Difference between revisions of "Team:TecMonterrey GDL"

 
(57 intermediate revisions by 4 users not shown)
Line 2: Line 2:
 
<html>
 
<html>
  
 +
<head>
 +
  <meta charset="utf-8">
 +
  <title>TecMonterrey_GDL</title>
  
−
<div class="column full_size" >
 
−
<h1> Preliminary project description </h1>
 
−
<p>
 
−
Lactobachill: a smart psychobiotic with anxiolytic and antidepressant properties</p>
 
  
−
<p>The microorganisms that normally reside in the microbiota has been consistently linked to human well-being. Studies show that microbiota not only can impact nutrition and metabolism, but also the mood. Psychobiotics is the field where probiotics and psychotropics (molecules that can alter mood) converge, opening the possibility of therapies where good bacteria can help lighten or reduce the impact of certain psychiatric conditions, such as depression. Depression affects more than 300 million people in the world, shockingly, an increase of more than 18% between 2005 and 2015 was observed according to World Health Organization (2018). There are many barriers towards dealing with depression, from availability of help to non-recognition of the problem. Depression is the leading cause of ill health and disability worldwide. Our Human Practices are centered towards conscientization and against stigmatization of depression; as well as performing a campaign to incentive people to seek aid when they need to.</p>
+
  <!-- mobile responsive meta -->
 +
  <meta name="viewport" content="width=device-width, initial-scale=1">
 +
  <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1">
 +
</head>
  
−
<p>On the other hand, there is a strong relationship between systemic inflammation and psychiatric disorders. Our strategy consists of genetically engineering Lactobacillus rhamnosus GG,  a natural gut probiotic, into producing and possible secreting soluble IL-6 receptors gp80 (mutated for increased affinity) and gp130 in order to aid reducing trans-signalization of the inflammatory pathway of cytokine interleukin 6. Our system will be triggered by nitrosative stress, which is a known pathway of inflammatory, depressive and stress afflictions. Blocking the trans-signaling of IL-6 system also prevents tryptophan catabolism to serotonin to deviate into other catabolites. This is how Lactobachill, can be used as an alternative treatment for depression as well as other inflammatory disorders.
 
−
</p>
 
  
 +
<body>
 +
  <div class="page-wrapper">
 +
    <!-- Preloader -->
 +
    <!-- <div class="preloader"></div> -->
 +
    <!-- Preloader -->
  
  
  
 +
 +
 +
<!--Header Upper-->
 +
 +
 +
<!--Main Header-->
 +
<nav class="navbar navbar-default">
 +
    <a class="navbar-brand">
 +
      <img src="https://static.igem.org/mediawiki/2018/e/e3/T--TecMonterrey_GDL--Home--logo.png" width="80">
 +
    </a>
 +
      <div class="container">
 +
            <!-- Brand and toggle get grouped for better mobile display -->
 +
            <div class="navbar-header">
 +
                  <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#bs-example-navbar-collapse-1"
 +
                        aria-expanded="false">
 +
                        <span class="sr-only">Toggle navigation</span>
 +
                        <span class="icon-bar"></span>
 +
                        <span class="icon-bar"></span>
 +
                        <span class="icon-bar"></span>
 +
                  </button>
 +
            </div>
 +
            <!-- Collect the nav links, forms, and other content for toggling -->
 +
            <div class="collapse navbar-collapse" id="bs-example-navbar-collapse-1">
 +
              <ul class="nav navbar-nav">
 +
                <li class="active"><a href="https://2018.igem.org/Team:TecMonterrey_GDL">Home<span class="sr-only">(current)</span></a></li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Project<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Description">Description</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Abstract">Abstract</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Attributions">Our team</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Partners">Partners</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Checklist">Checklist</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Dry lab<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Parts">Parts</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Composite_Part">Constructs</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Model">Mathematical model</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Wet lab<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/InterLab">Interlab</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Collaborations">Collaborations</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Improve">Improvement</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Human practices<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Human_Practices">Timeline</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href=" https://2018.igem.org/Team:TecMonterrey_GDL/Public_Engagement">Public engagement</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Results<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/GeneticE">Genetic engineering</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Demonstrate">Biomimetric Tri-cultures</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Gut-on-a-chip">Gut on a chip</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Notebook<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Protocols">Protocols</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Lab_Logs">Lab agenda</a></li>
 +
                  </ul>
 +
                </li>
 +
                <li class="dropdown ">
 +
                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">What's next?<span class="caret"></span></a>
 +
                  <ul class="dropdown-menu">
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Entrepreneurship">Business model</a></li>
 +
                    <li role="separator" class="divider"></li>
 +
                    <li><a href="https://2018.igem.org/Team:TecMonterrey_GDL/Legal_Aspect">Legal aspect</a></li>
 +
                  </ul>
 +
                </li>
 +
              </ul>
 +
            </div>
 +
            <!-- /.navbar-collapse -->
 +
      </div>
 +
      <!-- /.container-fluid -->
 +
</nav>
 +
<!--End Main Header -->
 +
 +
<!--=================================
 +
=            Page Slider            =
 +
==================================-->
 +
<!--====  End of Page Slider  ====-->
 +
 +
 +
 +
<!--about section-->
 +
<section class="feature-section ">
 +
  <center>
 +
  <img class="img-responsive" src="https://static.igem.org/mediawiki/2018/b/b5/T--TecMonterrey_GDL--Home--recorridocerebroaintestino.png" alt="service-image">
 +
</center>
 +
</section>
 +
<!--End about section-->
 +
 +
 +
<!--footer-main-->
 +
<footer class="footer-main">
 +
  <div class="footer-top">
 +
  <!--PATROCINADORES-->
 +
  <center>
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/6/67/T--TecMonterrey_GDL--Home--1.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/0/02/T--TecMonterrey_GDL--Home--2.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/c/cc/T--TecMonterrey_GDL--Home--3.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/1/17/T--TecMonterrey_GDL--Home--4.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/d/db/T--TecMonterrey_GDL--Home--5.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/2/2a/T--TecMonterrey_GDL--Home--6.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/9/93/T--TecMonterrey_GDL--Home--7.png" alt="service-image">
 +
    <img class="sponsor-box"  src="https://static.igem.org/mediawiki/2018/7/7b/T--TecMonterrey_GDL--Home--8.png" alt="service-image">
 +
  </center>
 +
  </div>
 +
  <div class="footer-bottom">
 +
  <center>
 +
  <p style="color: #ffffff; text-align:center">TecMonterrey_GDL</p>
 +
  <a href="https://www.facebook.com/pg/IGem-2018-Tec-GDL-1844545129181886/about/?ref=page_internal">
 +
    <img width="25px"
 +
    src="data:image/svg+xml;base64,
 +
  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" />
 +
  </a>
 +
 +
<a href="https://www.instagram.com/igem2018_tecgdl/">
 +
  <img width="25px" src="data:image/svg+xml;base64,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" />
 +
</a>
 +
 +
<a href="https://twitter.com/teamtecgdl?lang=es">
 +
  <img width="25px"
 +
  src="data:image/svg+xml;base64,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" />
 +
 +
</a>
 +
</center>
 +
</div>
 +
 +
</footer>
 +
<!--End footer-main-->
 +
 +
</div>
 +
<!--End pagewrapper-->
 +
</body>
  
 
</html>
 
</html>

Latest revision as of 02:32, 18 October 2018

TecMonterrey_GDL
service-image

TecMonterrey_GDL