color:white; border-radius: 10px; background-color:#22D66C; text-decoration:none; "><i class="fas fa-handshake fa-1x"></i> Human practices</a> 
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<img  src="https://static.igem.org/mediawiki/2018/7/70/T--Sorbonne_U_Paris--Accessibility_logo.png"alt="Accessibility logo" style="width: 100%">
 +
    <figcaption style="padding: 10px;"><b>Figure 5: </b> Accessibility logo made by the iGEM Marburg. This logo informs people that the wiki is accessible. </figcaption>
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  </figure>  </div>
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        </article>
  
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        <article class="col-md-10 collaboration">
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                  <!-- ---------------------MODAL : iGEM IIT Madras ----------------------------------------------------->
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<div class="col-md-12 col-sm-12">
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<div class="box- box-color box-icon box-icon-center box-icon-round box-icon-large text-center pointer" data-toggle="modal" data-target="#TeamITTMadrasModal"  title="Do you want more information about their project ? Clic !" style = "margin:0px 0px 30px 0px !important;">
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<div class="front">
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                                            <h2 id="6" class="title-h2">iGEM  IIT Madras</h2><br>
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<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/b/bb/T--Sorbonne_U_Paris--Logo_iGEMIITMadras.png"style="width: 200px"/>
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                            <span aria-hidden="true" >&times;</span>
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                                </button></div>
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                                    <!-- Modal Header -->
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<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/b/bb/T--Sorbonne_U_Paris--Logo_iGEMIITMadras.png"/>
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                                        <h2 style="color: #00B055; padding-bottom: 20px;">iGEM  IIT Madras</h2>
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                                        <h4 style="color: #00B055">ADaPtat1on : Expanding Toolkit for Acinetobacter baylyi </h4>
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</div>
  
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<h4 style="color:#00B055">Abtract</h4>
 +
<p>
 +
Acinetobacter baylyi is a gram-negative, soil-dwelling, non-pathogenic, naturally competent and nutritionally versatile organism especially known for its ability to degrade aromatic compounds. However, only a few tools are available for its gene manipulation. This year, we plan to expand the toolkit for A. baylyi ADP1 by making a synthetic promoter library along with codon optimized fluorescent reporter proteins to achieve better control over its expression rates. The codon table is not available for this organism. So we obtained sequence data of well-characterised proteins of this organism by filtering manually putative and hypothetical sequences and used this data to generate the codon table using CUTE - a tool of ChassiDex. The codon optimisation is done manually by replacing the less frequent codons with high-frequency codons based on the generated table. This can potentially open up various new exciting synthetic biology opportunities with this unexplored organism. </p>
 +
<a class="pointer" href="https://2018.igem.org/Team:IIT-Madras" id="teampagelink" style="color: #00B055"> https://2018.igem.org/Team:IIT-Madras</a>
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<br><br>
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          <p> IIT Madras asked us for a collaboration to translate educational synthetic biology videos into our native languages. So we translated some of their video scripts to French, Italian and Persian. We also recorded the audio of some videos: the “DNA and RNA” video in French and Italian and the “introduction of synthetic biology” video in Persian. It was a real pleasure to help them in this fantastic initiative!</p>
 +
<p><i class="fab fa-youtube fa-2x" style="color:red"></i> The italian version of DNA and RNA is available on youtube at this link <a class="link-inside-page" href="https://www.youtube.com/watch?v=UuVNUM_MJyY">Italian - DNA & RNA : Language Project</a> </p> 
 +
<p><i class="fab fa-youtube fa-2x" style="color:red"></i> The French version of DNA and RNA is available on youtube at this link <a class="link-inside-page" href="https://www.youtube.com/watch?v=9EjxvGZZ24c">French- DNA & RNA : Language Project</a> </p>
 +
<p><i class="fab fa-youtube fa-2x" style="color:red"></i> The Persian version of DNA and RNA is available on youtube at this link <a class="link-inside-page" href="https://www.youtube.com/watch?v=CFTv7S5UHnA">Persian - DNA & RNA : Language Project</a> </p>   
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        </article>
  
