Difference between revisions of "Team:Montpellier"

 
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<h3>Why is it crucial to find a new approach to contraception?</h3>
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Hormonal contraception has a lot of side effects for women (such as weight gain or acne), a pill is easy to forget, and there is an environmental impact since water can be contaminated by hormones. </br>
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Despite the huge progress made for contraception since the beginning of the 20th century contraception still needs improvment.<br/>
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We want to use microbicide with a spermicidal effect as a new way of contraception: safe and affordable, with a long term effect.
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<h3> How do we do that ? </h3>
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We decided to focus on making a new kind of contraceptive using <i>Lactobacillus jensenii</i>, which is one of the most represented bacteria in the vaginal flora. This hormone-free contraception uses a designed Lactobacillus jensenii that has the ability to immobilize spermatozoa in the vagina. <br/>
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How does it really work? Our goal is to create bacteria capable of having a “switch effect”. When a woman decides to turn it on, bacteria will have a spermicidal effect and will allow in situ contraception. Otherwise, bacteria will be in “off mode”, and spermatozoa will be able to pass. <br/>
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Several studies have demonstrated that many molecules have spermicidal activity, we are focusing on :
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<caption>Spermicidal molecules</caption>
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      <th>Name</th>
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      <th>Type of molecule</th>
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      <th>Origin</th>
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      <td>Nisin</td>
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      <td>Lantipeptid</td>
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      <td>Lactococcus lactis</td>
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      <td>Lacticin 3147</td>
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      <td>Lantipeptid</td>
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      <td>Lactococcus lactis</td>
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      <td>Subtilosin A</td>
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      <td>Sactipeptid</td>
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      <td>Bacillus subtilis</td>
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      <td>Magainin II</td>
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      <td>Magainin</td>
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      <td>Xenopus laevis</td>
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      <td>LL37</td>
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      <td>Cathelicidin antimicrobial peptid</td>
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      <td>Homo sapiens</td>
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      <td>YLP20</td>
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      <td>Anti bodies</td>
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      <td>Homo sapiens</td>
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      <td>AS16</td>
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      <td>Anti bodies</td>
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      <td>Homo sapiens</td>
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</table>
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The idea is to introduce the genes that are coding for the spermicidal peptids and anti bodies into Lactobacillus jensenii and then to apply a colony of these designed bacteria into the vagina for long-term contraception.
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Latest revision as of 20:00, 17 October 2018

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