Difference between revisions of "Team:USTC"

 
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{{USTC}}
 
 
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<h1> Welcome to iGEM-USTC 2018! </h1>
 
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<p>Our team has been approved and ZHUPI is ready to start the iGEM season! </p>
 
  
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dnszLqtcHYVXQf0wdl0Zdrhp+F4I32sePkqxOccR207Thr3UWEl35nC4aeVuK0OzGfMpGThfaEn4oJI52Xo2F7HYOAfZNJMGTJnv5rfb2eot+Cm0dwW0xc/k5x/avCuYW1qDw14IILDEHwXDVsdRpVHMZUlhPuOMzHAGeIXrhyMdPFaOJ7JUqnxUqLu9oHolxlMc9PPaLw/Y8Nws1KoZPFdPX/D6lM0waZH+zfbyK06/YfFAzTqtd/zB9QVleOtpyz7VFXMvZ+6wyXC8xaeAXMZg6rQe2S7Q8uLYsJ4hdVi+xmYatTadImODwPVbeXdiq9R7HYyi1wpmW0/aQw98XSYX7WvNjMeva4/CplV7i8uhrKUFrXTrL7NOnpe69LBby+QKo8lwzaQOjDUqUgAmmTeOHcrYrfDG4xx8uXlltPtBlpxNAsa4BwIc0m7ZE2I5EEjovEM5o18FimuewgseHEOuI4kcxde/1KZI3PgqTPezlPGMLK4Lxe5sR3Hgq58cy014ufLD+3jmb1w8kiLgGRcG0+KwZRWLne8dwR4L0Vn4VYVohr67QJiHl0efBFP8LMODPtcT4OaPRZ/h06P5UuOq4upj2j3QZJtKx4qqGMu7UTtEb9F3tL8LcELkVnSZ96o9WmG7C4SnGmiLbaiXeqfhqv8AImni+Y4YwC12okXawOIb0J4lVn8DXvFJ3jwX0W3s/RGzGjwUv8Cp/ob5BXnHpT80fN/+D4p2zD81H/RTFuB/yzfovpIZJT/T5AKQydnBpVpjpW5yvm6j2MxYM6F6n2BxVfCs9nUadPK9l6CMraPyhTbl7R+UKbOlZYwtqiqLG8bKtzEl1Oq2blroP0VycPp2aPRVePwz3GQ1w/lgrO4t+PPV28jzyi58xI7iVq5bgjSpy57nB86W7x3zsuw7R5VUaS+mwkGZEGQeMLjsVmRY3S/3YPEQVn4fT1ZzY3vaDCWlxJ8uHcqoZafaahN733UznNOY1fVWWDr6z7qY42M8+XHL3VjlstcCfyx8lRdps71nTMA8RextFuKvK+X1arCynAni3UT8lqUfw2xFTcOjuIWuOOnn/I5fO9OJw+LIJG99zuusyhxLSZHwm33xVy38IKpEtc8O6gEeKyU/wizCf9apgdzvQFMuPbPj5ZjO45Xs7jHe2fJ+Jzrc7rusK980oN5tB35BY8P+DWIaZGNDSbkhhN+MLp+z34dvw5mrin1toBaGgR134lV/Hlta88uOtdrChQcI6LcY13FWdLK9Ii9lmbhI4LWTTltVrWnkpimeSsxhypCieinSNqwUjyUvYnkrMUUexUoVn8On/Dqz9in7EJBoMw8LN7FbYpBS9miGVyishSKJQSCmkgimmiETsoRCIQhsQiEk0NjSjShNCFpUfZhTQoTusRw7eIWCrldJ/wAVNh/ma0/RbiUqTysVh7P4f/d6P/Y1Tp5NSb8NGkP+lqsJRKHlWuzChuzWjuACnoKyyiURaw6SmAVklKUQhdMKSECBRKaSByhHgjwQEppX5IugaSLoQNNRTQZylKkVFEEUIKEChEJoRJQkpJIEiEyEQgjCYCcICAQmhBGEoU0JsQhEKcJQmxGElIhEIFCUKSQQKEQmmgjCE0IEhNEoEhNCBITQgE4QApQiNv/Z">
 