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        <article class="col-md-10 collaboration">
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                  <!-- ---------------------MODAL : iGEM WASHINGTON ----------------------------------------------------->
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<div class="col-md-12 col-sm-12">
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<div class="box- box-color box-icon box-icon-center box-icon-round box-icon-large text-center pointer" data-toggle="modal" data-target="#TeamWashingtonModal"  title="Do you want more information about their project ? Clic !" style = "margin:0px 0px 30px 0px !important;">
 +
<div class="front">
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<div class="box-icon-title" style = "padding-bottom: 10px !important;">
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                                            <h2 id="9" class="title-h2">iGEM  Washington</h2><br>
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<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/c/c8/T--Sorbonne_U_Paris--Logo_iGEMWashington.png"style="width: 200px"/>
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</div>
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</div>
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</div>
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<div id="TeamWashingtonModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
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<div class="modal-dialog modal-lg">
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<div class="modal-content">
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                                <div class="container-fluid" style="background: #420DAB"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
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                            <span aria-hidden="true" >&times;</span>
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                                </button></div>
 +
                                                           
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                                    <!-- Modal Header -->
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<div class="modal-header" >
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<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/c/c8/T--Sorbonne_U_Paris--Logo_iGEMWashington.png"/>
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                                        <h2 style="color: #420DAB; padding-bottom: 20px;">iGEM  Washington</h2>
 +
                                        <h4 style="color: #420DAB">Stronger Together: An efficient, generalizable approach to design biosensors for small molecules</h4>
 +
</div>
  
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<h4 style="color:#420DAB">Abtract</h4>
 +
<p>
 +
Chemically induced dimerization (CID), in which two proteins dimerize only in the presence of a small molecule, has been widely used to control cell signaling, regulatory, and metabolic pathways, and used as logic gates for biological computation in living mammalian cells. However, few naturally occuring CID systems and their derivatives are currently available. Creating a CID system with desired affinity and specificity for any given small molecule remains an unsolved problem for computational design and other protein engineering approaches. To address this challenge, we have used a novel strategy to select CID binders from a vastly diverse combinatorial nanobody library. We have created new CID systems that can sense cholecalciferol and artemisinin. We are validating CID biosensors by a yeast three-hybrid system and built structural models to understand the small molecule-induced dimerization. Our work is a proof-of-concept that can be generalized to create CID systems for many applications. </p>
 +
<a class="pointer" href="https://2018.igem.org/Team:Washington" id="teampagelink" style="color: #420DAB"> https://2018.igem.org/Team:Washington</a>
 +
<br><br>
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</div>
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                                                                        <div  class="modal-footer" style="background: #420DAB"  >
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          <p>iGEM Washington team has created a Synthetic Biology Activity Booklet. This Booklet contains outreach activities for children. They wanted it to be accessible to the entire iGEM community. Therefore, they asked us to translate their booklet in French. This aims to allow the future French teams to improve their public engagement part by explaining synthetic biology to children with fun.
 +
</p>
  
 +
<div class="container d-flex justify-content-center" >
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<figure  style=" width: 60%;">
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<img  src="https://static.igem.org/mediawiki/2018/e/e9/T--Sorbonne_U_Paris--Whasington_booklet.jpg"alt="Cover of synthetic activity booklet" style="width: 100%">
 +
    <figcaption style="padding: 10px;"><b>Figure 6: </b>Synthetic biology activity booklet cover that we trannslated into French </figcaption>
 +
  </figure>  </div>
 +
     
