Team:Lambert GA/CALM DISCUSSION

CALM ELECTROPEN
BACKGROUND DATA & METHODS RESULTS DISCUSSION COLOR Q SUPPLEMENTARY REFERENCES
COLOR Q CHROME Q REFERENCES
PRINCIPLES & DESIGN MODEL & THEORY PRODUCT DESIGN REFERENCES
INTEGRATED HUMAN PRACTICES EDUCATION & ENGAGEMENT COLLABORATIONS
BASIC PARTS COMPOSITE PARTS
DESCRIPTION BACKGROUND DESIGN EXPERIMENTS LAB NOTEBOOK INTERLAB RESULTS DEMONSTRATE THE VISION
TEAM MEMBERS ATTRIBUTIONS

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Summary


Cholera has killed millions of people, and without proper action, could continue to do so for many years. Many have modeled and analyzed cholera outbreaks globally to predict where they will next strike, or to forecast cholera cases and/or risk during one particular outbreak. Lambert iGEM has itself created a system of models, CALM, the Cholera Artificial Learning Model, to forecast exact cholera incidence, with the proof-of-concept forecasting cases in Yemen. Consisting of four XGBoost models working in conjunction, CALM is able to make predictions that are highly accurate and reliable, utilizing features, machine learning techniques, and predictor for variables that other machine learning models either do not do or do not do enough of. In addition, by using a system of four models, CALM is not only able to provide a comprehensive 2 month report with 2-week intervals, but also ensures that none of its models “fall behind” by making a prediction too early or too late. Sudden spikes in the cholera prediction may not be modeled accurately by models of later time frames, but more immediate aspects of the model, such as the predictor for 0-2 weeks, can effectively account for sudden changes in the cholera cases. but As demonstrated in figures 1, 2, and 3, CALM has been shown, at least within the data used for this year’s iGEM project, to be a reliable, powerful way to reduce the number of people suffering from cholera by providing a means for cholera to be predicted so that medical supplies can be distributed to pre-empt an outbreak.


CALMWatch- an SMS bot


Lambert iGEM has also developed an SMS bot utilizing the Twilio API and the Flask web framework for gathering health and sanitation data from areas affected by a cholera outbreak by directly talking to those that are affected, providing a highly detailed and specific dataset, as data is being directly gathered from the people. This bot, named CALMWatch, allows for a healthcare organization or government agency to distribute an SMS survey to a given population so that affected people can report data related to an ongoing cholera outbreak such as cleanliness of water sources, water storage, and waste management. This data can then be fed into the CALM model in real time to increase the accuracy of the model and increase the size of its databases. This bot is based on RatWatch, an open-source SMS-based rat reporting service for the Atlanta area developed by M. Koohang (Zegura & DiSalvo 2018), who graciously allowed Lambert iGEM to modify it for the purposes of the 2018 project.

Further Development


While the efficacy of the model has only been proven in Yemen, it is expected that with further development and adaptation CALM will be used to predict outbreaks around the world. As development on the project progresses, Lambert iGEM hopes to construct a fully autonomous web-based software platform comprising of data collection bots that collect data from major health and sanitation sources, software that is capable of syncing data from the ColorQ app and from CALMWatch surveys with CALM’s databases, and software that coordinates global usage of the model so that users can share and distribute results and model improvements more easily. In terms of CALM itself, Lambert iGEM also hopes to engineer more features for the model by acquiring data for more environmental factors, possibly including algal blooms, migration data, and OCV campaign data.