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  <div class="wrapper">
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      <ul class="list-unstyled components">
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          <a href="https://2018.igem.org/Team:USTC">HOME</a>
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          <a href="#projectSubmenu" data-toggle="collapse" aria-expanded="false">PROJECT <i class="fa fa-caret-down"></i></a>
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              <a href="https://2018.igem.org/Team:USTC/Description">Description</a>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Design">Design</a>
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            </li>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Results">Results</a>
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            </li>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Hardware">Hardware</a>
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            </li>
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        <li>
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              <a href="https://2018.igem.org/Team:USTC/Safety">Safety</a>
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            </li>
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    <li>
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              <a href="https://2018.igem.org/Team:USTC/Parts">Parts</a>
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          </ul>
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        </li>
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        <!--Project-->
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              <a href="https://2018.igem.org/Team:USTC/Model">Overview</a>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Model/Single_Cell_Model">Single-cell Model</a>
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            </li>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Model/System_Analysis">System Analysis</a>
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              <a href="https://2018.igem.org/Team:USTC/Model/Performance_evaluation">Performance Evaluation</a>
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              <a href="https://2018.igem.org/Team:USTC/Model/Parameters">Parameters</a>
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          </ul>
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        <!--Model-->
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          <a href="https://2018.igem.org/Team:USTC/InterLab">INTERLAB</a>
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        <!--Interlab-->
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          <a href="https://2018.igem.org/Team:USTC/Notebook">NOTEBOOK</a>
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        <!--Notebook-->
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        <li>
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          <a href="#HPSubmenu" data-toggle="collapse" aria-expanded="false">HUMAN PRACTICES <i class="fa fa-caret-down"></i></a>
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              <a href="https://2018.igem.org/Team:USTC/Human_Practices">Overview</a>
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            </li>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Human_Practices/General_HP">General HP</a>
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            </li>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Human_Practices/Integrated_HP">Integrated HP</a>
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            </li>
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    <li>
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      <a href="https://2018.igem.org/Team:USTC/Collaborations">Collaborations</a>
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          </ul>
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        </li>
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<!--Achievements-->
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<li>
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          <a href="#">ACHIEVEMENTS</a>
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<li>
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          <a href="#Teamsubmenu" data-toggle="collapse" aria-expanded="false">TEAM <i class="fa fa-caret-down"></i></a>
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              <a href="https://2018.igem.org/Team:USTC/Team">Members</a>
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            <li>
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              <a href="https://2018.igem.org/Team:USTC/Attributions">Attributions</a>
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            </li>
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          </ul>
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        </li>
  
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<h3>Before you start</h3>
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<p> Please read the following pages:</p>
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<li> <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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                <h1 id="Abstract" style="margin-bottom: 200px;"> </h1>
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                <h1 class="text-center display-4" >Abstract</h1>
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                            <h2>3-succinoyl-pyridin (SP) is an important precursor of antihypertensive drugs. SP is not
 +
                                easy to obtain and thus makes it expensive. Fortunately, some researchers found a way
 +
                                to transform nicotine to SP.</h2>
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                        </div>
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                            <h2>Nicotine is a highly addictive chemical and its addiction is comparable to well-known
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                                psychological drugs like heroin, cocaine. Uptake of nicotine may promote the abnormal
 +
                                release of neural messengers, which cause emotional and physiological disorders. As a
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                                form of alkaloid, many plants such as Tobacco contain abundant nicotine </h2>
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                            <h2>As a well-known industrial crop, tobacco is widely plant around the world. Mature
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                                tobacco can be used as the raw material for cigarette industry which accounts for an
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                                unsubstitutable portion in China’s economy. </h2>
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                            <img src="https://static.igem.org/mediawiki/2018/7/71/T--USTC--tobacco.gif" width="100%" alt="">
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                            <h2>The tobacco leaves are roasted, cut into lumps, and then sliced and rolled into
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                                cigarettes. In this production process, there will be a large number of waste produced
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                                by tobacco leaves. Some chemicals like nicotine is included in these tobacco waste.</h2>
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                            <h2>This year, our team designed three systems in E.coli K12 to transform nicotine to SP.
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                                The three systems are sensor system, regulation system and degradation system, whose
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                                gene elements are constructed on two plasmid backbones separately.</h2>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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Latest revision as of 03:46, 18 October 2018

Abstract

3-succinoyl-pyridin (SP) is an important precursor of antihypertensive drugs. SP is not easy to obtain and thus makes it expensive. Fortunately, some researchers found a way to transform nicotine to SP.

Nicotine is a highly addictive chemical and its addiction is comparable to well-known psychological drugs like heroin, cocaine. Uptake of nicotine may promote the abnormal release of neural messengers, which cause emotional and physiological disorders. As a form of alkaloid, many plants such as Tobacco contain abundant nicotine

As a well-known industrial crop, tobacco is widely plant around the world. Mature tobacco can be used as the raw material for cigarette industry which accounts for an unsubstitutable portion in China’s economy.

The tobacco leaves are roasted, cut into lumps, and then sliced and rolled into cigarettes. In this production process, there will be a large number of waste produced by tobacco leaves. Some chemicals like nicotine is included in these tobacco waste.

This year, our team designed three systems in E.coli K12 to transform nicotine to SP. The three systems are sensor system, regulation system and degradation system, whose gene elements are constructed on two plasmid backbones separately.