Team:BioMarvel/Description

≡

• PROJECT▾
  • Description
  • Demonstrate
  • Parts
  • Application

• LAB▾　　
  • Experiments
    & Results
  • InterLab
  • Safety

• HUMAN PRACTICES▾
  • Public Engagement
  • Integrated Practices

• NOTEBOOK▾
  • Lab Journal
  • References

• PEOPLE▾
  • Team
  • Attribution
  • Collaboration

• ACHIEVEMENT

• ENTREPRENEURSHIP

Description

This study is about the synthesis process and the creation of recombinant vectors of GBP-ProG fusion proteins to be used in biosensor for heart failure diagnosis. In this experiment, we created a genetically modified recombinant vectors that contains genes which code gold binding protein and protein G. Through this research, not only all types of antibodies simply secure themselves to the chip surface, but also give adequate orientation of the fixed antibody. The results suggest a simple method of immobilizing antibodies to the gold surface without any chemical treatment. This study will help develop a fusion protein with a much more efficient function, reducing expensive antibody consumption and increasing biosensor sensitivity.

Reference

1. McMurray JJ, Pfeffer MA (2005). "Heart failure". Lancet. 365 (9474): 1877–89.
2. GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 388 (10053): 1545–1602.
3. 3. Dickstein K, Cohen-Solal A, Filippatos G, et al. (2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur. Heart J. 29 (19): 2388–442
4. 4. Park TJ, Ko S et al. (2006). Protein Nanopatterns and Biosensors Using Gold Binding Polypeptide as a Fusion Partner. Anal.Chem. 78:7197-205

Inspiration

See how other teams have described and presented their projects:

• 2016 Imperial College
• 2016 Wageningen UR
• 2014 UC Davis
• 2014 SYSU Software

Advice on writing your Project Description

We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.

References

iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.