Gap junction proteins are composed of two hemichannels in the plasma membrane of two neighboring cell
They are controlled by the voltage difference between the two cellular interiors,
called transjunctional voltage (Vj)-thus are voltage-gated. They are sites where molecules exchange between adjacent cells.
The voltage sensing mechanism of a hemichannel failed to switch into open state if the other hemichannel was in the inactive state.
CX43, a family member of gap junction proteins,
can only help us to deliver exosome if it is open and exchange signal with neuron cell to trigger membrane fusion process.
Here, we present a model demonstrating a macroscopic situation in gap junctions,
and thereby ensuring the functionality of CX43 as a cytosolic delivery helper.