 +
        </article>
  
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                                            <h2 id="5" class="title-h2">iGEM  Duesseldorf</h2>
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<div id="TeamDuesseldorfModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
 +
<div class="modal-dialog modal-lg">
 +
<div class="modal-content">
 +
                                <div class="container-fluid" style="background: #C69F34"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
 +
                            <span aria-hidden="true" >&times;</span>
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                                </button></div>
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                                    <!-- Modal Header -->
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<div class="modal-header" >
 +
<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/8/8c/T--Sorbonne_U_Paris--Logo_iGEMDuesseldorf.png"/>
 +
                                        <h2 style="color: #016A62; padding-bottom: 20px;">iGEM  Duesseldorf</h2>
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                                        <h4 style="color: #016A62">Trinity - towards an engineered co-culture toolbox</h4>
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<h4 style="color:#016A62">Abtract</h4>
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<p>Co-cultures are found in all conceivable entities, such as the human gut, cheese or plants, but good tools to study those communities are currently not given. Indeed we created a modularly built toolbox using not only three different dependencies but also three different organisms: With Escherichia coli, Saccharomyces cerevisiae and Synechococcus elongatus our team engineered a system based on nutrient exchange. Here phosphate is provided through oxidation of phosphite, nitrogen source produced by melamine breakdown, whilst carbon source is provided by Synechococcus elongatus. Two additional independent approaches are designed, too. The first includes regulation via cross-feeding by amino acid auxotrophies and production: lysine by Escherichia coli and leucine by Saccharomyces cerevisiae. The other utilizes regulated self-lysis via quorum sensing molecules, to control cell density by a phage lysis gene. This engineered toolbox opens a wide range of possibilities to create microbial communities for different purposes, such as synthetic probiotics.</p>
 +
<a class="pointer" href="https://2018.igem.org/Team:Duesseldorf" id="teampagelink" style="color: #016A62"> https://2018.igem.org/Team:Duesseldorf</a>
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<br><br>
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</div>
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                                                                        <div  class="modal-footer" style="background: #C69F34"  >
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</div>
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</div>
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</div>
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<!-- ------------------------MODAL: iGEM IIT MADRAS--------------------------------------------------------------->
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<!-- -------------------------------------TEXT: iGEM DUESSELDORF----------------------------------------------------->
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          <p>
 +
Duesseldorf created a project to promote synthetic biology using self-designed postcards. Every participating team designed a postcard related to synthetic biology or their respective project topic. To spread the iGEM team’s innovative ideas, different teams exchanged their postcards. The postcards were then received and collected all over the world and could be shared with the general public during events...
 +
The postcard we made reinvented the famous painting of the Liberty guiding the people: "La liberté guidant le peuple" by Eugène Delacroix. Our microalgae, Claude, is there leading the way to the Sugar Revolution.
  
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<img  src="https://static.igem.org/mediawiki/2018/1/1f/T--Sorbonne_U_Paris--Postalcard.jpg" style="width: 100%">
 +
    <figcaption style="padding: 10px;"><b>Figure 7: </b>Postal card sent to the iGEM teams "La liberté guidant le people" by Eugène Delacroix, </figcaption>
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 +
<div class="front">
 +
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<div class="box-icon-title" style = "padding-bottom: 10px !important;">
 +
                                            <h2 id="2" class="title-h2">iGEM Pasteur</h2><br>
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<img class="img-fluid" src="https://static.igem.org/mediawiki/2018/5/5c/T--Sorbonne_U_Paris--Logo_IGEMPasteur.png" alt="Logo iGEM Pasteur"  style="width: 200px"/>
 +
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 +
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 +
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 +
 +
<div id="TeamPasteurModal" class="modal fade bs-example-modal-lg" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true">
 +
<div class="modal-dialog modal-lg">
 +
<div class="modal-content">
 +
                                <div class="container-fluid" style="background: black"><button type="button" class="close" data-dismiss="modal" aria-label="Close">
 +
                            <span aria-hidden="true" >&times;</span>
 +
                                </button></div>
 +
                                                           
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 +
                                    <!-- Modal Header -->
 +
<div class="modal-header" >
 +
<img class="img-responsive" style="width:20%; padding-top: 30px;" src="https://static.igem.org/mediawiki/2018/5/5c/T--Sorbonne_U_Paris--Logo_IGEMPasteur.png"/>
 +
                                        <h2 style="color: black; padding-bottom: 20px;">iGEM Pasteur</h2>
 +
                                        <h4 style="color: black">NeuronArch: <br> the novel connecting and protecting biofilm based system for prostheses</h4>
 +
</div>
  
