|
|
| (117 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| | {{Montpellier}} | | {{Montpellier}} |
| − |
| |
| | | | |
| | <html> | | <html> |
| − | <div class="column full_size" > | + | <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.1.0/css/all.css" integrity="sha384-lKuwvrZot6UHsBSfcMvOkWwlCMgc0TaWr+30HWe3a4ltaBwTZhyTEggF5tJv8tbt" crossorigin="anonymous"> |
| − | <img src="https://static.igem.org/mediawiki/2018/a/af/T--Montpellier--baniere_wiki_vagineering.png"/>
| + | <head> |
| − | </div> | + | <meta charset="utf-8" /> |
| | + | <link rel="stylesheet" href="style.css" /> |
| | + | <title>home</title> |
| | + | <script |
| | + | src="https://code.jquery.com/jquery-3.3.1.min.js" |
| | + | integrity="sha256-FgpCb/KJQlLNfOu91ta32o/NMZxltwRo8QtmkMRdAu8=" |
| | + | crossorigin="anonymous"></script> |
| | | | |
| | + | <style> |
| | + | .spz { |
| | + | text-align: center; |
| | + | display:flex; |
| | + | flex-direction: column; |
| | + | align-items: center |
| | + | } |
| | + | .accueil { |
| | + | width: 55%; |
| | + | } |
| | | | |
| − | <div class="column full_size" >
| + | path:hover{ |
| | + | cursor:pointer; |
| | + | fill:505050; |
| | + | } |
| | | | |
| − | <h3>Why is it crucial to find a new approach to contraception?</h3>
| + | </style> |
| − | <p>
| + | |
| | | | |
| − | Hormonal contraception has a lot of side effects for women (such as weight gain or acne), a pill is easy to forget, and there is an environmental impact since water can be contaminated by hormones. Moreover, some women cannot take pills because of
| + | </head> |
| − | cardiovascular problems and family history.
| + | |
| − | </br> | + | |
| − | </br>
| + | |
| − | Despite the huge progress made for contraception since the beginning of the 20th century, contraception still needs improvment.
| + | |
| − | </br>
| + | |
| − | </br>
| + | |
| − | We want to use microbicide with a spermicidal effect as a new way of contraception: safe and affordable, with a long term effect.
| + | |
| − | </br>
| + | |
| − | </br>
| + | |
| | | | |
| − | </p> | + | <body> |
| | | | |
| − | <h3> How do we do that ? </h3> | + | <img class="banniere" src="https://static.igem.org/mediawiki/2018/c/cf/T--Montpellier--banniere-mtp-home.png"/> |
| − | <p>
| + | |
| − | We decided to focus on making a new kind of contraceptive using <i>Lactobacillus jensenii</i>, which is one of the most represented bacteria in the vaginal flora. This hormone-free contraception uses a designed <I>L. jensenii</i> that has the ability to immobilize spermatozoa in the vagina.
| + | |
| − | <br/>
| + | |
| − | </br>
| + | |
| − | How does it really work? Our goal is to create bacteria capable of having a “switch effect”: when a woman decides to turn it on, bacteria will have a spermicidal effect and will allow in situ contraception. Otherwise, bacteria will be in “off mode”, and spermatozoa will be able to pass. <br/>
| + | |
| | | | |
| − | Several studies have demonstrated that many molecules have spermicidal activity, we are focusing on some of them such as Nisin, Subtilosin... (for more information : <a href = "https://2018.igem.org/Team:Montpellier/Description"> Description of the projet</a>)
| + | <p class = "spz"><img class="accueil" src = "https://static.igem.org/mediawiki/2018/2/25/T--Montpellier--page_acceuil_nouveau_3.png"> </p> |
| | + | <map name="spz2"> |
| | + | <area shape="circle" coords="210,240,80" href="lien1"/> |
| | + | <area shape="circle" coords="380,240,80" href="lien2" /> |
| | + | <area shape="circle" coords="530,240,80" href="https://2018.igem.org/Team:Montpellier/Public_Engagement"/> |
| | + | </map> |
| | | | |
| − | The idea is to introduce the genes that are coding for the spermicidal peptids and anti bodies into Lactobacillus jensenii and then to apply a colony of these designed bacteria into the vagina for long-term contraception.
| + | <section> |
| − | </br> | + | |
| − | </br>
| + | |
| − | </p>
| + | |
| | | | |
| | + | <center><video class="image_figure" controls> |
| | + | <source src="https://static.igem.org/mediawiki/2018/8/8b/T--Montpellier--video_vagineering_mtp.mp4" type="video/mp4"> |
| | + | </video></center> |
| | | | |
| − | <h3> <i>Lactobacillus jensenii</I> : a little-known bacteria </h3>
| + | </section> |
| − | <p>
| + | |
| − | <i>Lactobacillus jensenii</i> is a little studied bacteria. We can find it in the vagina (23% of vaginal microflora),on the skins of grapes at the time of their harvest. Moreover, in the industry <i>L. jensenii</i> is sometimes used in producing fermented foods. </br> </br>
| + | |
| − | A part of our project is to establish a toolbox of <i>L. jensenii</i> by integrating experiments, bioinformatic tools and modelisation. Indeed <i>L.jensenii</i> is essential for the vagina health.
| + | |
| − | We hope that a better knowledge of this bacterium, essential to the proper functioning of the female genital tract, will help a better understanding of certain diseases such as fungal and urinary tract infections.
| + | |
| − | </p>
| + | |
| | | | |
| − | <img src="https://static.igem.org/mediawiki/2018/c/c7/T--Montpellier--logo_sponsors_2.png"> | + | </body> |
| | + | </html> |
| | | | |
| − | <!--
| + | {{Template:Montpellier/Footer}} |
| − | <a href="http://www.cbs.cnrs.fr/index.php/fr/">
| + | |
| − | <img src="https://static.igem.org/mediawiki/2018/d/d7/T--Montpellier--Logo_CBS.png" style="width:114px;height:100px;"/>
| + | |
| − | </a>
| + | |
| − | | + | |
| − | <a href="https://www.umontpellier.fr/">
| + | |
| − | <img src="https://static.igem.org/mediawiki/2018/1/16/T--Montpellier--Logo_UM.png" style="width:100px;height:100px;"/>
| + | |
| − | </a>
| + | |
| − | | + | |
| − | <a href="http://reseau-figure.fr/">
| + | |
| − | <img src="https://static.igem.org/mediawiki/2018/3/32/T--Montpellier--Logo_r%C3%A9seaufigure.png" style="width:402px;height:100px;"/>
| + | |
| − | </a>
| + | |
| − | | + | |
| − | <a href="http://muse.edu.umontpellier.fr/">
| + | |
| − | <img src="https://static.igem.org/mediawiki/2018/3/3e/T--Montpellier--Logo_MUSE.png" style="width:200px;height:100px;"/>
| + | |
| − | </a>
| + | |
| − | | + | |
| − | <a href="https://www.france-science.org/-Accueil-Francais-.html">
| + | |
| − | <img src="https://static.igem.org/mediawiki/2018/6/63/T--Pasteur_Paris--Logo-AmbassadeUSA.jpg" style="width:97px;height:100px;"/>
| + | |
| − | </a>
| + | |
| − | -->
| + | |
| − | | + | |
| − | </div>
| + | |
| − | | + | |
| − | | + | |
| − | | + | |
| − | </html>
| + | |
