Difference between revisions of "Team:TU-Eindhoven/Description"

 
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<h1> Project Description </h1>
 
<h1> Project Description </h1>
 
<p>Living cells can continuously monitor their microenvironment and respond to local environmental changes by expressing specific gene sets. This makes living cells attractive to use in small devices and smart materials. Bacterial cells are particularly attractive since they can be genetically "tailored" to produce many different types of proteins in response to almost any known type of chemical, physical or biological stress.</p>
 
<p>Living cells can continuously monitor their microenvironment and respond to local environmental changes by expressing specific gene sets. This makes living cells attractive to use in small devices and smart materials. Bacterial cells are particularly attractive since they can be genetically "tailored" to produce many different types of proteins in response to almost any known type of chemical, physical or biological stress.</p>
 
<p>Unfortunately, exploiting this potential is held back by challenges like maintaining the viability, functionality and safety of the living components in freestanding materials and devices. The bacteria can be contained in a gel, but if they leak out and escape into the environment they may cause major problems.</p>
 
<p>Unfortunately, exploiting this potential is held back by challenges like maintaining the viability, functionality and safety of the living components in freestanding materials and devices. The bacteria can be contained in a gel, but if they leak out and escape into the environment they may cause major problems.</p>
 
<p>We aim to design a living material in which the bacteria are immobilized within the hydrogel by using an adhesive protein which originates from an Antarctic bacteria. In this way, we’ll create a living material that can safely be used outside of the laboratory environment.</p>
 
<p>We aim to design a living material in which the bacteria are immobilized within the hydrogel by using an adhesive protein which originates from an Antarctic bacteria. In this way, we’ll create a living material that can safely be used outside of the laboratory environment.</p>
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<p padding-bottom: 3cm;>We aim to apply our living material to wound healing. Wounds are prone to infections of pathogenic bacteria, which dramatically slow down wound healing and are increasingly becoming resistant to antibiotics. Bandages may prevent infections to some extent, but they would be much more effective if they continuously release proteins that fight pathogens. This is what the bacteria in our material will do. They will produce a small protein named lysostaphin. This is an enzyme that specifically destroys staphylococcus aureus and other staphylocci, which are currently the most common cause of infections in hospitalized patients. In this way, a wound healing hydrogel can be created. This hydrogel can be easily and safely applied as a patch on the skin. This way, our living material will form a convenient alternative to antibiotics.</p>
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<p>We aim to apply our living material to wound healing. Wounds are prone to infections of pathogenic bacteria, which dramatically slow down wound healing and are increasingly becoming resistant to antibiotics. Bandages may prevent infections to some extent, but they would be much more effective if they continuously release proteins that fight pathogens. This is what the bacteria in our material will do. They will produce a small protein named lysostaphin. This is an enzyme that specifically destroys staphylococcus aureus and other staphylocci, which are currently the most common cause of infections in hospitalized patients. In this way, a wound healing hydrogel can be created. This hydrogel can be easily and safely applied as a patch on the skin. This way, our living material will form a convenient alternative to antibiotics.</p>
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<h1>Description</h1>
 
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
 
  
 
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<h3>What should this page contain?</h3>
 
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<li> A clear and concise description of your project.</li>
 
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
 
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<h3>Inspiration</h3>
 
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<p>See how other teams have described and presented their projects: </p>
 
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
 
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
 
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
 
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
 
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<h3>Advice on writing your Project Description</h3>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.
 
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<h3>References</h3>
 
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
 
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Latest revision as of 21:36, 2 October 2018

Project Description

Living cells can continuously monitor their microenvironment and respond to local environmental changes by expressing specific gene sets. This makes living cells attractive to use in small devices and smart materials. Bacterial cells are particularly attractive since they can be genetically "tailored" to produce many different types of proteins in response to almost any known type of chemical, physical or biological stress.

Unfortunately, exploiting this potential is held back by challenges like maintaining the viability, functionality and safety of the living components in freestanding materials and devices. The bacteria can be contained in a gel, but if they leak out and escape into the environment they may cause major problems.

We aim to design a living material in which the bacteria are immobilized within the hydrogel by using an adhesive protein which originates from an Antarctic bacteria. In this way, we’ll create a living material that can safely be used outside of the laboratory environment.

We aim to apply our living material to wound healing. Wounds are prone to infections of pathogenic bacteria, which dramatically slow down wound healing and are increasingly becoming resistant to antibiotics. Bandages may prevent infections to some extent, but they would be much more effective if they continuously release proteins that fight pathogens. This is what the bacteria in our material will do. They will produce a small protein named lysostaphin. This is an enzyme that specifically destroys staphylococcus aureus and other staphylocci, which are currently the most common cause of infections in hospitalized patients. In this way, a wound healing hydrogel can be created. This hydrogel can be easily and safely applied as a patch on the skin. This way, our living material will form a convenient alternative to antibiotics.