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<h4 style="color:black">Abtract</h4>
 +
<p>In the future, a long due consideration and an easier access to healthcare will be given to people with disabilities. Presently, some prostheses allow amputees to perform simple actions but without a direct connection between the nerves and the prosthesis. Furthermore, a major health risk is the development of pathogenic communities of microorganisms in structures called biofilms. Strong treatments with antibiotics, or even surgical reinterventions are then required. They represent a heavy burden for both the patient and the healthcare system. We imagined NeuronArch as a novel application that subverts potential pathogenic biofilms using an engineered one. This interface produces substances called neurotrophins (NGF), for directed and controlled growth of nerves. Using a conductive membrane, it will also allow passing of information and enhancement of the electrical properties. Altogether, these improvements would enable patients to regain natural perceptions and prevent the formation of Staphylococcus aureus biofilms by blocking quorum sensing.</p>
 +
<a class="pointer" href="https://2018.igem.org/Team:Pasteur_Paris" id="teampagelink" style="color: black"> https://2018.igem.org/Team:Pasteur_Paris</a>
 +
<br><br>
 +
 +
</div>
 +
                                                                        <div  class="modal-footer" style="background: black"  >
 +
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</div>
 +
</div>
 +
</div>
 +
</div>
 +
<!-- ------------------------MODAL: iGEM PASTEUR---------------------------------------------------->
 +
<!-- -------------------------------------TEXT: iGEM PASTEUR---------------------------------------------------->
 +
      <p>We collaborated with the iGEM Pasteur team on the InterLab measurement study. We gave them the E. coli DH5 alpha strain they needed for the InterLab. In return, they answered some questions concerning the InterLab.  </p>
  
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Latest revision as of 02:00, 18 October 2018

Our collaborations

The availability of new technologies has facilitated the exchanges worldwide and so promoted multidisciplinarity and collaboration in science. Collaboration is a key part among iGEMers. Indeed, collaborations help to achieve goals that would not be fulfilled alone. This year the Sorbonne U Paris 2018 team has been collaborating with 9 iGEM teams from all over the world. Herein, we detail the nature of all of our collaborations with these awesome teams with whom we shared great moments for which thank them a lot!

By clicking on our collaborators' logos, you will have access to the abstract of their project.

iGEM Go Paris Saclay

The iGEM Go Paris Saclay team and us have built a very strong relationship and have faced various challenges together. Their mathematicians introduced us to the bio-modeling bases. We could implement our essential retrotransposons' biological data into the model created together. Indeed, this model aimed to simulate the behavior of our retrotransposons. So, we are able to generate a data bank to select the best parts for our system.

For more information about our modelling visit our modelling page.

Modelling page

On our side, Céline, our former wiki manager, taught some members of the iGEM Paris Saclay team to code, in order to realize their wiki page and Saniya has been an advisor.

Marie-Charlotte realized several sketches of their logo for a submission to a design agency.

They also took part in the organization of the conference untitled “What will synthetic biology bring to the future?” hosted on the Campus Pierre et Marie Curie of Sorbonne Université. They helped us contact experts and purchase food and materials for the buffet through a communal fund.

Further information about this conference are available on the Human practices pages section “Public engagement and education”.

Human practices



Meeting with The iGEM Saclay team for modelling
Figure 1: Meeting with The Paris Saclay Team for modelling
From left to right : Raphaël GUEGAN, Kenn PAPADOPOULO, Guillaume GARNIER, Ousmane DAO, Victor SAYOUS and Céline MORIN

iGEM Bordeaux

“Friendship is born at that moment when one person says to another: “What! You too? I thought I was the only one.” (C.S Lewis). It is the perfect quote to sum up our collaboration with the iGEM Bordeaux team. We first met at the Parisian meetup in Paris (7th July 2018). As we share the same conception of an iGEM project, our partnership was obvious. We invited them to participate to the organization of the conference “What will synthetic biology bring to the future?”. They helped us a lot to contact experts.

