Team:CSU CHINA

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Description

The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. Prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock (clock-controlled).

We hope to construct a system which automatically sychronizes the circadian rhythms based on a key protein, pk2. The cell strain is supposed to produce a stable and continuous oscillation without the stimulus of any external cause.