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-Liver cancer is cancer that begins in the cells of your liver. By the end of 2017, the incidence rate of liver cancer in China ranks the third in the world, and the mortality rate is the second. At present, the treatment methods of liver cancer include surgical resection, liver transplantation, local ablation, interventional therapy, radiotherapy, targeted therapy, immunotherapy and so forth.
-Our project is to design a series of genetic circuits which specifically kill tumors, whose main components includes liver cancer cell cell-specific promoter, microRNA binding domain, GAL - 4 and GAL-80, thymidine kinase (TK) for gene therapy , etc.
-The main principle of this loop is as follows: In liver cancer cells, there is a specific promoter that can activate the transcription and expression of GAL-4, so that a small dose of GAL-4 can bind to the upstream of the gene expressing TK, thereby triggering TK kinase to achieve tumor killing effect by gene therapy. And due to the lack of this specific promoter in normal cells, GAL-80 also has a normal inhibitory effect on GAL-4, so the loop is in an overall suppressed state.