Poster of Conference
Figure 2: Poster of the conference intitled "What will synthetic biology bring to the future?" (26th September 2018)

iGEM Newcastle

One of our team member, Charlotte Bellamy, went to Newcastle University to meet the iGEM Newcastle team and discuss about a collaboration. The team worked on the 3D prototype of our initial photobioreactor. Furthermore, after meetings with experts, they kept supporting us in the improvement of our photobioreactor design.

schema of photobioreactor
Figure 3: 3D prototype of our initial photobioreactor

iGEM Montpellier

Léa Meneu and Léo Carillo, two students from the iGEM 2018 Montpellier team are pursuing their master’s degree at Sorbonne Université in Paris. So we invited them to help us introduce synthetic biology and the iGEM experience to high school students. To do so, practical sessions were organized. Several meetings between our teams were set to prepare the slides and purchase the equipments. Teaching students was a very nice opportunity to learn how to explain our project with simple words.

To learn more about this practical work at High school Maurice Genevoix (city of Montrouge),go to our Human practices page section “Public engagement and education”.

Human practices



Practical work
Figure 4: Pratical work for 2nd-year high school students at Maurice Genevoix High school (Montrouge, France) (8th October 2018) Léo CARRILLO, Léa MENEU (Montpellier team), Asmaa FODA, Saniya KARI (Sorbonne U team) and the high school students

iGEM Marburg

As a part of their Human Practices project, they aim to make the iGEM competition accessible to everyone. The iGEM Marburg team sent us a message to participate in the design of an accessible wiki to everyone. Through several emails, we helped each other to write the guide “Accessible webdesign”. We tried to write the guide with easy words and bring examples so that beginners can easily apprehend this wiki concept. The long-term goal is for all iGEM teams to design their wiki without difficulties. We also helped each other improve various parts of our respective wikis. They made a logo to indicate that our wiki is accessible and we put it in the footer of our wiki.

To read the “accessible webdesign-guide navigation”, visit the Human practices page of iGEM Marburg.

Human practices



Accessibility logo
Figure 5: Accessibility logo made by the iGEM Marburg. This logo informs people that the wiki is accessible.

iGEM IIT Madras


IIT Madras asked us for a collaboration to translate educational synthetic biology videos into our native languages. So we translated some of their video scripts to French, Italian and Persian. We also recorded the audio of some videos: the “DNA and RNA” video in French and Italian and the “introduction of synthetic biology” video in Persian. It was a real pleasure to help them in this fantastic initiative!

The italian version of DNA and RNA is available on youtube at this link Italian - DNA & RNA : Language Project

The French version of DNA and RNA is available on youtube at this link French- DNA & RNA : Language Project

The Persian version of DNA and RNA is available on youtube at this link Persian - DNA & RNA : Language Project

iGEM Washington


iGEM Washington team has created a Synthetic Biology Activity Booklet. This Booklet contains outreach activities for children. They wanted it to be accessible to the entire iGEM community. Therefore, they asked us to translate their booklet in French. This aims to allow the future French teams to improve their public engagement part by explaining synthetic biology to children with fun.

Cover of synthetic activity booklet
Figure 6: Synthetic biology activity booklet cover that we trannslated into French

iGEM Duesseldorf

Duesseldorf created a project to promote synthetic biology using self-designed postcards. Every participating team designed a postcard related to synthetic biology or their respective project topic. To spread the iGEM team’s innovative ideas, different teams exchanged their postcards. The postcards were then received and collected all over the world and could be shared with the general public during events... The postcard we made reinvented the famous painting of the Liberty guiding the people: "La liberté guidant le peuple" by Eugène Delacroix. Our microalgae, Claude, is there leading the way to the Sugar Revolution.

Figure 7: Postal card sent to the iGEM teams "La liberté guidant le people" by Eugène Delacroix,

iGEM Pasteur


Logo iGEM Pasteur

We collaborated with the iGEM Pasteur team on the InterLab measurement study. We gave them the E. coli DH5 alpha strain they needed for the InterLab. In return, they answered some questions concerning the InterLab.

Pasteur team
Figure 8: Meeting with the iGEM Pasteur team (24th May 2018)
From top to bottom and left to right : Ellyn Redheuil, Dounia Chater, Sarah Porte, Antoine Ehret, Victor Sayous, Emma Picaud-Lucet (1st row), Léa Guerassimoff, Alice Dejoux, Samuel Jaoui, Sarah khalilian and Saniya Kari (2nd row)
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