Difference between revisions of "Team:Goettingen/Description"

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<h1>Description</h1>
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                    <h2>Glyphosate on my plate?!<br/>A bacterial roundup solution to the glyphosate controversy</h2>
<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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                    <p>Feeding the steadily increasing world population is a major task that relies heavily on the use of fertilizers and herbicides. Glyphosate is the prominent example for a total-herbicide. Glyphosate has been the most used herbicide in the US for the past decades, while still showing an upward trend in its usage rate. The Herbicide is a controversial substance, as its effects on human health and the environment still remains unsure, with some sources stating the suspicion for it to be carcinogenic. It also could pose a threat to biodiversity, but no real long-term studies have been carried out so far in this regard. Our team has set itself the goal to approach the glyphosate controversy through a microbial reporter system, using the well-known model organism <i>Bacillus subtilis</i>. This system should be able to detect and indicate the presence of glyphosate. During our studies we also aim to enhance the understanding of the effects of glyphosate on bacteria. We want to show how it is taken up into the bacterial cell and which pathways are affected by it. We will present our work on the development of glyphosate-resistant <i>B. subtilis</i> strains. Using these suppressor mutants, we could for the first time identify a protein that is capable of transporting glyphosate. The glyphosate-resistant strains could even provide the possibility to develop a glyphosate degradation pathway, based on the hypothesis that Bacillus might use glyphosate as its carbon source. Our human practice section is dedicated to the raise of awareness for Glyphosate and microbial research, while simultaneously cooperating with other scientific labs to achieve our goal. In the end, this should provide an updated view on the Glyphosate controversy with renewed insights into the effects of the herbicide on organisms and possibly solution approaches with Glyphosate resistances.</p>
 
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                    <p style="font-weight: bold; font-size:1.1em">iGEM-Team Göttingen, Georg-August University Göttingen, Germany</p>
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                            <th>Members:</th><td>Rica Bremenkamp, Malte Holmer, Jonas Jennrich, Veronika Lutz, Janek Meißner, Lisa Schulz, Robert Warneke, Marie Wensien, Dennis Wicke</td>
 
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<h3>What should this page contain?</h3>
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                            <th>Supervisors:</th><td>Prof. Jörg Stülke, Dr. Fabian Commichau</td>
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<li> A clear and concise description of your project.</li>
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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<li>References and sources to document your research.</li>
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<li>Use illustrations and other visual resources to explain your project.</li>
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<h3>Inspiration</h3>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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<h3>Advice on writing your Project Description</h3>
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.  
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<h3>References</h3>
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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Revision as of 08:21, 29 June 2018

Glyphosate on my plate?!
A bacterial roundup solution to the glyphosate controversy

Feeding the steadily increasing world population is a major task that relies heavily on the use of fertilizers and herbicides. Glyphosate is the prominent example for a total-herbicide. Glyphosate has been the most used herbicide in the US for the past decades, while still showing an upward trend in its usage rate. The Herbicide is a controversial substance, as its effects on human health and the environment still remains unsure, with some sources stating the suspicion for it to be carcinogenic. It also could pose a threat to biodiversity, but no real long-term studies have been carried out so far in this regard. Our team has set itself the goal to approach the glyphosate controversy through a microbial reporter system, using the well-known model organism Bacillus subtilis. This system should be able to detect and indicate the presence of glyphosate. During our studies we also aim to enhance the understanding of the effects of glyphosate on bacteria. We want to show how it is taken up into the bacterial cell and which pathways are affected by it. We will present our work on the development of glyphosate-resistant B. subtilis strains. Using these suppressor mutants, we could for the first time identify a protein that is capable of transporting glyphosate. The glyphosate-resistant strains could even provide the possibility to develop a glyphosate degradation pathway, based on the hypothesis that Bacillus might use glyphosate as its carbon source. Our human practice section is dedicated to the raise of awareness for Glyphosate and microbial research, while simultaneously cooperating with other scientific labs to achieve our goal. In the end, this should provide an updated view on the Glyphosate controversy with renewed insights into the effects of the herbicide on organisms and possibly solution approaches with Glyphosate resistances.

iGEM-Team Göttingen, Georg-August University Göttingen, Germany

Members:Rica Bremenkamp, Malte Holmer, Jonas Jennrich, Veronika Lutz, Janek Meißner, Lisa Schulz, Robert Warneke, Marie Wensien, Dennis Wicke
Supervisors:Prof. Jörg Stülke, Dr. Fabian Commichau