Difference between revisions of "Team:NYMU-Taipei/Applied Design"
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<p>We decided to design this product because we noticed that current animal and cell models have many flaws that cannot be ignored.</p> | <p>We decided to design this product because we noticed that current animal and cell models have many flaws that cannot be ignored.</p> | ||
<h3>Animal model</h3> | <h3>Animal model</h3> | ||
| − | <p>Mice are the most commonly used animal model | + | <p>Mice are the most commonly used animal model for the research on AGA. Researchers traditionally test the curing properties of their drug candidates on shaved mice, and observe the regrowth rate. However, this process is very different from hair loss caused by AGA, and since mice do not have human androgen receptors, it is unreasonable to use mice as the model to perform AGA drug screening.</p> |
<p>Some alternative choices include using Primates and transgenic mice or transplanting human hair tissue into immunodeficient mouse. But, these methods are too expensive and not suitable for large scale drug screening.</p> | <p>Some alternative choices include using Primates and transgenic mice or transplanting human hair tissue into immunodeficient mouse. But, these methods are too expensive and not suitable for large scale drug screening.</p> | ||
<p>Last but not least, animal testing has become a controversial issue nowadays because such experiments are a violation of animal rights, and scientists follow “the three Rs principles”: Reduction, Refinement, and Replacement.</p> | <p>Last but not least, animal testing has become a controversial issue nowadays because such experiments are a violation of animal rights, and scientists follow “the three Rs principles”: Reduction, Refinement, and Replacement.</p> | ||
Revision as of 16:21, 17 October 2018
How well does the product address the problem versus other potential solutions?
Our project, Hair to Stay, aims to establish an easier and better drug screening system for Androgenetic Alopecia (AGA) using both in-vitro and cell-based methods.
We decided to design this product because we noticed that current animal and cell models have many flaws that cannot be ignored.
Animal model
Mice are the most commonly used animal model for the research on AGA. Researchers traditionally test the curing properties of their drug candidates on shaved mice, and observe the regrowth rate. However, this process is very different from hair loss caused by AGA, and since mice do not have human androgen receptors, it is unreasonable to use mice as the model to perform AGA drug screening.
Some alternative choices include using Primates and transgenic mice or transplanting human hair tissue into immunodeficient mouse. But, these methods are too expensive and not suitable for large scale drug screening.
Last but not least, animal testing has become a controversial issue nowadays because such experiments are a violation of animal rights, and scientists follow “the three Rs principles”: Reduction, Refinement, and Replacement.
Tissue culture model
Currently used tissue culture models are usually samples from patients and could only be obtained from research hospitals. Therefore, they are not easily available and are not capable for large scale drug screening.
To solve this real-world problem, we came up with our product design with careful scientific consideration and worked to prove that our screening system really works.
How does the hair cycle broadly impact our lives and environment in positive and negative ways ?
Demonstration of our products
We made a video with 3D models to demonstrate our products and how they work.
Evaluation
To evaluate the possible impact and value of our project, we conducted several analyses and meetings, which could be found in our human practices, entrepreneurship, and safety pages.
Human Practices
Several inspiring examples include visiting experts, patient interviews, drug screening company, and a pharmaceutical corporation. Through our meeting with experts, potential users, and stakeholders on this hair loss issue, we can claim that our product, an easier and better drug screening system, may provide significant help with future drug screening and contribute to the discovery of better pharmaceutical products against Androgenetic Alopecia.
Entrepreneurship
In our entrepreneurship page, we conducted extensive analysis (SWOT, customer behavior and cost-benefit analysis) to estimate the difficulties, advantages, and potential of our products. These analyses help us understand how our products can impact people’s lives.
Safety
Although our products are for laboratory use only and do not contain toxins or drug resistance genes, we strictly followed several regulations to avoid any possible risk. We ensured the implementation of all of these methods to prevent accidents, contamination, and the potential spread of pathogens.
References:
- Sundberg, J. P., Beamer, W. G., Uno, H., Neste, D. V., & King, L. E. (2002, May 25). Androgenetic Alopecia: In Vivo Models.
- Randall, V. A., Sundberg, J. P., & Philpott, M. P. (2015, December 16). Animal and in vitro Models for the Study of Hair Follicles.
- The 3Rs and Animal Wefare | Understanding Animal Research. (n.d.).