Difference between revisions of "Team:Calgary"

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         <!-- Page 2 -->
 
         <!-- Page 2 -->
 
         <div class="section">
 
         <div class="section">
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             <div class="section-content">
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                 <h1 style="text-align: left; transform: translateX(20px); color: #44414d">The ideal medicine is not a
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                 <h2 style="text-align: left; color: #44414d">The ideal medicine is not a perfect treatment . . .</h2>
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                    perfect treatment
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−
                    . . .</h1>
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                 <br>
 
                 <br>
 
                 <br>
 
                 <br>
 
                 <br>
 
                 <br>
−
                 <br>
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                 <h2 style="text-align: right; color: #44414d">. . . it's a <span style="color: #7ccfb8">cure</span></h2>
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                <h1 style="text-align: right; transform: translateX(-20px); color: #44414d">. . . it's a <span style="color: #7ccfb8">cure</span></h1>
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             </div>
 
             </div>
 
         </div>
 
         </div>
 
         <!-- Page 3 -->
 
         <!-- Page 3 -->
 
         <div class="section">
 
         <div class="section">
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             <div class="section-content">
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                 <div>
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                 <h2 style="text-align: left; color: #44414d">Advancements in genetic modification have opened avenues
−
                    <p style="text-align: left">
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                    towards numerous tracks of scientific
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                        Advancements in genetic modification have applications in scientific
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                    development.</h2>
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                        fields. In particular,
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                        the demand for permanent health solutions has sparked massive interest in gene therapy.
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−
                    </p>
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                </div>
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                 <br>
 
                 <br>
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                 <div>
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                 <br>
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                    <p style="text-align: left">
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                <br>
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                        Despite the potential for establishing an ideal medicine, there are still numerous challenges.
+
                <h2 style="text-align: left; color: #44414d">In particular,
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                        The selection of an integration target site,
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                    the demand for permanent health solutions has sparked massive interest in <span style="color: #7ccfb8">gene
−
                        methodology pertaining to gene
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                         therapy</span>.</h2>
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                         delivery, and maintenance of gene expression currently limit the potential for gene therapy
+
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                        to become common practice.
+
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                    </p>
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                </div>
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             </div>
 
             </div>
 
         </div>
 
         </div>
 
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         <!-- Page 4 -->
 
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                 <p style="text-align: center">How do we overcome these problems?</p>
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                 <h2 style="text-align: left; color: #44414d">Despite the potential for establishing an ideal medicine,
−
                 <br><br>
+
                    there are still numerous challenges.</h2>
−
                 <h1 class="home-title">SNIP
+
                 <br>
−
                    <span style="color: #7ccfb8">EQUIP</span> FLIP</h1>
+
                <br>
−
                <p style="text-align: center">The system that allows for the integration and maintenance of large-scale genetic constructs in eukaryotic systems.</p>
+
                 <br>
 +
                <h2 style="text-align: left; color: #44414d">The selection of an <span style="color: #7ccfb8">integration
 +
                        target site</span>,
 +
                    methodology pertaining to <span style="color: #7ccfb8">gene
 +
                        delivery</span>, and <span style="color: #7ccfb8">maintenance</span> of gene expression
 +
                    currently limit the potential for gene
 +
                    therapy
 +
                    to become common practice.</h2>
 
             </div>
 
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         </div>
 
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         <!-- Page 5 -->
 
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                 <div>
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                 <h2 style="text-align: center; color: #44414d">How do we overcome these problems?</h2>
−
                    <p style="text-align: left">
+
−
                        University of Calgary’s Snip, Equip, Flip aims to overcome the aforementioned obstacles.
+
−
                        This system enables the creation of eukaryotic cell lines via stable integration and expression of exogenous
+
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                        genes.
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                    </p>
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                </div>
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                 <br>
 
                 <br>
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                 <br>
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                    <p style="text-align: left">
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                <br>
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                        Snip, Equip, Flip is a simple and reliable method that can be used by experienced and entrant
+
                <h2 style="text-align: center; color: #44414d" class="home-title">SNIP
−
                        researchers
+
                     <span style="color: #7ccfb8">EQUIP</span> FLIP</h2>
−
                        alike that can lead to a vast array of scientific discoveries.
+
                 <br>
−
                     </p>
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                <br>
−
                 </div>
+
                <h2 style="text-align: center; color: #44414d">The system that allows for the integration and
 +
                    maintenance of large-scale genetic constructs in eukaryotic systems.</h2>
 
