Difference between revisions of "Team:Jilin China"

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Revision as of 20:36, 17 October 2018

The Collection of
SynRT
with Different Sensing Temperatures

ABSTRACT

Many strategies could be used to regulate the gene expression responding to temperature changes in bacterial cells. A well-known class of biological thermoregulatory elements includes RNA-based thermosensors (RTs), which are located in the 5'- untranslated region in mRNA. RTs could sense temperature shift and influence the mRNA stability or ribosome accessibility, thereby controlling translation efficiency.

However, natural RNA-based thermosensors have complex structure and narrow sensing temperature range, which become the biggest limitation in their application. To address this issue, we have created a synthetic RNA-based thermosensor (SynRT) toolkit with different sensing temperatures. Additionally, we built a matched search engine for users.

The SynRT toolkit version has been updated from 1.0 to 3.0, and the latest version is composed of four types of SynRTs:

SD Sequence anti-SD Sequence Ribosome

Hot-induced 5'UTR

RC anti-RC RNAse E
Stroke Version_1 RC RNAse III

Human Practices

Several Exploration Improved

OUR TOOLKITs

meanwhile Inspiring Us to Make

A DECADE
WORKFLOW

Several Innovative Kits

Promoting Us to

SPREAD and DISCUSS

Synthetic Biology


Model

https://static.igem.org/mediawiki/2018/c/c1/T--Jilin_China--model--shouye.png

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Title