Team:Montpellier/Demonstrate

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Description Antisperm antibodies Peptides Lactobacillus jensenii Conclusions Perspectives

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Protocols Toolbox Antisperm Antibodies Peptides Sperm Motility Assay InterLab

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Demonstrate

Gold Medal Criterion #4

Teams that can show their system working under real world conditions are usually good at impressing the judges in iGEM. To achieve gold medal criterion #4, convince the judges that your project works. There are many ways in which your project working could be demonstrated, so there is more than one way to meet this requirement. This gold medal criterion was introduced in 2016, so check our what 2016 teams did to achieve their gold medals!

Please see the 2018 Medals Page for more information.

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Proof of concept : analyse of spermtozoa motility

Introduction

Antimicrobial peptides (AMPs) have a great affinity for spermatozoa membranes. They are composed of anionic phospholipids such as phosphatidylglycerol and phosphatidylserine in the plasma membrane. Therefore AMP have to ability to inhibit motility of spermatozoa and prevent the fertilization. Antisperm antibodies are antibodies that can fix on specific parts of spermatozoa (YLP12 antigen) and inhibit their motility. The exact mechanism for this motility inhibition is not known yet. We quantified the action of the AMPs and antibodies on the motility of spermatozoa. This is our proof of concept to test the anticonceptional efficiency of the molecules produced by our bacteria.