             </div>
 
             </div>
 
         </div>
 
         </div>
 
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         <div class="section">
−
             <div class="row">
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             <h2 style="text-align: left; color: #44414d">University of Calgary’s Snip, Equip, Flip aims to overcome
−
                 <div>
+
                 the aforementioned obstacles. This system
−
                    <p style="text-align: left">
+
                allows for the creation of eukaryotic cell lines via stable integration and expression of exogenous
−
                        By complementing the specific targeting that CRISPR/Cas9 offers with the much larger
+
                genes.</h2>
−
                        integration
+
            <br>
−
                        capabilities of FLP recombinase and beta resolvase, gene integration into eukaryotic genomes
+
            <br>
−
                        becomes a
+
            <br>
−
                        simple process of Snip, Equip, Flip.
+
            <h2 style="text-align: left; color: #44414d">Snip, Equip, Flip is a simple and reliable method that can
−
                    </p>
+
                be used by experienced and entrant
−
                </div>
+
                researchers alike that can lead to a vast array of scientific discoveries.</h2>
−
                <br>
+
        </div>
−
                <div>
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        <!-- Page 7 -->
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        <div class="section">
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                        The expression of integrated genes is then protected and maintained over time by adding
+
            <h2 style="text-align: left; color: #44414d">By complementing the specificity of targeting that
−
                        flanking
+
                CRISPR/Cas9 offers with the much larger integration
−
                        chromatin modifying elements.
+
                capabilities of FLP recombinase and beta resolvase, gene integration into eukaryotic genomes becomes a
−
                    </p>
+
                simple process of Snip, Equip, Flip.</h2>
−
                </div>
+
            <br>
−
              <br>
+
            <br>
−
                <div style="text-align: center">
+
            <br>
 +
            <h2 style="text-align: left; color: #44414d">The expression of integrated genes is then protected and
 +
                maintained over time by adding flanking
 +
                chromatin modifying elements.</h2>
 +
            <br>
 +
            <div style="text-align: center">
 
                 <a href="https://2018.igem.org/Team:Calgary/Description"><button style="font-size: 20px" type="button"
 
                 <a href="https://2018.igem.org/Team:Calgary/Description"><button style="font-size: 20px" type="button"
−
                         class="btn btn-outline-dark btn-lg">Our System</button></a>
+
                         class="btn btn-outline-dark btn-lg">Our
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                </div>
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                        System</button></a>
−
             
+
 
             </div>
 
             </div>
 
         </div>
 
         </div>

Revision as of 03:03, 18 October 2018

Team:Calgary - 2018.igem.org

SNIP EQUIP FLIP

image/svg+xml

The ideal medicine is not a perfect treatment . . .




. . . it's a cure

Advancements in genetic modification have opened avenues towards numerous tracks of scientific development.




In particular, the demand for permanent health solutions has sparked massive interest in gene therapy.

Despite the potential for establishing an ideal medicine, there are still numerous challenges.




The selection of an integration target site, methodology pertaining to gene delivery, and maintenance of gene expression currently limit the potential for gene therapy to become common practice.

How do we overcome these problems?




SNIP EQUIP FLIP



The system that allows for the integration and maintenance of large-scale genetic constructs in eukaryotic systems.

University of Calgary’s Snip, Equip, Flip aims to overcome the aforementioned obstacles. This system allows for the creation of eukaryotic cell lines via stable integration and expression of exogenous genes.




Snip, Equip, Flip is a simple and reliable method that can be used by experienced and entrant researchers alike that can lead to a vast array of scientific discoveries.

By complementing the specificity of targeting that CRISPR/Cas9 offers with the much larger integration capabilities of FLP recombinase and beta resolvase, gene integration into eukaryotic genomes becomes a simple process of Snip, Equip, Flip.




The expression of integrated genes is then protected and maintained over time by adding flanking chromatin modifying elements.


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