Team:Montpellier/Description

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Description Antisperm antibodies Peptides Lactobacillus jensenii Conclusions Perspectives

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Description

The different parts of the Vagineering project

To achieve our goal, we want to design a L. jensenii with a spermicidal effect which can allow a long term contraception for women. We are focusing on different types of spermidical molecules :

Spermicidal molecules

Name	Type of molecule	Origin
Nisin	Lantipeptid	Lactococcus lactis
Lacticin 3147	Lantipeptid	Lactococcus lactis
Subtilosin A	Sactipeptid	Bacillus subtilis
Magainin II	Magainin	Xenopus laevis
LL37	Cathelicidin antimicrobial peptid	Homo sapiens
YLP20	Antibody	Homo sapiens
AS16	Antibody	Homo sapiens

The chassis

We are going to use two bacteria : Bacillus subtilis and Lactobacillus jensenii, two gram positive bacteria. We choosed B. subtilis because it's a model bacteria for the gram positive. Indeed the final goal is to modify L. jensenii.