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| | + | <title>home</title> |
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| | + | <img class="banniere" src="https://static.igem.org/mediawiki/2018/c/cf/T--Montpellier--banniere-mtp-home.png"/> |
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| − | <img src="https://static.igem.org/mediawiki/2018/a/af/T--Montpellier--baniere_wiki_vagineering.png"> | + | <p class = "spz"><img class="accueil" src = "https://static.igem.org/mediawiki/2018/ 2/ 25/T--Montpellier-- page_acceuil_nouveau_3.png" > </p> |
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| | + | <area shape="circle" coords="530,240,80" href="https://2018.igem.org/Team:Montpellier/Public_Engagement"/> |
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| − | </div> | + | <section> |
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| | + | <center><video class="image_figure" controls> |
| | + | <source src="https://static.igem.org/mediawiki/2018/8/8b/T--Montpellier--video_vagineering_mtp.mp4" type="video/mp4"> |
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| − | <div class="column full_size" > | + | </section> |
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| − | <h3>Why is it crucial to find a new approach to contraception?</h3>
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| − | Hormonal contraception has a lot of side effects for women (such as weight gain or acne), a pill is easy to forget, and there is an environmental impact since water can be contaminated by hormones. </br>
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| − | Despite the huge progress made for contraception since the beginning of the 20th century contraception still needs improvment.<br/>
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| − | We want to use microbicide with a spermicidal effect as a new way of contraception: safe and affordable, with a long term effect.
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| − | <h3> How do we do that ? </h3>
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| − | <p>
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| − | We decided to focus on making a new kind of contraceptive using <i>Lactobacillus jensenii</i>, which is one of the most represented bacteria in the vaginal flora. This hormone-free contraception uses a designed Lactobacillus jensenii that has the ability to immobilize spermatozoa in the vagina. <br/>
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| − | How does it really work? Our goal is to create bacteria capable of having a “switch effect”. When a woman decides to turn it on, bacteria will have a spermicidal effect and will allow in situ contraception. Otherwise, bacteria will be in “off mode”, and spermatozoa will be able to pass. <br/>
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| − | Several studies have demonstrated that many molecules have spermicidal activity, we are focusing on some of them such as Nisin, Subtilosin.. (for more information : <a href = "https://2018.igem.org/Team:Montpellier/Description"> Description of the projet</a>)
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| − | The idea is to introduce the genes that are coding for the spermicidal peptids and anti bodies into Lactobacillus jensenii and then to apply a colony of these designed bacteria into the vagina for long-term contraception.
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| − | <h3> <i>Lactobacillus jensenii</i> a little-known bacteria from scientific consortia </h3>
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| − | <p>
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| − | <i>Lactobacillus jensenii</i> is a bacteria little studied. We can find it in the vagina (23% of vaginal microflora),on the skins of grapes at the time of their harvest. Moreover, in the industry <i>L. jensenii</i> is sometimes used in producing fermented foods. </br> </br>
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| − | A part of our project is to establish a toolbox of <i>L. jensenii</i> thanks to bioinformatic tools and modelisation. Indeed <i>L.jensenii</i> is essential for the vagina health.
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| − | We hope that a better knowledge of this bacteriua essential to the proper functioning of the female genital tract will help a better understanding of certain diseases such as fungal infections, urinary tract infections..
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| − | </p>
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| − | <img src="https://static.igem.org/mediawiki/2018/1/16/T--Montpellier--Logo_UM.png" style="width:100px;height:100px;" href="https://www.umontpellier.fr/">
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